γδ T Cells Recognize a Microbial Encoded B Cell Antigen to Initiate a Rapid Antigen-Specific Interleukin-17 Response
γδ T cells contribute uniquely to immune competence. Nevertheless, how they function remains an enigma. It is unclear what most γδ T cells recognize, what is required for them to mount an immune response, and how the γδ T cell response is integrated into host immune defense. Here, we report that a n...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2012-09, Vol.37 (3), p.524-534 |
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| creator | Zeng, Xun Wei, Yu-Ling Huang, Jun Newell, Evan W. Yu, Hongxiang Kidd, Brian A. Kuhns, Michael S. Waters, Ray W. Davis, Mark M. Weaver, Casey T. Chien, Yueh-hsiu |
| description | γδ T cells contribute uniquely to immune competence. Nevertheless, how they function remains an enigma. It is unclear what most γδ T cells recognize, what is required for them to mount an immune response, and how the γδ T cell response is integrated into host immune defense. Here, we report that a noted B cell antigen, the algae protein phycoerythrin (PE), is a murine and human γδ T cell antigen. Employing this specificity, we demonstrated that antigen recognition activated naive γδ T cells to make interleukin-17 and respond to cytokine signals that perpetuate the response. High frequencies of antigen-specific γδ T cells in naive animals and their ability to mount effector response without extensive clonal expansion allow γδ T cells to initiate a swift, substantial response. These results underscore the adaptability of lymphocyte antigen receptors and suggest an antigen-driven rapid response in protective immunity prior to the maturation of classical adaptive immunity.
► Murine and human γδ T cells recognize a microbial encoded B cell antigen ► Naive γδ T cells develop into IL-17 effectors in response to this antigen ► Antigen-activated γδ T cells gain the ability to respond to cytokine signals ► Robust and sustained IL-17 production requires both TCR and cytokine signals |
| doi_str_mv | 10.1016/j.immuni.2012.06.011 |
| format | Article |
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► Murine and human γδ T cells recognize a microbial encoded B cell antigen ► Naive γδ T cells develop into IL-17 effectors in response to this antigen ► Antigen-activated γδ T cells gain the ability to respond to cytokine signals ► Robust and sustained IL-17 production requires both TCR and cytokine signals</description><identifier>ISSN: 1074-7613</identifier><identifier>EISSN: 1097-4180</identifier><identifier>DOI: 10.1016/j.immuni.2012.06.011</identifier><identifier>PMID: 22960222</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Algal Proteins - immunology ; Algal Proteins - metabolism ; Amino Acid Sequence ; Animals ; Antigens - immunology ; Antigens - metabolism ; B-Lymphocytes - immunology ; B-Lymphocytes - metabolism ; Base Sequence ; Binding Sites - genetics ; Cells, Cultured ; Female ; Flow Cytometry ; Humans ; Interleukin-17 - genetics ; Interleukin-17 - immunology ; Interleukin-17 - metabolism ; Kinetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, Transgenic ; Phycoerythrin - immunology ; Phycoerythrin - metabolism ; Protein Binding - immunology ; Receptors, Antigen, T-Cell, gamma-delta - genetics ; Receptors, Antigen, T-Cell, gamma-delta - immunology ; Receptors, Antigen, T-Cell, gamma-delta - metabolism ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism</subject><ispartof>Immunity (Cambridge, Mass.), 2012-09, Vol.37 (3), p.524-534</ispartof><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><rights>2012 Elsevier Inc. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-90108fade927ac15d3351d54607c4512570350f5b7aed8e86471149362b89cdf3</citedby><cites>FETCH-LOGICAL-c463t-90108fade927ac15d3351d54607c4512570350f5b7aed8e86471149362b89cdf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1074761312003676$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22960222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeng, Xun</creatorcontrib><creatorcontrib>Wei, Yu-Ling</creatorcontrib><creatorcontrib>Huang, Jun</creatorcontrib><creatorcontrib>Newell, Evan W.</creatorcontrib><creatorcontrib>Yu, Hongxiang</creatorcontrib><creatorcontrib>Kidd, Brian A.</creatorcontrib><creatorcontrib>Kuhns, Michael S.</creatorcontrib><creatorcontrib>Waters, Ray W.</creatorcontrib><creatorcontrib>Davis, Mark M.</creatorcontrib><creatorcontrib>Weaver, Casey T.</creatorcontrib><creatorcontrib>Chien, Yueh-hsiu</creatorcontrib><title>γδ T Cells Recognize a Microbial Encoded B Cell Antigen to Initiate a Rapid Antigen-Specific Interleukin-17 Response</title><title>Immunity (Cambridge, Mass.)</title><addtitle>Immunity</addtitle><description>γδ T cells contribute uniquely to immune competence. Nevertheless, how they function remains an enigma. It is unclear what most γδ T cells recognize, what is required for them to mount an immune response, and how the γδ T cell response is integrated into host immune defense. Here, we report that a noted B cell antigen, the algae protein phycoerythrin (PE), is a murine and human γδ T cell antigen. Employing this specificity, we demonstrated that antigen recognition activated naive γδ T cells to make interleukin-17 and respond to cytokine signals that perpetuate the response. High frequencies of antigen-specific γδ T cells in naive animals and their ability to mount effector response without extensive clonal expansion allow γδ T cells to initiate a swift, substantial response. These results underscore the adaptability of lymphocyte antigen receptors and suggest an antigen-driven rapid response in protective immunity prior to the maturation of classical adaptive immunity.
