Fast Identification of Biological Pathways Associated with a Quantitative Trait Using Group Lasso with Overlaps

Where causal SNPs (single nucleotide polymorphisms) tend to accumulate within biological pathways, the incorporation of prior pathways information into a statistical model is expected to increase the power to detect true associations in a genetic association study. Most existing pathways-based metho...

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Veröffentlicht in:	Statistical applications in genetics and molecular biology 2012-01, Vol.11 (1), p.1-43
Hauptverfasser:	Silver, Matt, Montana, Giovanni, Alzheimer's Disease Neuroimaging Initiative
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive algorithms Alzheimer Disease - genetics Alzheimer's disease Bioaccumulation group lasso GWAs Humans imaging genetics Models, Genetic Nucleotides pathways penalised regression Polymorphism, Single Nucleotide Quantitative Trait Loci quantitative traits Regression Analysis Regression models Statistical analysis Statistical models
Online-Zugang:	Volltext
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