Serotonin2C receptors in the nucleus accumbens are involved in enhanced alcohol-drinking behavior

Dopamine and serotonin (5‐HT) in the nucleus accumbens (ACC) and ventral tegmental area of the mesoaccumbens reward pathways have been implicated in the mechanisms underlying development of alcohol dependence. We used a C57BL/6J mouse model with increased voluntary alcohol‐drinking behavior by expos...

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Veröffentlicht in:	The European journal of neuroscience 2012-04, Vol.35 (8), p.1368-1380
Hauptverfasser:	Yoshimoto, Kanji, Watanabe, Yoshihisa, Tanaka, Masaki, Kimura, Minoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptations alcohol Alcohol Drinking - pathology Alcohol Drinking - physiopathology Aminopyridines - pharmacology Analysis of Variance Animal models Animals Behavioral Neuroscience Biogenic Monoamines - metabolism Caudate nucleus Central Nervous System Depressants - administration & dosage Central Nervous System Depressants - pharmacology Chromatography, High Pressure Liquid Disease Models, Animal Dopamine dorsal raphe nucleus Drug dependence Ethanol Ethanol - administration & dosage Ethanol - pharmacology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Hippocampus Hypothalamus (lateral) Indoles - pharmacology Male mesoaccumbens reward pathway Mice Mice, Inbred C57BL Microdialysis Microinjections - methods mRNA Nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism nucleus accumbens shell Piperidines - pharmacology Putamen Raphe Nuclei - drug effects Raphe Nuclei - metabolism Receptor, Serotonin, 5-HT2C - genetics Receptor, Serotonin, 5-HT2C - metabolism Receptors, Dopamine - metabolism Reinforcement RNA, Messenger - metabolism Serotonin Serotonin Agents - pharmacology Serotonin receptors Serotonin S2 receptors Serotonin S7 receptors serotonin2C receptor Sulfonamides - pharmacology Vapors Ventral tegmentum
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