► Murine and human γδ T cells recognize a microbial encoded B cell antigen ► Naive γδ T cells develop into IL-17 effectors in response to this antigen ► Antigen-activated γδ T cells gain the ability to respond to cytokine signals ► Robust and sustained IL-17 production requires both TCR and cytokine signals</description><subject>Algal Proteins - immunology</subject><subject>Algal Proteins - metabolism</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antigens - immunology</subject><subject>Antigens - metabolism</subject><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - metabolism</subject><subject>Base Sequence</subject><subject>Binding Sites - genetics</subject><subject>Cells, Cultured</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Interleukin-17 - genetics</subject><subject>Interleukin-17 - immunology</subject><subject>Interleukin-17 - metabolism</subject><subject>Kinetics</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred NOD</subject><subject>Mice, Transgenic</subject><subject>Phycoerythrin - immunology</subject><subject>Phycoerythrin - metabolism</subject><subject>Protein Binding - immunology</subject><subject>Receptors, Antigen, T-Cell, gamma-delta - genetics</subject><subject>Receptors, Antigen, T-Cell, gamma-delta - immunology</subject><subject>Receptors, Antigen, T-Cell, gamma-delta - metabolism</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><issn>1074-7613</issn><issn>1097-4180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAURSMEoqXwBwh5ySbBdhw72SCVUaGViiqVsrY89svwhsQOcTJS-S34jn5THaYtZcPKlt5599r3ZtlrRgtGmXy3LbDvZ48Fp4wXVBaUsSfZIaONygWr6dPlrkSuJCsPshcxbillomro8-yA80ZSzvlhtrv5dfObXJEVdF0kl2DDxuNPIIZ8RjuGNZqOnHgbHDjy4Q9Fjv2EG_BkCuTM44RmWvBLM6C7n-VfBrDYok3EBGMH83f0OVPJIA7BR3iZPWtNF-HV3XmUff14crU6zc8vPp2tjs9zK2Q55Q1ltG6Ng4YrY1nlyrJirhKSKisqxitFy4q21VoZcDXUUijGRFNKvq4b69ryKHu_1x3mdQ_Ogp9G0-lhxN6M1zoY1P9OPH7Tm7DTpWiqpmZJ4O2dwBh-zBAn3WO0KQbjIcxRLxErWaaMEyr2aMotxhHaBxtG9VKZ3up9ZXqpTFOpU2Vp7c3jJz4s3Xf09w-QgtohjDpaBG_B4Qh20i7g_x1uAUtDqt0</recordid><startdate>20120921</startdate><enddate>20120921</enddate><creator>Zeng, Xun</creator><creator>Wei, Yu-Ling</creator><creator>Huang, Jun</creator><creator>Newell, Evan W.</creator><creator>Yu, Hongxiang</creator><creator>Kidd, Brian A.</creator><creator>Kuhns, Michael S.</creator><creator>Waters, Ray W.</creator><creator>Davis, Mark M.</creator><creator>Weaver, Casey T.</creator><creator>Chien, Yueh-hsiu</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120921</creationdate><title>γδ T Cells Recognize a Microbial Encoded B Cell Antigen to Initiate a Rapid Antigen-Specific Interleukin-17 Response</title><author>Zeng, Xun ; Wei, Yu-Ling ; Huang, Jun ; Newell, Evan W. ; Yu, Hongxiang ; Kidd, Brian A. ; Kuhns, Michael S. ; Waters, Ray W. ; Davis, Mark M. ; Weaver, Casey T. ; Chien, Yueh-hsiu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-90108fade927ac15d3351d54607c4512570350f5b7aed8e86471149362b89cdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Algal Proteins - immunology</topic><topic>Algal Proteins - metabolism</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antigens - immunology</topic><topic>Antigens - metabolism</topic><topic>B-Lymphocytes - immunology</topic><topic>B-Lymphocytes - metabolism</topic><topic>Base Sequence</topic><topic>Binding Sites - genetics</topic><topic>Cells, Cultured</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Interleukin-17 - genetics</topic><topic>Interleukin-17 - immunology</topic><topic>Interleukin-17 - metabolism</topic><topic>Kinetics</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred NOD</topic><topic>Mice, Transgenic</topic><topic>Phycoerythrin - immunology</topic><topic>Phycoerythrin - metabolism</topic><topic>Protein Binding - immunology</topic><topic>Receptors, Antigen, T-Cell, gamma-delta - genetics</topic><topic>Receptors, Antigen, T-Cell, gamma-delta - immunology</topic><topic>Receptors, Antigen, T-Cell, gamma-delta - metabolism</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeng, Xun</creatorcontrib><creatorcontrib>Wei, Yu-Ling</creatorcontrib><creatorcontrib>Huang, Jun</creatorcontrib><creatorcontrib>Newell, Evan W.