Stress increases periodontal inflammation
This study aimed to examine the effect of chronic restraint stress (RS) on the severity of experimental periodontal disease in rats. A total of 32 male Sprague Dawley (SD) rats were divided into four groups: i) Rats receiving two treatment regimens, chronic stress induced by movement restriction in...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2012-11, Vol.4 (5), p.883-888 |
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| creator | RIVERA, CÉSAR MONSALVE, FRANCISCO SUAZO, IVÁN BECERRA, JAVIERA |
| description | This study aimed to examine the effect of chronic restraint stress (RS) on the severity of experimental periodontal disease in rats. A total of 32 male Sprague Dawley (SD) rats were divided into four groups: i) Rats receiving two treatment regimens, chronic stress induced by movement restriction in acrylic cylinders for 1-1.5 h daily and induction of experimental periodontal disease, using a nylon ligature which was placed around the first left mandibular molars (n=8); ii) induction of periodontal disease, without RS (n=8); iii) RS (n=8) and iv) control (n=8). After 15 days, blood samples were obtained, and blood glucose levels and the corticosterone concentration were measured as stress markers. The severity of periodontal disease was analyzed according to the level of gingival and bone inflammation, leading to compromise of the teeth involved. Chronic stress was induced with movement restriction (P≤0.05, Mann-Whitney U-test) and increased the severity (P≤0.05, Mann-Whitney U-test) of experimental perio dontal disease in rats, according to the level of gingival and bone inflammation around the first left mandibular molars. The results of the present study showed that RS modulates periodontal inflammation and that the rat model described herein is suitable for investigating the association between stress and periodontal disease. |
| doi_str_mv | 10.3892/etm.2012.675 |
| format | Article |
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A total of 32 male Sprague Dawley (SD) rats were divided into four groups: i) Rats receiving two treatment regimens, chronic stress induced by movement restriction in acrylic cylinders for 1-1.5 h daily and induction of experimental periodontal disease, using a nylon ligature which was placed around the first left mandibular molars (n=8); ii) induction of periodontal disease, without RS (n=8); iii) RS (n=8) and iv) control (n=8). After 15 days, blood samples were obtained, and blood glucose levels and the corticosterone concentration were measured as stress markers. The severity of periodontal disease was analyzed according to the level of gingival and bone inflammation, leading to compromise of the teeth involved. Chronic stress was induced with movement restriction (P≤0.05, Mann-Whitney U-test) and increased the severity (P≤0.05, Mann-Whitney U-test) of experimental perio dontal disease in rats, according to the level of gingival and bone inflammation around the first left mandibular molars. The results of the present study showed that RS modulates periodontal inflammation and that the rat model described herein is suitable for investigating the association between stress and periodontal disease.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2012.675</identifier><identifier>PMID: 23226743</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Bones ; gingiva ; Glucose ; Gum disease ; Inflammation ; Laboratory animals ; periodontal disease ; periodontal tissues ; periodontium ; Physiology ; Plasma ; Rodents ; stress ; stress analysis ; Studies</subject><ispartof>Experimental and therapeutic medicine, 2012-11, Vol.4 (5), p.883-888</ispartof><rights>Copyright © 2012, Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2012</rights><rights>Copyright © 2012, Spandidos Publications 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-fa56b38df265ba1d38bd74054c313ece872ad80463a49e2b8c1673973f015ebb3</citedby><cites>FETCH-LOGICAL-c444t-fa56b38df265ba1d38bd74054c313ece872ad80463a49e2b8c1673973f015ebb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493748/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493748/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23226743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RIVERA, CÉSAR</creatorcontrib><creatorcontrib>MONSALVE, FRANCISCO</creatorcontrib><creatorcontrib>SUAZO, IVÁN</creatorcontrib><creatorcontrib>BECERRA, JAVIERA</creatorcontrib><title>Stress increases periodontal inflammation</title><title>Experimental and therapeutic medicine</title><addtitle>Exp Ther Med</addtitle><description>This study aimed to examine the effect of chronic restraint stress (RS) on the severity of experimental periodontal disease in rats. A total of 32 male Sprague Dawley (SD) rats were divided into four groups: i) Rats receiving two treatment regimens, chronic stress induced by movement restriction in acrylic cylinders for 1-1.5 h daily and induction of experimental periodontal disease, using a nylon ligature which was placed around the first left mandibular molars (n=8); ii) induction of periodontal disease, without RS (n=8); iii) RS (n=8) and iv) control (n=8). After 15 days, blood samples were obtained, and blood glucose levels and the corticosterone concentration were measured as stress markers. The severity of periodontal disease was analyzed according to the level of gingival and bone inflammation, leading to compromise of the teeth involved. Chronic stress was induced with movement restriction (P≤0.05, Mann-Whitney U-test) and increased the severity (P≤0.05, Mann-Whitney U-test) of experimental perio dontal disease in rats, according to the level of gingival and bone inflammation around the first left mandibular molars. The results of the present study showed that RS modulates periodontal inflammation and that the rat model described herein is suitable for investigating the association between stress and periodontal disease.