Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer

Overexpression of the oxygen-responsive transcription factor hypoxia-inducible factor 1α (HIF-1α) correlates with poor prognosis in breast cancer patients. The mouse mammary tumor virus polyoma virus middle T (MMTV-PyMT) mouse is a widely utilized preclinical mouse model that resembles human luminal...

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Veröffentlicht in:	Breast cancer research : BCR 2012-01, Vol.14 (1), p.R6-R6, Article R6
Hauptverfasser:	Schwab, Luciana P, Peacock, Danielle L, Majumdar, Debeshi, Ingels, Jesse F, Jensen, Laura C, Smith, Keisha D, Cushing, Richard C, Seagroves, Tiffany N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caspase 3 - metabolism Cell Proliferation Cell Separation Epidermal Growth Factor - physiology Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial Cells - physiology Estrogen Receptor alpha - metabolism Female Flow Cytometry Gene Expression Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - physiology Ki-67 Antigen - metabolism Lung Neoplasms - metabolism Lung Neoplasms - secondary Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Neoplasm Invasiveness Neoplasm Transplantation Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Phosphoproteins - metabolism Spheroids, Cellular - metabolism Trans-Activators - metabolism Tumor Burden Tumor Cells, Cultured
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