Serotonin2C receptors in the nucleus accumbens are involved in enhanced alcohol-drinking behavior
Dopamine and serotonin (5‐HT) in the nucleus accumbens (ACC) and ventral tegmental area of the mesoaccumbens reward pathways have been implicated in the mechanisms underlying development of alcohol dependence. We used a C57BL/6J mouse model with increased voluntary alcohol‐drinking behavior by expos...
Gespeichert in:
| Veröffentlicht in: | The European journal of neuroscience 2012-04, Vol.35 (8), p.1368-1380 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1380 |
|---|---|
| container_issue | 8 |
| container_start_page | 1368 |
| container_title | The European journal of neuroscience |
| container_volume | 35 |
| creator | Yoshimoto, Kanji Watanabe, Yoshihisa Tanaka, Masaki Kimura, Minoru |
| description | Dopamine and serotonin (5‐HT) in the nucleus accumbens (ACC) and ventral tegmental area of the mesoaccumbens reward pathways have been implicated in the mechanisms underlying development of alcohol dependence. We used a C57BL/6J mouse model with increased voluntary alcohol‐drinking behavior by exposing the mice to alcohol vapor for 20 consecutive days. In the alcohol‐exposed mice, the expression of 5‐HT2C receptor mRNA increased in the ACC, caudate nucleus and putamen, dorsal raphe nucleus (DRN), hippocampus and lateral hypothalamus, while the protein level of 5‐HT2C receptor significantly increased in the ACC. The expression of 5‐HT7 receptor mRNA increased in the ACC and DRN. Contents of 5‐HT decreased in the ACC shell (ACCS) and DRN of the alcohol‐exposed mice. The basal extracellular releases of dopamine (DA) and 5‐HT in the ACCS increased more in the alcohol‐exposed mice than in alcohol‐naïve mice. The magnitude of the alcohol‐induced ACCS DA and 5‐HT release in the alcohol‐exposed mice was increased compared with the control mice. Intraperitoneal (i.p.) administration or local injection into ACCS of the 5‐HT2C receptor antagonist, SB‐242084, suppressed voluntary alcohol‐drinking behavior in the alcohol‐exposed mice. But the i.p. administration of the 5‐HT7 receptor antagonist, SB‐258719, did not have significant effects on alcohol‐drinking behavior in the alcohol‐exposed mice. The effects of the 5‐HT2C receptor antagonist were not observed in the air‐exposed control mice. These results suggest that adaptations of the 5‐HT system, especially the upregulation of 5‐HT2C receptors in the ACCS, are involved in the development of enhanced voluntary alcohol‐drinking behavior.
Dopamine and serotonin (5‐HT) in the nucleus accumbens (ACC) and ventral tegmental area of the mesoaccumbens reward pathways have been implicated in the mechanisms underlying development of alcohol dependence. We used a C57BL/6J mouse model with increased voluntary alcohol‐drinking behavior by exposing the mice to alcohol vapor for 20 consecutive days. |
| doi_str_mv | 10.1111/j.1460-9568.2012.08037.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3490368</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1014101538</sourcerecordid><originalsourceid>FETCH-LOGICAL-i4377-2598cfbdec98c49839de9aace98d9af5a491fc03f5703ac7f3ccb766c7b990553</originalsourceid><addsrcrecordid>eNpVUdtu1DAQtRCILoVfQHnkJakvcWI_gISWtnRVFSGubyPHmTTeZu3FSZbt35N0ywosWXOkcxlpDiEJoxmb3tk6Y3lBUy0LlXHKeEYVFWW2f0IWR-IpWVAtRapY8fOEvOj7NaVUFbl8Tk44l4zzgi2I-YIxDME7z5dJRIvbIcQ-cT4ZWkz8aDsc-8RYO24q9BOKOJG70O2wnlXoW-PthE1nQxu6tI7O3zl_m1TYmp0L8SV51piux1eP85R8uzj_uvyYXn-6vFq-v05dLsoy5VIr21Q12mnmWgldozbGola1No00uWaNpaKRJRXGlo2wtiqLwpaV1lRKcUreHXK3Y7XB2qIfoulgG93GxHsIxsH_jHct3IYdiFxTUagp4M1jQAy_RuwH2LjeYtcZj2HsgVGWT1-KWfr6313HJX_vOgneHgS_XYf3R55RmPuDNcw1wVwTzP3BQ3-wh_PVzYwmf3rwu37A_dFv4h0UpSgl_Li5BL5S6vvnlYIP4g87u6Bm</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1014101538</pqid></control><display><type>article</type><title>Serotonin2C receptors in the nucleus accumbens are involved in enhanced alcohol-drinking behavior</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Yoshimoto, Kanji ; Watanabe, Yoshihisa ; Tanaka, Masaki ; Kimura, Minoru</creator><creatorcontrib>Yoshimoto, Kanji ; Watanabe, Yoshihisa ; Tanaka, Masaki ; Kimura, Minoru</creatorcontrib><description>Dopamine and serotonin (5‐HT) in the nucleus accumbens (ACC) and ventral tegmental area of the mesoaccumbens reward pathways