</description><subject>Bones</subject><subject>gingiva</subject><subject>Glucose</subject><subject>Gum disease</subject><subject>Inflammation</subject><subject>Laboratory animals</subject><subject>periodontal disease</subject><subject>periodontal tissues</subject><subject>periodontium</subject><subject>Physiology</subject><subject>Plasma</subject><subject>Rodents</subject><subject>stress</subject><subject>stress analysis</subject><subject>Studies</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkUtLAzEUhYMottTuXEvBhQpOzfuxEaT4goILdR0yk4xOmZmMyYzgvzeltajZJNx8HM65B4BjBOdEKnzl-maOIcJzLtgeGCOhcIYgYvvbN1QSjcA0xhVMh3EkJTsEI0ww5oKSMbh47oOLcVa1RXAmujjrXKi89W1v6jQta9M0pq98ewQOSlNHN93eE_B6d_uyeMiWT_ePi5tlVlBK-6w0jOdE2hJzlhtkicytoJDRgiDiCicFNlZCyomhyuFcFogLogQpk22X52QCrje63ZA3zhau7YOpdReqxoQv7U2l__601bt-85-aUEUElUngfCsQ_MfgYq-bKhaurk3r_BA1kskak5TThJ7-Q1d-CG2Kp5EiUCmBxJq63FBF8DEGV-7MIKjXNehUg17XoFMNCT_5HWAH_yw9AWcbIHamtZX1ccckoQzSDLIMSknIN3iSj6s</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>RIVERA, CÉSAR</creator><creator>MONSALVE, FRANCISCO</creator><creator>SUAZO, IVÁN</creator><creator>BECERRA, JAVIERA</creator><general>D.A. Spandidos</general><general>Spandidos Publications UK Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20121101</creationdate><title>Stress increases periodontal inflammation</title><author>RIVERA, CÉSAR ; MONSALVE, FRANCISCO ; SUAZO, IVÁN ; BECERRA, JAVIERA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-fa56b38df265ba1d38bd74054c313ece872ad80463a49e2b8c1673973f015ebb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Bones</topic><topic>gingiva</topic><topic>Glucose</topic><topic>Gum disease</topic><topic>Inflammation</topic><topic>Laboratory animals</topic><topic>periodontal disease</topic><topic>periodontal tissues</topic><topic>periodontium</topic><topic>Physiology</topic><topic>Plasma</topic><topic>Rodents</topic><topic>stress</topic><topic>stress analysis</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RIVERA, CÉSAR</creatorcontrib><creatorcontrib>MONSALVE, FRANCISCO</creatorcontrib><creatorcontrib>SUAZO, IVÁN</creatorcontrib><creatorcontrib>BECERRA, JAVIERA</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental and therapeutic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RIVERA, CÉSAR</au><au>MONSALVE, FRANCISCO</au><au>SUAZO, IVÁN</au><au>BECERRA, JAVIERA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stress increases periodontal inflammation</atitle><jtitle>Experimental and therapeutic medicine</jtitle><addtitle>Exp Ther Med</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>4</volume><issue>5</issue><spage>883</spage><epage>888</epage><pages>883-888</pages><issn>1792-0981</issn><eissn>1792-1015</eissn><abstract>This study aimed to examine the effect of chronic restraint stress (RS) on the severity of experimental periodontal disease in rats. A total of 32 male Sprague Dawley (SD) rats were divided into four groups: i) Rats receiving two treatment regimens, chronic stress induced by movement restriction in acrylic cylinders for 1-1.5 h daily and induction of experimental periodontal disease, using a nylon ligature which was placed around the first left mandibular molars (n=8); ii) induction of periodontal disease, without RS (n=8); iii) RS (n=8) and iv) control (n=8). After 15 days, blood samples were obtained, and blood glucose levels and the corticosterone concentration were measured as stress markers. The severity of periodontal disease was analyzed according to the level of gingival and bone inflammation, leading to compromise of the teeth involved. Chronic stress was induced with movement restriction (P≤0.05, Mann-Whitney U-test) and increased the severity (P≤0.05, Mann-Whitney U-test) of experimental perio dontal disease in rats, according to the level of gingival and bone inflammation around the first left mandibular molars. The results of the present study showed that RS modulates periodontal inflammation and that the rat model described herein is suitable for investigating the association between stress and periodontal disease.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>23226743</pmid><doi>10.3892/etm.2012.675</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Bones gingiva Glucose Gum disease Inflammation Laboratory animals periodontal disease periodontal tissues periodontium Physiology Plasma Rodents stress stress analysis Studies |
| title | Stress increases periodontal inflammation |
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