CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo

The role of CD31, an Ig-like molecule expressed by leukocytes and endothelial cells (ECs), in the regulation of T lymphocyte trafficking remains contentious. Using CD31-deficient mice, we show that CD31 regulates both constitutive and inflammation-induced T cell migration in vivo. Specifically, T ce...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-10, Vol.189 (8), p.4104-4111
Hauptverfasser:	Ma, Liang, Cheung, Kenneth C P, Kishore, Madhav, Nourshargh, Sussan, Mauro, Claudio, Marelli-Berg, Federica M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Communication - immunology Cells, Cultured Endothelium, Vascular - cytology Endothelium, Vascular - immunology Endothelium, Vascular - metabolism Female Inflammation Lymphoid Tissue - cytology Lymphoid Tissue - immunology Male Mice Organ Culture Techniques Platelet Endothelial Cell Adhesion Molecule-1 - administration & dosage Platelet Endothelial Cell Adhesion Molecule-1 - genetics Platelet Endothelial Cell Adhesion Molecule-1 - physiology T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism Transendothelial and Transepithelial Migration - genetics Transendothelial and Transepithelial Migration - immunology
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