FXR signaling in the enterohepatic system

► Bile acids are critical for many hepatic and intestinal and metabolic functions. ► Enterohepatic bile acid circulation is tightly regulated by farnesoid X receptor. ► Farnesoid X receptor controls bile acid synthesis and transport in liver and intestine. ► FGF15/19 hormone production in the intest...

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Veröffentlicht in:	Molecular and cellular endocrinology 2013-04, Vol.368 (1-2), p.17-29
Hauptverfasser:	Matsubara, Tsutomu, Li, Fei, Gonzalez, Frank J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bile Bile acids Bile Acids and Salts - metabolism Biological Transport chenodeoxycholic acid Cholestasis cholesterol cholic acid deoxycholic acid Enterohepatic circulation enzymes Farnesoid X receptor gene expression glucose Homeostasis Humans Intestine, Small - metabolism Ligands lithocholic acid liver Liver - metabolism Liver disease metabolites Neoplasms - metabolism Nuclear receptors pharmacokinetics receptors Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors Receptors, Cytoplasmic and Nuclear - metabolism Signal Transduction small intestine tissues transcription factors transporters vitamin D Xenobiotics - metabolism
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