A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

We conducted a genome-wide association study (GWAS) of breast cancer by genotyping 528,173 SNPs in 1,145 postmenopausal women of European ancestry with invasive breast cancer and 1,142 controls. We identified four SNPs in intron 2 of FGFR2 (which encodes a receptor tyrosine kinase and is amplified o...

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Veröffentlicht in:	Nature genetics 2007-07, Vol.39 (7), p.870-874
Hauptverfasser:	Hunter, David J, Kraft, Peter, Jacobs, Kevin B, Cox, David G, Yeager, Meredith, Hankinson, Susan E, Wacholder, Sholom, Wang, Zhaoming, Welch, Robert, Hutchinson, Amy, Wang, Junwen, Yu, Kai, Chatterjee, Nilanjan, Orr, Nick, Willett, Walter C, Colditz, Graham A, Ziegler, Regina G, Berg, Christine D, Buys, Saundra S, McCarty, Catherine A, Feigelson, Heather Spencer, Calle, Eugenia E, Thun, Michael J, Hayes, Richard B, Tucker, Margaret, Gerhard, Daniela S, Fraumeni, Joseph F, Hoover, Robert N, Thomas, Gilles, Chanock, Stephen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Agriculture Alleles Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Cancer Research Diagnosis Female Fundamental and applied biological sciences. Psychology Gene expression Gene Function Genetic aspects Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Genome, Human Genomics Genotype & phenotype Gynecology. Andrology. Obstetrics Health aspects Human Genetics Humans letter Mammary gland diseases Medical sciences Middle Aged Physiological aspects Polymorphism, Single Nucleotide Postmenopausal women Postmenopause Receptor, Fibroblast Growth Factor, Type 2 - genetics Risk Factors Single nucleotide polymorphisms Tumors
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