Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome
Pathogenic simian immunodeficiency virus (SIV) infection is associated with enteropathy, which likely contributes to AIDS progression. To identify candidate etiologies for AIDS enteropathy, we used next-generation sequencing to define the enteric virome during SIV infection in nonhuman primates. Pat...
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Veröffentlicht in: | Cell 2012-10, Vol.151 (2), p.253-266 |
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creator | Handley, Scott A. Thackray, Larissa B. Zhao, Guoyan Presti, Rachel Miller, Andrew D. Droit, Lindsay Abbink, Peter Maxfield, Lori F. Kambal, Amal Duan, Erning Stanley, Kelly Kramer, Joshua Macri, Sheila C. Permar, Sallie R. Schmitz, Joern E. Mansfield, Keith Brenchley, Jason M. Veazey, Ronald S. Stappenbeck, Thaddeus S. Wang, David Barouch, Dan H. Virgin, Herbert W. |
description | Pathogenic simian immunodeficiency virus (SIV) infection is associated with enteropathy, which likely contributes to AIDS progression. To identify candidate etiologies for AIDS enteropathy, we used next-generation sequencing to define the enteric virome during SIV infection in nonhuman primates. Pathogenic, but not nonpathogenic, SIV infection was associated with significant expansion of the enteric virome. We identified at least 32 previously undescribed enteric viruses during pathogenic SIV infection and confirmed their presence by using viral culture and PCR testing. We detected unsuspected mucosal adenovirus infection associated with enteritis as well as parvovirus viremia in animals with advanced AIDS, indicating the pathogenic potential of SIV-associated expansion of the enteric virome. No association between pathogenic SIV infection and the family-level taxonomy of enteric bacteria was detected. Thus, enteric viral infections may contribute to AIDS enteropathy and disease progression. These findings underline the importance of metagenomic analysis of the virome for understanding AIDS pathogenesis.
[Display omitted]
► The enteric virome expands during pathogenic, but not nonpathogenic, SIV infection ► Pathogenic SIV-infected rhesus monkeys shed multiple enteric viruses ► Viruses are associated with intestinal pathology during SIV infection ► Metagenomic analysis of the enteric virome is important to study AIDS pathogenesis
Monkeys infected with pathogenic SIV manifest an expanded enteric virome that includes examples of previously uncharacterized viruses. Viruses within the cohort are associated with intestinal damage, suggesting a link to the intestinal pathologies that develop in HIV-infected patients. |
doi_str_mv | 10.1016/j.cell.2012.09.024 |
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[Display omitted]
► The enteric virome expands during pathogenic, but not nonpathogenic, SIV infection ► Pathogenic SIV-infected rhesus monkeys shed multiple enteric viruses ► Viruses are associated with intestinal pathology during SIV infection ► Metagenomic analysis of the enteric virome is important to study AIDS pathogenesis
Monkeys infected with pathogenic SIV manifest an expanded enteric virome that includes examples of previously uncharacterized viruses. Viruses within the cohort are associated with intestinal damage, suggesting a link to the intestinal pathologies that develop in HIV-infected patients.