have been implicated in the mechanisms underlying development of alcohol dependence. We used a C57BL/6J mouse model with increased voluntary alcohol‐drinking behavior by exposing the mice to alcohol vapor for 20 consecutive days. In the alcohol‐exposed mice, the expression of 5‐HT2C receptor mRNA increased in the ACC, caudate nucleus and putamen, dorsal raphe nucleus (DRN), hippocampus and lateral hypothalamus, while the protein level of 5‐HT2C receptor significantly increased in the ACC. The expression of 5‐HT7 receptor mRNA increased in the ACC and DRN. Contents of 5‐HT decreased in the ACC shell (ACCS) and DRN of the alcohol‐exposed mice. The basal extracellular releases of dopamine (DA) and 5‐HT in the ACCS increased more in the alcohol‐exposed mice than in alcohol‐naïve mice. The magnitude of the alcohol‐induced ACCS DA and 5‐HT release in the alcohol‐exposed mice was increased compared with the control mice. Intraperitoneal (i.p.) administration or local injection into ACCS of the 5‐HT2C receptor antagonist, SB‐242084, suppressed voluntary alcohol‐drinking behavior in the alcohol‐exposed mice. But the i.p. administration of the 5‐HT7 receptor antagonist, SB‐258719, did not have significant effects on alcohol‐drinking behavior in the alcohol‐exposed mice. The effects of the 5‐HT2C receptor antagonist were not observed in the air‐exposed control mice. These results suggest that adaptations of the 5‐HT system, especially the upregulation of 5‐HT2C receptors in the ACCS, are involved in the development of enhanced voluntary alcohol‐drinking behavior.
Dopamine and serotonin (5‐HT) in the nucleus accumbens (ACC) and ventral tegmental area of the mesoaccumbens reward pathways have been implicated in the mechanisms underlying development of alcohol dependence. We used a C57BL/6J mouse model with increased voluntary alcohol‐drinking behavior by exposing the mice to alcohol vapor for 20 consecutive days.</description><identifier>ISSN: 0953-816X</identifier><identifier>EISSN: 1460-9568</identifier><identifier>DOI: 10.1111/j.1460-9568.2012.08037.x</identifier><identifier>PMID: 22512261</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adaptations ; alcohol ; Alcohol Drinking - pathology ; Alcohol Drinking - physiopathology ; Aminopyridines - pharmacology ; Analysis of Variance ; Animal models ; Animals ; Behavioral Neuroscience ; Biogenic Monoamines - metabolism ; Caudate nucleus ; Central Nervous System Depressants - administration & dosage ; Central Nervous System Depressants - pharmacology ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Dopamine ; dorsal raphe nucleus ; Drug dependence ; Ethanol ; Ethanol - administration & dosage ; Ethanol - pharmacology ; Gene Expression Regulation - drug effects ; Gene Expression Regulation - physiology ; Hippocampus ; Hypothalamus (lateral) ; Indoles - pharmacology ; Male ; mesoaccumbens reward pathway ; Mice ; Mice, Inbred C57BL ; Microdialysis ; Microinjections - methods ; mRNA ; Nucleus accumbens ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - metabolism ; nucleus accumbens shell ; Piperidines - pharmacology ; Putamen ; Raphe Nuclei - drug effects ; Raphe Nuclei - metabolism ; Receptor, Serotonin, 5-HT2C - genetics ; Receptor, Serotonin, 5-HT2C - metabolism ; Receptors, Dopamine - metabolism ; Reinforcement ; RNA, Messenger - metabolism ; Serotonin ; Serotonin Agents - pharmacology ; Serotonin receptors ; Serotonin S2 receptors ; Serotonin S7 receptors ; serotonin2C receptor ; Sulfonamides - pharmacology ; Vapors ; Ventral tegmentum</subject><ispartof>The European journal of neuroscience, 2012-04, Vol.35 (8), p.1368-1380</ispartof><rights>2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd</rights><rights>2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.