ETS1 regulates the expression of ATXN2

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant disorder caused by the expansion of a CAG tract in the ATXN2 gene. The SCA2 phenotype is characterized by cerebellar ataxia, neuropathy and slow saccades. SCA2 foreshortens life span and is currently without symptomatic or disease-modifyi...

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Veröffentlicht in:	Human molecular genetics 2012-12, Vol.21 (23), p.5048-5065
Hauptverfasser:	SCOLES, Daniel R, PFLIEGER, Lance T, THAI, Khanh K, HANSEN, Stephen T, DANSITHONG, Warunee, PULST, Stefan-M
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animals Ataxins Binding Sites Biological and medical sciences Codon, Initiator Fundamental and applied biological sciences. Psychology Gene Expression Regulation Gene Order Genetic Vectors - genetics Genetics of eukaryotes. Biological and molecular evolution HEK293 Cells Humans Luciferases - genetics Luciferases - metabolism Mice Mice, Transgenic Molecular and cellular biology Mutation Nerve Tissue Proteins - genetics Promoter Regions, Genetic Protein Binding Proto-Oncogene Protein c-ets-1 - genetics Proto-Oncogene Protein c-ets-1 - metabolism Spinocerebellar Ataxias - genetics Spinocerebellar Ataxias - metabolism Trinucleotide Repeat Expansion
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