The genetic prehistory of southern Africa
Southern and eastern African populations that speak non-Bantu languages with click consonants are known to harbour some of the most ancient genetic lineages in humans, but their relationships are poorly understood. Here, we report data from 23 populations analysed at over half a million single-nucle...
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| Veröffentlicht in: | Nature communications 2012, Vol.3 (1), p.1143-1143, Article 1143 |
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| creator | Pickrell, Joseph K. Patterson, Nick Barbieri, Chiara Berthold, Falko Gerlach, Linda Güldemann, Tom Kure, Blesswell Mpoloka, Sununguko Wata Nakagawa, Hirosi Naumann, Christfried Lipson, Mark Loh, Po-Ru Lachance, Joseph Mountain, Joanna Bustamante, Carlos D. Berger, Bonnie Tishkoff, Sarah A. Henn, Brenna M. Stoneking, Mark Reich, David Pakendorf, Brigitte |
| description | Southern and eastern African populations that speak non-Bantu languages with click consonants are known to harbour some of the most ancient genetic lineages in humans, but their relationships are poorly understood. Here, we report data from 23 populations analysed at over half a million single-nucleotide polymorphisms, using a genome-wide array designed for studying human history. The southern African Khoisan fall into two genetic groups, loosely corresponding to the northwestern and southeastern Kalahari, which we show separated within the last 30,000 years. We find that all individuals derive at least a few percent of their genomes from admixture with non-Khoisan populations that began ∼1,200 years ago. In addition, the East African Hadza and Sandawe derive a fraction of their ancestry from admixture with a population related to the Khoisan, supporting the hypothesis of an ancient link between southern and eastern Africa.
Hunter-gatherer populations in Africa preserve unique information about human history, but genetic sub-structures of these populations remain unclear. Using newly designed microarray and statistical methods, these authors analyse genetic compositions of southern African populations and reveal an ancient link between southern and eastern Africa. |
| doi_str_mv | 10.1038/ncomms2140 |
| format | Article |
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Hunter-gatherer populations in Africa preserve unique information about human history, but genetic sub-structures of these populations remain unclear. Using newly designed microarray and statistical methods, these authors analyse genetic compositions of southern African populations and reveal an ancient link between southern and eastern Africa.</description><identifier>ISSN: 2041-1723</identifier><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/ncomms2140</identifier><identifier>PMID: 23072811</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/181/457/649 ; 631/208/457 ; Africa, Southern ; Biological anthropology ; Cluster Analysis ; Databases, Genetic ; Ethnic Groups - genetics ; Gene Pool ; Genetics, Population - history ; History, Ancient ; Humanities and Social Sciences ; Humans ; Linkage Disequilibrium - genetics ; Models, Genetic ; multidisciplinary ; Population Dynamics ; Science ; Science (multidisciplinary)</subject><ispartof>Nature communications, 2012, Vol.3 (1), p.1143-1143, Article 1143</ispartof><rights>The Author(s) 2012</rights><rights>Copyright Nature Publishing Group Oct 2012</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2012, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-78925bb74a6779b7ed3ff2f43c0777cefae4a8344e654476e1674eefd200a4263</citedby><cites>FETCH-LOGICAL-c476t-78925bb74a6779b7ed3ff2f43c0777cefae4a8344e654476e1674eefd200a4263</cites><orcidid>0000-0001-8827-5655 ; 0000-0001-9044-6679</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493647/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493647/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,4010,27904,27905,27906,41101,42170,51557,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23072811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-lyon2.fr/hal-01998848$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Pickrell, Joseph K.</creatorcontrib><creatorcontrib>Patterson, Nick</creatorcontrib><creatorcontrib>Barbieri, Chiara</creatorcontrib><creatorcontrib>Berthold, Falko</creatorcontrib><creatorcontrib>Gerlach, Linda</creatorcontrib><creatorcontrib>Güldemann, Tom</creatorcontrib><creatorcontrib>Kure, Blesswell</creatorcontrib><creatorcontrib>Mpoloka, Sununguko Wata</creatorcontrib><creatorcontrib>Nakagawa, Hirosi</creatorcontrib><creatorcontrib>Naumann, Christfried</creatorcontrib><creatorcontrib>Lipson, Mark</creatorcontrib><creatorcontrib>Loh, Po-Ru</creatorcontrib><creatorcontrib>Lachance, Joseph</creatorcontrib><creatorcontrib>Mountain, Joanna</creatorcontrib><creatorcontrib>Bustamante, Carlos D.</creatorcontrib><creatorcontrib>Berger, Bonnie</creatorcontrib><creatorcontrib>Tishkoff, Sarah A.</creatorcontrib><creatorcontrib>Henn, Brenna M.</creatorcontrib><creatorcontrib>Stoneking, Mark</creatorcontrib><creatorcontrib>Reich, David</creatorcontrib><creatorcontrib>Pakendorf, Brigitte</creatorcontrib><title>The genetic prehistory of southern Africa</title><title>Nature communications</title><addtitle>Nat Commun</addtitle><addtitle>Nat Commun</addtitle><description>Southern and eastern African populations that speak non-Bantu languages with click consonants are known to harbour some of the most ancient genetic lineages in humans, but their relationships are poorly understood. Here, we report data from 23 populations analysed at over half a million single-nucleotide polymorphisms, using a genome-wide array designed for studying human history. The southern African Khoisan fall into two genetic groups, loosely corresponding to the northwestern and southeastern Kalahari, which we show separated within the last 30,000 years. We find that all individuals derive at least a few percent of their genomes from admixture with non-Khoisan populations that began ∼1,200 years ago. In addition, the East African Hadza and Sandawe derive a fraction of their ancestry from admixture with a population related to the Khoisan, supporting the hypothesis of an ancient link between southern and eastern Africa.
