Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2

Hedgehog （Hh） signaling plays pivotal roles in embryonic development and adult tissue homeostasis in species ranging from Drosophila to mammals. The Hh signal is transduced by Smoothened （Smo）, a seven-transmembrane protein related to G protein coupled receptors. Despite a conserved mechanism by whi...

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Veröffentlicht in:	Cell research 2012-11, Vol.22 (11), p.1593-1604
Hauptverfasser:	Yang, Cuiping, Chen, Wenlin, Chen, Yongbin, Jiang, Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells 631/136 631/80/86 Animals Biomedical and Life Sciences Cell Biology Cell Line Ellis-Van Creveld Syndrome - genetics Embryonic growth stage Hedgehog Hedgehog Proteins - metabolism Humans Kinesin - genetics Kruppel-Like Transcription Factors - metabolism Life Sciences Mammals Membrane Proteins - genetics Membrane Proteins - metabolism Mice Original original-article Phosphorylation Proteins Receptors, G-Protein-Coupled - metabolism RNA Interference RNA, Small Interfering Signal Transduction Smo Smoothened Receptor Zinc Finger Protein GLI1 信号转导受体相关蛋白哺乳动物平滑纤毛蛋白转换器
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