Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo

Activation of focal adhesion kinase (FAK) is hypothesized to play an important role in the pathogenesis of human breast cancer. To directly evaluate the role of FAK in mammary tumour progression, we have used a conditional FAK mouse model and mouse mammary tumour virus (MMTV)-driven Cre recombinase...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Breast cancer research : BCR 2012-02, Vol.14 (1), p.R36-R36, Article R36
Hauptverfasser:	Lahlou, Hicham, Sanguin-Gendreau, Virginie, Frame, Margaret C, Muller, William J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Apoptosis Breast cancer Cancer metastasis Cell Movement Cell Proliferation Cell Transformation, Neoplastic - metabolism Crk-Associated Substrate Protein - metabolism Development and progression Female Focal Adhesion Kinase 1 - deficiency Focal Adhesion Kinase 1 - genetics Focal Adhesion Kinase 1 - physiology Focal Adhesion Kinase 2 - metabolism Gene Deletion Genetic engineering Integrases - metabolism Lung Neoplasms - enzymology Lung Neoplasms - metabolism Lung Neoplasms - secondary Mammary Neoplasms, Experimental - enzymology Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Mice Mice, Transgenic Neoplasm Transplantation Paxillin - metabolism Phosphorylation Receptor, ErbB-2 - metabolism Tumor Burden
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!