Effect of divalent metals on the neuronal proteasomal system, prion protein ubiquitination and aggregation

► Mouse neuronal cells are more sensitive to cadmium induced neurotoxicity than Mn. ► Cadmium but not Mn inhibits proteasomal activity. ► Cadmium induces accumulation of high molecular weight ubiquitinated proteins. ► Cadmium induces formation of soluble oligomers but not PK resistant prion protein....

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Veröffentlicht in:	Toxicology letters 2012-11, Vol.214 (3), p.288-295
Hauptverfasser:	Kanthasamy, A.G., Choi, C., Jin, H., Harischandra, D.S., Anantharam, V., Kanthasamy, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cadmium Chloride - toxicity Cell Survival - drug effects Cells, Cultured Chemical and industrial products toxicology. Toxic occupational diseases Chlorides - adverse effects Manganese Manganese Compounds - adverse effects Medical sciences Metals Metals and various inorganic compounds Mice Neurons - drug effects Neurons - metabolism Neurotoxicity Prions - chemistry Prions - drug effects Prions - metabolism Proteasome dysfunction Proteasome Endopeptidase Complex - drug effects Proteasome Endopeptidase Complex - metabolism Protein aggregation Protein Multimerization - drug effects Toxicology Ubiquitination - drug effects
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