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/j.cell.2012.09.024</identifier><identifier>PMID: 23063120</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adenoviridae infections ; Animals ; Caliciviridae - classification ; Caliciviridae - genetics ; Caliciviridae - isolation & purification ; Cercopithecus aethiops ; disease course ; enteritis ; Feces - microbiology ; Feces - virology ; high-throughput nucleotide sequencing ; intestinal microorganisms ; Intestines - microbiology ; Intestines - virology ; metagenomics ; Molecular Sequence Data ; Parvoviridae - classification ; Parvoviridae - genetics ; Parvoviridae - isolation & purification ; pathogenesis ; Phylogeny ; Picornaviridae - classification ; Picornaviridae - genetics ; Picornaviridae - isolation & purification ; Polymerase Chain Reaction ; Primates ; Simian Acquired Immunodeficiency Syndrome - microbiology ; Simian Acquired Immunodeficiency Syndrome - virology ; Simian immunodeficiency virus ; Simian Immunodeficiency Virus - pathogenicity ; Simian Immunodeficiency Virus - physiology ; taxonomy ; viremia ; viruses</subject><ispartof>Cell, 2012-10, Vol.151 (2), p.253-266</ispartof><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><rights>2012 Elsevier Inc. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-52ce52bd25e01613fa2d6b7eceaf2038d026fb18ec0feaad02b39c92ddcefefa3</citedby><cites>FETCH-LOGICAL-c479t-52ce52bd25e01613fa2d6b7eceaf2038d026fb18ec0feaad02b39c92ddcefefa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cell.2012.09.024$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23063120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Handley, Scott A.</creatorcontrib><creatorcontrib>Thackray, Larissa B.</creatorcontrib><creatorcontrib>Zhao, Guoyan</creatorcontrib><creatorcontrib>Presti, Rachel</creatorcontrib><creatorcontrib>Miller, Andrew D.</creatorcontrib><creatorcontrib>Droit, Lindsay</creatorcontrib><creatorcontrib>Abbink, Peter</creatorcontrib><creatorcontrib>Maxfield, Lori F.</creatorcontrib><creatorcontrib>Kambal, Amal</creatorcontrib><creatorcontrib>Duan, Erning</creatorcontrib><creatorcontrib>Stanley, Kelly</creatorcontrib><creatorcontrib>Kramer, Joshua</creatorcontrib><creatorcontrib>Macri, Sheila C.</creatorcontrib><creatorcontrib>Permar, Sallie R.</creatorcontrib><creatorcontrib>Schmitz, Joern E.</creatorcontrib><creatorcontrib>Mansfield, Keith</creatorcontrib><creatorcontrib>Brenchley, Jason M.</creatorcontrib><creatorcontrib>Veazey, Ronald S.</creatorcontrib><creatorcontrib>Stappenbeck, Thaddeus S.</creatorcontrib><creatorcontrib>Wang, David</creatorcontrib><creatorcontrib>Barouch, Dan H.</creatorcontrib><creatorcontrib>Virgin, Herbert W.</creatorcontrib><title>Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome</title><title>Cell</title><addtitle>Cell</addtitle><description>Pathogenic simian immunodeficiency virus (SIV) infection is associated with enteropathy, which likely contributes to AIDS progression. To identify candidate etiologies for AIDS enteropathy, we used next-generation sequencing to define the enteric virome during SIV infection in nonhuman primates. Pathogenic, but not nonpathogenic, SIV infection was associated with significant expansion of the enteric virome. We identified at least 32 previously undescribed enteric viruses during pathogenic SIV infection and confirmed their presence by using viral culture and PCR testing. We detected unsuspected mucosal adenovirus infection associated with enteritis as well as parvovirus viremia in animals with advanced AIDS, indicating the pathogenic potential of SIV-associated expansion of the enteric virome. No association between pathogenic SIV infection and the family-level taxonomy of enteric bacteria was detected. Thus, enteric viral infections may contribute to AIDS enteropathy and disease progression. These findings underline the importance of metagenomic analysis of the virome for understanding AIDS pathogenesis.