Hunter-gatherer populations in Africa preserve unique information about human history, but genetic sub-structures of these populations remain unclear. Using newly designed microarray and statistical methods, these authors analyse genetic compositions of southern African populations and reveal an ancient link between southern and eastern Africa.</description><subject>631/181/457/649</subject><subject>631/208/457</subject><subject>Africa, Southern</subject><subject>Biological anthropology</subject><subject>Cluster Analysis</subject><subject>Databases, Genetic</subject><subject>Ethnic Groups - genetics</subject><subject>Gene Pool</subject><subject>Genetics, Population - history</subject><subject>History, Ancient</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Linkage Disequilibrium - genetics</subject><subject>Models, Genetic</subject><subject>multidisciplinary</subject><subject>Population Dynamics</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2041-1723</issn><issn>2041-1723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkU1LAzEQhoMoWtSLP0AWvPhBNR_TTfYiFFErFLzoOaTppLvS3dRkV_Dfm1KtteYyIfPMO5N5CTlh9JpRoW4a6-s6cgZ0h_Q4BdZnkovdjfsBOY7xjaYjCqYA9skBF1RyxViPXLyUmM2wwbay2SJgWcXWh8_Muyz6ri0xNNnQhcqaI7LnzDzi8Xc8JK8P9y93o_74-fHpbjjuW5B525eq4IPJRILJpSwmEqfCOe5AWCqltOgMglECAPMBpApkuQREN-WUGuC5OCS3K91FN6lxarFpg5nrRahqEz61N5X-m2mqUs_8hxZQiBxkErhYCZRbZaPhWC_fKCsKpUB9sMSefzcL_r3D2Oq6ihbnc9Og76JmjAnOBC2Wsmdb6JvvQpNWkSgoVJ7TwXL6yxVlg48xoFtPwKheGqZ_DUvw6eZX1-iPPQm4WgExpZoZho2e_-W-ALSwnlo</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Pickrell, Joseph K.</creator><creator>Patterson, Nick</creator><creator>Barbieri, Chiara</creator><creator>Berthold, Falko</creator><creator>Gerlach, Linda</creator><creator>Güldemann, Tom</creator><creator>Kure, Blesswell</creator><creator>Mpoloka, Sununguko Wata</creator><creator>Nakagawa, Hirosi</creator><creator>Naumann, Christfried</creator><creator>Lipson, Mark</creator><creator>Loh, Po-Ru</creator><creator>Lachance, Joseph</creator><creator>Mountain, Joanna</creator><creator>Bustamante, Carlos D.</creator><creator>Berger, Bonnie</creator><creator>Tishkoff, Sarah A.</creator><creator>Henn, Brenna M.</creator><creator>Stoneking, Mark</creator><creator>Reich, David</creator><creator>Pakendorf, Brigitte</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Pub. 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| subjects | 631/181/457/649 631/208/457 Africa, Southern Biological anthropology Cluster Analysis Databases, Genetic Ethnic Groups - genetics Gene Pool Genetics, Population - history History, Ancient Humanities and Social Sciences Humans Linkage Disequilibrium - genetics Models, Genetic multidisciplinary Population Dynamics Science Science (multidisciplinary) |
| title | The genetic prehistory of southern Africa |
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