Modification of STIM1 by O-linked N-Acetylglucosamine (O-GlcNAc) Attenuates Store-operated Calcium Entry in Neonatal Cardiomyocytes

Store-operated calcium entry (SOCE) is a major Ca2+ signaling pathway responsible for regulating numerous transcriptional events. In cardiomyocytes SOCE has been shown to play an important role in regulating hypertrophic signaling pathways, including nuclear translocation of NFAT. Acute activation o...

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Veröffentlicht in:	The Journal of biological chemistry 2012-11, Vol.287 (46), p.39094-39106
Hauptverfasser:	Zhu-Mauldin, Xiaoyuan, Marsh, Susan A., Zou, Luyun, Marchase, Richard B., Chatham, John C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - metabolism Animals Calcium - metabolism Calcium Signaling Cardiac Metabolism Cardiomyocytes Cell Biology Cell Membrane - metabolism Gene Expression Regulation Heart Heart - physiology Heart Ventricles - metabolism Humans Membrane Glycoproteins - genetics Membrane Glycoproteins - physiology Muscle Cells - cytology Myocardium - metabolism Myocytes, Cardiac - cytology O-GlcNAc Pyrans - pharmacology Rats Rats, Sprague-Dawley Signal Transduction STIM1 Store-operated Calcium Entry Stromal Interaction Molecule 1 Thiazoles - pharmacology
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