</rights><rights>2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1460-9568.2012.08037.x$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1460-9568.2012.08037.x$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22512261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoshimoto, Kanji</creatorcontrib><creatorcontrib>Watanabe, Yoshihisa</creatorcontrib><creatorcontrib>Tanaka, Masaki</creatorcontrib><creatorcontrib>Kimura, Minoru</creatorcontrib><title>Serotonin2C receptors in the nucleus accumbens are involved in enhanced alcohol-drinking behavior</title><title>The European journal of neuroscience</title><addtitle>Eur J Neurosci</addtitle><description>Dopamine and serotonin (5‐HT) in the nucleus accumbens (ACC) and ventral tegmental area of the mesoaccumbens reward pathways have been implicated in the mechanisms underlying development of alcohol dependence. We used a C57BL/6J mouse model with increased voluntary alcohol‐drinking behavior by exposing the mice to alcohol vapor for 20 consecutive days. In the alcohol‐exposed mice, the expression of 5‐HT2C receptor mRNA increased in the ACC, caudate nucleus and putamen, dorsal raphe nucleus (DRN), hippocampus and lateral hypothalamus, while the protein level of 5‐HT2C receptor significantly increased in the ACC. The expression of 5‐HT7 receptor mRNA increased in the ACC and DRN. Contents of 5‐HT decreased in the ACC shell (ACCS) and DRN of the alcohol‐exposed mice. The basal extracellular releases of dopamine (DA) and 5‐HT in the ACCS increased more in the alcohol‐exposed mice than in alcohol‐naïve mice. The magnitude of the alcohol‐induced ACCS DA and 5‐HT release in the alcohol‐exposed mice was increased compared with the control mice. Intraperitoneal (i.p.) administration or local injection into ACCS of the 5‐HT2C receptor antagonist, SB‐242084, suppressed voluntary alcohol‐drinking behavior in the alcohol‐exposed mice. But the i.p. administration of the 5‐HT7 receptor antagonist, SB‐258719, did not have significant effects on alcohol‐drinking behavior in the alcohol‐exposed mice. The effects of the 5‐HT2C receptor antagonist were not observed in the air‐exposed control mice. These results suggest that adaptations of the 5‐HT system, especially the upregulation of 5‐HT2C receptors in the ACCS, are involved in the development of enhanced voluntary alcohol‐drinking behavior.
Dopamine and serotonin (5‐HT) in the nucleus accumbens (ACC) and ventral tegmental area of the mesoaccumbens reward pathways have been implicated in the mechanisms underlying development of alcohol dependence. We used a C57BL/6J mouse model with increased voluntary alcohol‐drinking behavior by exposing the mice to alcohol vapor for 20 consecutive days.</description><subject>Adaptations</subject><subject>alcohol</subject><subject>Alcohol Drinking - pathology</subject><subject>Alcohol Drinking - physiopathology</subject><subject>Aminopyridines - pharmacology</subject><subject>Analysis of Variance</subject><subject>Animal models</subject><subject>Animals</subject><subject>Behavioral Neuroscience</subject><subject>Biogenic Monoamines - metabolism</subject><subject>Caudate nucleus</subject><subject>Central Nervous System Depressants - administration & dosage</subject><subject>Central Nervous System Depressants - pharmacology</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Disease Models, Animal</subject><subject>Dopamine</subject><subject>dorsal raphe nucleus</subject><subject>Drug dependence</subject><subject>Ethanol</subject><subject>Ethanol - administration & dosage</subject><subject>Ethanol - pharmacology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gene Expression Regulation - physiology</subject><subject>Hippocampus</subject><subject>Hypothalamus (lateral)</subject><subject>Indoles - pharmacology</subject><subject>Male</subject><subject>mesoaccumbens reward pathway</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microdialysis</subject><subject>Microinjections - methods</subject><subject>mRNA</subject><subject>Nucleus accumbens</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - metabolism</subject><subject>nucleus accumbens shell</subject><subject>Piperidines - pharmacology</subject><subject>Putamen</subject><subject>Raphe Nuclei - drug effects</subject><subject>Raphe Nuclei - metabolism</subject><subject>Receptor, Serotonin, 5-HT2C - genetics</subject><subject>Receptor, Serotonin, 5-HT2C - metabolism</subject><subject>Receptors, Dopamine - metabolism</subject><subject>Reinforcement</subject><subject>RNA, Messenger - metabolism</subject><subject>Serotonin</subject><subject>Serotonin Agents - pharmacology</subject><subject>Serotonin receptors</subject><subject>Serotonin S2 receptors</subject><subject>Serotonin S7 receptors</subject><subject>serotonin2C receptor</subject><subject>Sulfonamides - pharmacology</subject><subject>Vapors</subject><subject>Ventral tegmentum</subject><issn>0953-816X</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNpVUdtu1DAQtRCILoVfQHnkJakvcWI_gISWtnRVFSGubyPHmTTeZu3FSZbt35N0ywosWXOkcxlpDiEJoxmb3tk6Y3lBUy0LlXHKeEYVFWW2f0IWR-IpWVAtRapY8fOEvOj7NaVUFbl8Tk44l4zzgi2I-YIxDME7z5dJRIvbIcQ-cT4ZWkz8aDsc-8RYO24q9BOKOJG70O2wnlXoW-PthE1nQxu6tI7O3zl_m1TYmp0L8SV51piux1eP85R8uzj_uvyYXn-6vFq-v05dLsoy5VIr21Q12mnmWgldozbGola1No00uWaNpaKRJRXGlo2wtiqLwpaV1lRKcUreHXK3Y7XB2qIfoulgG93GxHsIxsH_jHct3IYdiFxTUagp4M1jQAy_RuwH2LjeYtcZj2HsgVGWT1-KWfr6313HJX_vOgneHgS_XYf3R55RmPuDNcw1wVwTzP3BQ3-wh_PVzYwmf3rwu37A_dFv4h0UpSgl_Li5BL5S6vvnlYIP4g87u6Bm</recordid><startdate>201204</startdate><enddate>201204</enddate><creator>Yoshimoto, Kanji</creator><creator>Watanabe, Yoshihisa</creator><creator>Tanaka, Masaki</creator><creator>Kimura, Minoru</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>201204</creationdate><title>Serotonin2C receptors in the nucleus accumbens are involved in enhanced alcohol-drinking behavior</title><author>Yoshimoto, Kanji ; Watanabe, Yoshihisa ; Tanaka, Masaki ; Kimura, Minoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i4377-2598cfbdec98c49839de9aace98d9af5a491fc03f5703ac7f3ccb766c7b990553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adaptations</topic><topic>alcohol</topic><topic>Alcohol Drinking - pathology</topic><topic>Alcohol Drinking - physiopathology</topic><topic>Aminopyridines - pharmacology</topic><topic>Analysis of Variance</topic><topic>Animal models</topic><topic>Animals</topic><topic>Behavioral Neuroscience</topic><topic>Biogenic Monoamines - metabolism</topic><topic>Caudate nucleus</topic><topic>Central Nervous System Depressants - administration & dosage</topic><topic>Central Nervous System Depressants - pharmacology</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Disease Models, Animal</topic><topic>Dopamine</topic><topic>dorsal raphe nucleus</topic><topic>Drug dependence</topic><topic>Ethanol</topic><topic>Ethanol - administration & dosage</topic><topic>Ethanol - pharmacology</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Gene Expression Regulation - physiology</topic><topic>Hippocampus</topic><topic>Hypothalamus (lateral)</topic><topic>Indoles - pharmacology</topic><topic>Male</topic><topic>mesoaccumbens reward pathway</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microdialysis</topic><topic>Microinjections - methods</topic><topic>mRNA</topic><topic>Nucleus accumbens</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Nucleus Accumbens - metabolism</topic><topic>nucleus accumbens shell</topic><topic>Piperidines - pharmacology</topic><topic>Putamen</topic><topic>Raphe Nuclei - drug effects</topic><topic>Raphe Nuclei - metabolism</topic><topic>Receptor, Serotonin, 5-HT2C - genetics</topic><topic>Receptor, Serotonin, 5-HT2C - metabolism</topic><topic>Receptors, Dopamine - metabolism</topic><topic>Reinforcement</topic><topic>RNA, Messenger - metabolism</topic><topic>Serotonin</topic><topic>Serotonin Agents - pharmacology</topic><topic>Serotonin receptors</topic><topic>Serotonin S2 receptors</topic><topic>Serotonin S7 receptors</topic><topic>serotonin2C receptor</topic><topic>Sulfonamides - pharmacology</topic><topic>Vapors</topic><topic>Ventral tegmentum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshimoto, Kanji</creatorcontrib><creatorcontrib>Watanabe, Yoshihisa</creatorcontrib><creatorcontrib>Tanaka, Masaki</creatorcontrib><creatorcontrib>Kimura, Minoru</creatorcontrib><collection>Istex</collection><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The European journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshimoto, Kanji</au><au>Watanabe, Yoshihisa</au><au>Tanaka, Masaki</au><au>Kimura, Minoru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serotonin2C receptors in the nucleus accumbens are involved in enhanced alcohol-drinking behavior</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>2012-04</date><risdate>2012</risdate><volume>35</volume><issue>8</issue><spage>1368</spage><epage>1380</epage><pages>1368-1380</pages><issn>0953-816X</issn><eissn>1460-9568</eissn><abstract>Dopamine and serotonin (5‐HT) in the nucleus accumbens (ACC) and ventral tegmental area of the mesoaccumbens reward pathways have been