Shape Matters: Intravital Microscopy Reveals Surprising Geometrical Dependence for Nanoparticles in Tumor Models of Extravasation
Delivery is one of the most critical obstacles confronting nanoparticle use in cancer diagnosis and therapy. For most oncological applications, nanoparticles must extravasate in order to reach tumor cells and perform their designated task. However, little understanding exists regarding the effect of...
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| Veröffentlicht in: | Nano letters 2012-07, Vol.12 (7), p.3369-3377 |
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| creator | Smith, Bryan Ronain Kempen, Paul Bouley, Donna Xu, Alexander Liu, Zhuang Melosh, Nicholas Dai, Hongjie Sinclair, Robert Gambhir, Sanjiv Sam |
| description | Delivery is one of the most critical obstacles confronting nanoparticle use in cancer diagnosis and therapy. For most oncological applications, nanoparticles must extravasate in order to reach tumor cells and perform their designated task. However, little understanding exists regarding the effect of nanoparticle shape on extravasation. Herein we use real-time intravital microscopic imaging to meticulously examine how two different nanoparticles behave across three different murine tumor models. The study quantitatively demonstrates that high-aspect ratio single-walled carbon nanotubes (SWNTs) display extravasational behavior surprisingly different from, and counterintuitive to, spherical nanoparticles although the nanoparticles have similar surface coatings, area, and charge. This work quantitatively indicates that nanoscale extravasational competence is highly dependent on nanoparticle geometry and is heterogeneous. |
| doi_str_mv | 10.1021/nl204175t |
| format | Article |
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For most oncological applications, nanoparticles must extravasate in order to reach tumor cells and perform their designated task. However, little understanding exists regarding the effect of nanoparticle shape on extravasation. Herein we use real-time intravital microscopic imaging to meticulously examine how two different nanoparticles behave across three different murine tumor models. The study quantitatively demonstrates that high-aspect ratio single-walled carbon nanotubes (SWNTs) display extravasational behavior surprisingly different from, and counterintuitive to, spherical nanoparticles although the nanoparticles have similar surface coatings, area, and charge. 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For most oncological applications, nanoparticles must extravasate in order to reach tumor cells and perform their designated task. However, little understanding exists regarding the effect of nanoparticle shape on extravasation. Herein we use real-time intravital microscopic imaging to meticulously examine how two different nanoparticles behave across three different murine tumor models. The study quantitatively demonstrates that high-aspect ratio single-walled carbon nanotubes (SWNTs) display extravasational behavior surprisingly different from, and counterintuitive to, spherical nanoparticles although the nanoparticles have similar surface coatings, area, and charge. This work quantitatively indicates that nanoscale extravasational competence is highly dependent on nanoparticle geometry and is heterogeneous.</description><subject>Animals</subject><subject>Charge</subject><subject>Coatings</subject><subject>Condensed matter: structure, mechanical and thermal properties</subject><subject>Cross-disciplinary physics: materials science; rheology</subject><subject>Disease Models, Animal</subject><subject>Ear Neoplasms - blood supply</subject><subject>Ear Neoplasms - pathology</subject><subject>Exact sciences and technology</subject><subject>Humans</subject><subject>Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties</subject><subject>Materials science</subject><subject>Mice</subject><subject>Microscopy</subject><subject>Microscopy, Fluorescence</subject><subject>Nanocrystalline materials</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoscale materials and structures: fabrication and characterization</subject><subject>Nanostructure</subject><subject>Nanotechnology</subject><subject>Nanotubes</subject><subject>Nanotubes, Carbon - chemistry</subject><subject>Neoplasms, Experimental - blood supply</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Particle Size</subject><subject>Physics</subject><subject>Quantum Dots</subject><subject>Real time</subject><subject>Single wall carbon nanotubes</subject><subject>Surface Properties</subject><subject>Surfaces and interfaces; thin films and whiskers (structure and nonelectronic properties)</subject><subject>Tasks</subject><subject>Tumors</subject><issn>1530-6984</issn><issn>1530-6992</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkUtv1DAUhSNERUthwR9A3iDBYqgdP2bCAgmVUip1QKJlbd3YN62rxA62M6JL_jmOOkyp1JUt-zvnPk5VvWL0PaM1O_J9TQVbyvykOmCS04Vqmvrp7r4S-9XzlG4opQ2X9Fm1X9dKzoqD6s_FNYxI1pAzxvSBnPkcYeMy9GTtTAzJhPGW_MANQp_IxRTH6JLzV-QUw4A5OlPIzziit-gNki5E8g18GCFmZ3pMxHlyOQ3leR0sFo_QkZPfcxFIkF3wL6q9rnjjy-15WP38cnJ5_HVx_v307PjT-QIkF3khW0Y5tK0xwK1FaxSVytrOdI2VAlulOG1WrLMghbCtgoK1RWpV1zRLK_lh9fHOd5zaoehxnrTXZZ4B4q0O4PTDH--u9VXYaC4ayVZNMXi7NYjh14Qp68Elg30PHsOUNFuqmkq-ZKuCvrtD5w2miN2uDKN6jkzvIivs6__72pH_MirAmy0AqWy7i-CNS_ecYkIowe85MEnfhCn6ss5HCv4F3a6vlQ</recordid><startdate>20120711</startdate><enddate>20120711</enddate><creator>Smith, Bryan Ronain</creator><creator>Kempen, Paul</creator><creator>Bouley, Donna</creator><creator>Xu, Alexander</creator><creator>Liu, Zhuang</creator><creator>Melosh, Nicholas</creator><creator>Dai, Hongjie</creator><creator>Sinclair, Robert</creator><creator>Gambhir, Sanjiv Sam</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>5PM</scope></search><sort><creationdate>20120711</creationdate><title>Shape Matters: Intravital Microscopy Reveals Surprising Geometrical Dependence for Nanoparticles in Tumor Models of Extravasation</title><author>Smith, Bryan Ronain ; Kempen, Paul ; Bouley, Donna ; Xu, Alexander ; Liu, Zhuang ; Melosh, Nicholas ; Dai, Hongjie ; Sinclair, Robert ; Gambhir, Sanjiv Sam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a534t-5b103abbcca3ddedc6056ddfcf9d54eb6630981fda544db6aa3dba53d6f997d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Charge</topic><topic>Coatings</topic><topic>Condensed matter: structure, mechanical and thermal properties</topic><topic>Cross-disciplinary physics: materials science; rheology</topic><topic>Disease Models, Animal</topic><topic>Ear Neoplasms - blood supply</topic><topic>Ear Neoplasms - pathology</topic><topic>Exact sciences and technology</topic><topic>Humans</topic><topic>Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties</topic><topic>Materials science</topic><topic>Mice</topic><topic>Microscopy</topic><topic>Microscopy, Fluorescence</topic><topic>Nanocrystalline materials</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoscale materials and structures: fabrication and characterization</topic><topic>Nanostructure</topic><topic>Nanotechnology</topic><topic>Nanotubes</topic><topic>Nanotubes, Carbon - chemistry</topic><topic>Neoplasms, Experimental - blood supply</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Particle Size</topic><topic>Physics</topic><topic>Quantum Dots</topic><topic>Real time</topic><topic>Single wall carbon nanotubes</topic><topic>Surface Properties</topic><topic>Surfaces and interfaces; 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| ispartof | Nano letters, 2012-07, Vol.12 (7), p.3369-3377 |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Charge Coatings Condensed matter: structure, mechanical and thermal properties Cross-disciplinary physics: materials science rheology Disease Models, Animal Ear Neoplasms - blood supply Ear Neoplasms - pathology Exact sciences and technology Humans Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties Materials science Mice Microscopy Microscopy, Fluorescence Nanocrystalline materials Nanoparticles Nanoparticles - chemistry Nanoscale materials and structures: fabrication and characterization Nanostructure Nanotechnology Nanotubes Nanotubes, Carbon - chemistry Neoplasms, Experimental - blood supply Neoplasms, Experimental - pathology Particle Size Physics Quantum Dots Real time Single wall carbon nanotubes Surface Properties Surfaces and interfaces thin films and whiskers (structure and nonelectronic properties) Tasks Tumors |
| title | Shape Matters: Intravital Microscopy Reveals Surprising Geometrical Dependence for Nanoparticles in Tumor Models of Extravasation |
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