[Display omitted]
► The enteric virome expands during pathogenic, but not nonpathogenic, SIV infection ► Pathogenic SIV-infected rhesus monkeys shed multiple enteric viruses ► Viruses are associated with intestinal pathology during SIV infection ► Metagenomic analysis of the enteric virome is important to study AIDS pathogenesis
Monkeys infected with pathogenic SIV manifest an expanded enteric virome that includes examples of previously uncharacterized viruses. Viruses within the cohort are associated with intestinal damage, suggesting a link to the intestinal pathologies that develop in HIV-infected patients.</description><subject>Adenoviridae infections</subject><subject>Animals</subject><subject>Caliciviridae - classification</subject><subject>Caliciviridae - genetics</subject><subject>Caliciviridae - isolation & purification</subject><subject>Cercopithecus aethiops</subject><subject>disease course</subject><subject>enteritis</subject><subject>Feces - microbiology</subject><subject>Feces - virology</subject><subject>high-throughput nucleotide sequencing</subject><subject>intestinal microorganisms</subject><subject>Intestines - microbiology</subject><subject>Intestines - virology</subject><subject>metagenomics</subject><subject>Molecular Sequence Data</subject><subject>Parvoviridae - classification</subject><subject>Parvoviridae - genetics</subject><subject>Parvoviridae - isolation & purification</subject><subject>pathogenesis</subject><subject>Phylogeny</subject><subject>Picornaviridae - classification</subject><subject>Picornaviridae - genetics</subject><subject>Picornaviridae - isolation & purification</subject><subject>Polymerase Chain Reaction</subject><subject>Primates</subject><subject>Simian Acquired Immunodeficiency Syndrome - microbiology</subject><subject>Simian Acquired Immunodeficiency Syndrome - virology</subject><subject>Simian immunodeficiency virus</subject><subject>Simian Immunodeficiency Virus - pathogenicity</subject><subject>Simian Immunodeficiency Virus - physiology</subject><subject>taxonomy</subject><subject>viremia</subject><subject>viruses</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9vEzEQxS0EoqHwBTiAj1x2GXv_ZSWEVFUBIlWiUluultceJ46ydrC9pf329ZJSwYWTZc97b8bzI-Qtg5IBaz_uSoX7fcmB8RL6Enj9jCwY9F1Rs44_JwuAnhfLtqtPyKsYdwCwbJrmJTnhFbQV47AgeCnT1m_QWUWv7Gilo-txnJzXaKyy6NQ9_WHDFOnaGVTJ-iyI9CxGr6xMqOkvm7Z0dXeQLs5Fb2jaIl25hCFnZq8f8TV5YeQ-4pvH85TcfFldn38rLr5_XZ-fXRSq7vpUNFxhwwfNG8z_Y5WRXLdDhwql4VAtNfDWDGyJCgxKma9D1auea63QoJHVKfl8zD1Mw4j51aUg9-IQ7CjDvfDSin8rzm7Fxt-Kqu6B9W0O-PAYEPzPCWMSo43zlqVDP0XBGONV3UDXZCk_SlXwMQY0T20YiJmP2InZKWY-AnqR-WTTu78HfLL8AZIF748CI72Qm2CjuLnKCW2GB23TzRGfjgrMi7y1GET8zQm1DRmQ0N7-b4IHKimuRg</recordid><startdate>20121012</startdate><enddate>20121012</enddate><creator>Handley, Scott A.</creator><creator>Thackray, Larissa B.</creator><creator>Zhao, Guoyan</creator><creator>Presti, Rachel</creator><creator>Miller, Andrew D.</creator><creator>Droit, Lindsay</creator><creator>Abbink, Peter</creator><creator>Maxfield, Lori F.</creator><creator>Kambal, Amal</creator><creator>Duan, Erning</creator><creator>Stanley, Kelly</creator><creator>Kramer, Joshua</creator><creator>Macri, Sheila C.</creator><creator>Permar, Sallie R.</creator><creator>Schmitz, Joern E.</creator><creator>Mansfield, Keith</creator><creator>Brenchley, Jason M.</creator><creator>Veazey, Ronald S.</creator><creator>Stappenbeck, Thaddeus S.</creator><creator>Wang, David</creator><creator>Barouch, Dan H.</creator><creator>Virgin, Herbert W.