implicated in the mechanisms underlying development of alcohol dependence. We used a C57BL/6J mouse model with increased voluntary alcohol‐drinking behavior by exposing the mice to alcohol vapor for 20 consecutive days. In the alcohol‐exposed mice, the expression of 5‐HT2C receptor mRNA increased in the ACC, caudate nucleus and putamen, dorsal raphe nucleus (DRN), hippocampus and lateral hypothalamus, while the protein level of 5‐HT2C receptor significantly increased in the ACC. The expression of 5‐HT7 receptor mRNA increased in the ACC and DRN. Contents of 5‐HT decreased in the ACC shell (ACCS) and DRN of the alcohol‐exposed mice. The basal extracellular releases of dopamine (DA) and 5‐HT in the ACCS increased more in the alcohol‐exposed mice than in alcohol‐naïve mice. The magnitude of the alcohol‐induced ACCS DA and 5‐HT release in the alcohol‐exposed mice was increased compared with the control mice. Intraperitoneal (i.p.) administration or local injection into ACCS of the 5‐HT2C receptor antagonist, SB‐242084, suppressed voluntary alcohol‐drinking behavior in the alcohol‐exposed mice. But the i.p. administration of the 5‐HT7 receptor antagonist, SB‐258719, did not have significant effects on alcohol‐drinking behavior in the alcohol‐exposed mice. The effects of the 5‐HT2C receptor antagonist were not observed in the air‐exposed control mice. These results suggest that adaptations of the 5‐HT system, especially the upregulation of 5‐HT2C receptors in the ACCS, are involved in the development of enhanced voluntary alcohol‐drinking behavior.
Dopamine and serotonin (5‐HT) in the nucleus accumbens (ACC) and ventral tegmental area of the mesoaccumbens reward pathways have been implicated in the mechanisms underlying development of alcohol dependence. We used a C57BL/6J mouse model with increased voluntary alcohol‐drinking behavior by exposing the mice to alcohol vapor for 20 consecutive days.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22512261</pmid><doi>10.1111/j.1460-9568.2012.08037.x</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0953-816X |
| ispartof | The European journal of neuroscience, 2012-04, Vol.35 (8), p.1368-1380 |
| issn | 0953-816X 1460-9568 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3490368 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adaptations alcohol Alcohol Drinking - pathology Alcohol Drinking - physiopathology Aminopyridines - pharmacology Analysis of Variance Animal models Animals Behavioral Neuroscience Biogenic Monoamines - metabolism Caudate nucleus Central Nervous System Depressants - administration & dosage Central Nervous System Depressants - pharmacology Chromatography, High Pressure Liquid Disease Models, Animal Dopamine dorsal raphe nucleus Drug dependence Ethanol Ethanol - administration & dosage Ethanol - pharmacology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Hippocampus Hypothalamus (lateral) Indoles - pharmacology Male mesoaccumbens reward pathway Mice Mice, Inbred C57BL Microdialysis Microinjections - methods mRNA Nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism nucleus accumbens shell Piperidines - pharmacology Putamen Raphe Nuclei - drug effects Raphe Nuclei - metabolism Receptor, Serotonin, 5-HT2C - genetics Receptor, Serotonin, 5-HT2C - metabolism Receptors, Dopamine - metabolism Reinforcement RNA, Messenger - metabolism Serotonin Serotonin Agents - pharmacology Serotonin receptors Serotonin S2 receptors Serotonin S7 receptors serotonin2C receptor Sulfonamides - pharmacology Vapors Ventral tegmentum |
| title | Serotonin2C receptors in the nucleus accumbens are involved in enhanced alcohol-drinking behavior |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T01%3A56%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serotonin2C%20receptors%20in%20the%20nucleus%20accumbens%20are%20involved%20in%20enhanced%20alcohol-drinking%20behavior&rft.jtitle=The%20European%20journal%20of%20neuroscience&rft.au=Yoshimoto,%20Kanji&rft.date=2012-04&rft.volume=35&rft.issue=8&rft.spage=1368&rft.epage=1380&rft.pages=1368-1380&rft.issn=0953-816X&rft.eissn=1460-9568&rft_id=info:doi/10.1111/j.1460-9568.2012.08037.x&rft_dat=%3Cproquest_pubme%3E1014101538%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1014101538&rft_id=info:pmid/22512261&rfr_iscdi=true |