Homeostatic Adaptations in Brain Energy Metabolism in Mouse Models of Huntington Disease

Impairment of energy metabolism is a key feature of Huntington disease (HD). Recently, we reported longitudinal neurochemical changes in R6/2 mice measured by in-vivo proton magnetic resonance spectroscopy (1H MRS; Zacharoff et al, 2012). Here, we present similar 1H MRS measurements at an early stag...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2012-11, Vol.32 (11), p.1977-1988
Hauptverfasser:	Tkac, Ivan, Henry, Pierre-Gilles, Zacharoff, Lori, Wedel, Michael, Gong, Wuming, Deelchand, Dinesh K, Li, Tongbin, Dubinsky, Janet M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptations Adenosine Diphosphate - metabolism Age Algorithms Animal models Animals ATP ATP synthase ATP Synthetase Complexes - metabolism Biological and medical sciences Brain Brain Chemistry - physiology Cerebral blood flow Creatine Creatine kinase Creatine Kinase - metabolism Data processing Disease Models, Animal Energy metabolism Energy Metabolism - physiology Genotype Homeostasis Homeostasis - physiology Humans Huntington Disease - metabolism Huntington Disease - physiopathology Huntington's disease Hydrogen-Ion Concentration Kinetics Magnetic Resonance Spectroscopy Medical sciences Mice Neostriatum Neostriatum - metabolism Neurology Neuropharmacology Neuroprotective agent Original Pharmacology. Drug treatments Phosphate Phosphocreatine Phosphorylation Vascular diseases and vascular malformations of the nervous system
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