14-3-3ϵ and 14-3-3σ Inhibit Toll-like Receptor (TLR)-mediated Proinflammatory Cytokine Induction

Toll-like receptors (TLRs) are a group of pattern recognition receptors that play a crucial role in the induction of the innate immune response against bacterial and viral infections. TLR3 has emerged as a key sensor of viral double-stranded RNA. Thus, a clearer understanding of the biological proce...

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Veröffentlicht in:	The Journal of biological chemistry 2012-11, Vol.287 (46), p.38665-38679
Hauptverfasser:	Butt, Aisha Qasim, Ahmed, Suaad, Maratha, Ashwini, Miggin, Sinéad M.
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - metabolism 14–3-3 Protein CpG Islands Cytokine Cytokines - metabolism Electrophoresis, Gel, Two-Dimensional - methods Gene Expression Regulation HEK293 Cells Humans Immunology Inflammation Mass Spectrometry - methods Models, Biological Myeloid Differentiation Factor 88 - metabolism Negative Regulation Poly I-C - metabolism Proteomics - methods Signal Transduction TLR Signaling Toll-Like Receptors - metabolism
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