Macrophage p38 Mitogen-Activated Protein Kinase Activity Regulates Invariant Natural Killer T-Cell Responses During Borrelia burgdorferi Infection

The interaction of macrophages with infectious agents leads to the activation of several signaling cascades, including mitogen-activated protein (MAP) kinases, such as p38. We now demonstrate that p38 MAP kinase-mediated responses are critical components to the immune response to Borrelia burgdorfer...

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Veröffentlicht in:	The Journal of infectious diseases 2012-07, Vol.206 (2), p.283-291
Hauptverfasser:	Hawley, Kelly, Navasa, Nicolás, OlsonJr, Chris M., Bates, Tonya C., Garg, Renu, Hedrick, Michael N., Conze, Dietrich, Rincón, Mercedes, Anguita, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD1d - genetics Antigens, CD1d - metabolism Arthritis BACTERIA Bacteriology Biological and medical sciences Borrelia burgdorferi CD11b Antigen - genetics CD11b Antigen - metabolism Cytokines Fundamental and applied biological sciences. Psychology Gene Expression Regulation Heart Diseases - etiology Heart Diseases - pathology Homeostasis Imidazoles - pharmacology Infections Infectious diseases Inflammation Interferon-gamma - genetics Interferon-gamma - metabolism Killer Cells, Natural - physiology Lyme Disease - complications Lyme Disease - immunology Lyme Disease - pathology Macrophages Macrophages - enzymology Major and Brief Reports Medical sciences Mice Mice, Transgenic Microbiology Miscellaneous Myocarditis Natural killer T cells p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Pyridines - pharmacology Spirochaetales
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