Mycobacterium paratuberculosis CobT Activates Dendritic Cells via Engagement of Toll-like Receptor 4 Resulting in Th1 Cell Expansion

Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of Johne disease in animals and MAP involvement in human Crohn disease has been recently emphasized. Evidence from M. tuberculosis studies suggests mycobacterial proteins activate dendritic cells (DCs) via Toll-like receptor (T...

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Veröffentlicht in:	The Journal of biological chemistry 2012-11, Vol.287 (46), p.38609-38624
Hauptverfasser:	Byun, Eui-Hong, Kim, Woo Sik, Kim, Jong-Seok, Won, Choul-Jae, Choi, Han-Gyu, Kim, Hwa-Jung, Cho, Sang-Nae, Lee, Keehoon, Zhang, Tiejun, Hur, Gang Min, Shin, Sung Jae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Proteins - metabolism Dendritic Cells Dendritic Cells - cytology Female Immune System Immunologic Memory Immunology Interferon-gamma - metabolism Memory T Cell Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Models, Biological Multienzyme Complexes - genetics Multienzyme Complexes - physiology Mycobacteria Mycobacterium avium subsp. paratuberculosis Mycobacterium avium subsp. paratuberculosis - metabolism Nucleotidyltransferases - genetics Nucleotidyltransferases - physiology Pentosyltransferases - genetics Pentosyltransferases - physiology Recombinant Proteins - chemistry T Cell T-Lymphocytes - immunology Th1 Cells - cytology Th1 Polarization Toll-like Receptor 4 Toll-Like Receptor 4 - metabolism Toll-like Receptors (TLR)
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