</creatorcontrib><creatorcontrib>Yu, Hongxiang</creatorcontrib><creatorcontrib>Kidd, Brian A.</creatorcontrib><creatorcontrib>Kuhns, Michael S.</creatorcontrib><creatorcontrib>Waters, Ray W.</creatorcontrib><creatorcontrib>Davis, Mark M.</creatorcontrib><creatorcontrib>Weaver, Casey T.</creatorcontrib><creatorcontrib>Chien, Yueh-hsiu</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunity (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeng, Xun</au><au>Wei, Yu-Ling</au><au>Huang, Jun</au><au>Newell, Evan W.</au><au>Yu, Hongxiang</au><au>Kidd, Brian A.</au><au>Kuhns, Michael S.</au><au>Waters, Ray W.</au><au>Davis, Mark M.</au><au>Weaver, Casey T.</au><au>Chien, Yueh-hsiu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>γδ T Cells Recognize a Microbial Encoded B Cell Antigen to Initiate a Rapid Antigen-Specific Interleukin-17 Response</atitle><jtitle>Immunity (Cambridge, Mass.)</jtitle><addtitle>Immunity</addtitle><date>2012-09-21</date><risdate>2012</risdate><volume>37</volume><issue>3</issue><spage>524</spage><epage>534</epage><pages>524-534</pages><issn>1074-7613</issn><eissn>1097-4180</eissn><abstract>γδ T cells contribute uniquely to immune competence. Nevertheless, how they function remains an enigma. It is unclear what most γδ T cells recognize, what is required for them to mount an immune response, and how the γδ T cell response is integrated into host immune defense. Here, we report that a noted B cell antigen, the algae protein phycoerythrin (PE), is a murine and human γδ T cell antigen. Employing this specificity, we demonstrated that antigen recognition activated naive γδ T cells to make interleukin-17 and respond to cytokine signals that perpetuate the response. High frequencies of antigen-specific γδ T cells in naive animals and their ability to mount effector response without extensive clonal expansion allow γδ T cells to initiate a swift, substantial response. These results underscore the adaptability of lymphocyte antigen receptors and suggest an antigen-driven rapid response in protective immunity prior to the maturation of classical adaptive immunity.
► Murine and human γδ T cells recognize a microbial encoded B cell antigen ► Naive γδ T cells develop into IL-17 effectors in response to this antigen ► Antigen-activated γδ T cells gain the ability to respond to cytokine signals ► Robust and sustained IL-17 production requires both TCR and cytokine signals</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22960222</pmid><doi>10.1016/j.immuni.2012.06.011</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Algal Proteins - immunology Algal Proteins - metabolism Amino Acid Sequence Animals Antigens - immunology Antigens - metabolism B-Lymphocytes - immunology B-Lymphocytes - metabolism Base Sequence Binding Sites - genetics Cells, Cultured Female Flow Cytometry Humans Interleukin-17 - genetics Interleukin-17 - immunology Interleukin-17 - metabolism Kinetics Male Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, Transgenic Phycoerythrin - immunology Phycoerythrin - metabolism Protein Binding - immunology Receptors, Antigen, T-Cell, gamma-delta - genetics Receptors, Antigen, T-Cell, gamma-delta - immunology Receptors, Antigen, T-Cell, gamma-delta - metabolism T-Lymphocytes - immunology T-Lymphocytes - metabolism |
| title | γδ T Cells Recognize a Microbial Encoded B Cell Antigen to Initiate a Rapid Antigen-Specific Interleukin-17 Response |
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