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20121012</creationdate><title>Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome</title><author>Handley, Scott A. ; Thackray, Larissa B. ; Zhao, Guoyan ; Presti, Rachel ; Miller, Andrew D. ; Droit, Lindsay ; Abbink, Peter ; Maxfield, Lori F. ; Kambal, Amal ; Duan, Erning ; Stanley, Kelly ; Kramer, Joshua ; Macri, Sheila C. ; Permar, Sallie R. ; Schmitz, Joern E. ; Mansfield, Keith ; Brenchley, Jason M. ; Veazey, Ronald S. ; Stappenbeck, Thaddeus S. ; Wang, David ; Barouch, Dan H. ; Virgin, Herbert W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-52ce52bd25e01613fa2d6b7eceaf2038d026fb18ec0feaad02b39c92ddcefefa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adenoviridae infections</topic><topic>Animals</topic><topic>Caliciviridae - classification</topic><topic>Caliciviridae - genetics</topic><topic>Caliciviridae - isolation & purification</topic><topic>Cercopithecus aethiops</topic><topic>disease course</topic><topic>enteritis</topic><topic>Feces - microbiology</topic><topic>Feces - virology</topic><topic>high-throughput nucleotide sequencing</topic><topic>intestinal microorganisms</topic><topic>Intestines - microbiology</topic><topic>Intestines - virology</topic><topic>metagenomics</topic><topic>Molecular Sequence Data</topic><topic>Parvoviridae - classification</topic><topic>Parvoviridae - genetics</topic><topic>Parvoviridae - isolation & purification</topic><topic>pathogenesis</topic><topic>Phylogeny</topic><topic>Picornaviridae - classification</topic><topic>Picornaviridae - genetics</topic><topic>Picornaviridae - isolation & purification</topic><topic>Polymerase Chain Reaction</topic><topic>Primates</topic><topic>Simian Acquired Immunodeficiency Syndrome - microbiology</topic><topic>Simian Acquired Immunodeficiency Syndrome - virology</topic><topic>Simian immunodeficiency virus</topic><topic>Simian Immunodeficiency Virus - pathogenicity</topic><topic>Simian Immunodeficiency Virus - physiology</topic><topic>taxonomy</topic><topic>viremia</topic><topic>viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Handley, Scott A.</creatorcontrib><creatorcontrib>Thackray, Larissa B.</creatorcontrib><creatorcontrib>Zhao, Guoyan</creatorcontrib><creatorcontrib>Presti, Rachel</creatorcontrib><creatorcontrib>Miller, Andrew D.</creatorcontrib><creatorcontrib>Droit, Lindsay</creatorcontrib><creatorcontrib>Abbink, Peter</creatorcontrib><creatorcontrib>Maxfield, Lori F.</creatorcontrib><creatorcontrib>Kambal, Amal</creatorcontrib><creatorcontrib>Duan, Erning</creatorcontrib><creatorcontrib>Stanley, Kelly</creatorcontrib><creatorcontrib>Kramer, Joshua</creatorcontrib><creatorcontrib>Macri, Sheila C.</creatorcontrib><creatorcontrib>Permar, Sallie R.</creatorcontrib><creatorcontrib>Schmitz, Joern E.</creatorcontrib><creatorcontrib>Mansfield, Keith</creatorcontrib><creatorcontrib>Brenchley, Jason M.</creatorcontrib><creatorcontrib>Veazey, Ronald S.</creatorcontrib><creatorcontrib>Stappenbeck, Thaddeus S.</creatorcontrib><creatorcontrib>Wang, David</creatorcontrib><creatorcontrib>Barouch, Dan H.</creatorcontrib><creatorcontrib>Virgin, Herbert W.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Handley, Scott A.</au><au>Thackray, Larissa B.</au><au>Zhao, Guoyan</au><au>Presti, Rachel</au><au>Miller, Andrew D.</au><au>Droit, Lindsay</au><au>Abbink, Peter</au><au>Maxfield, Lori F.</au><au>Kambal, Amal</au><au>Duan, Erning</au><au>Stanley, Kelly</au><au>Kramer, Joshua</au><au>Macri, Sheila C.</au><au>Permar, Sallie R.</au><au>Schmitz, Joern E.</au><au>Mansfield, Keith</au><au>Brenchley, Jason M.</au><au>Veazey, Ronald S.</au><au>Stappenbeck, Thaddeus S.</au><au>Wang, David</au><au>Barouch, Dan H.</au><au>Virgin, Herbert W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2012-10-12</date><risdate>2012</risdate><volume>151</volume><issue>2</issue><spage>253</spage><epage>266</epage><pages>253-266</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Pathogenic simian immunodeficiency virus (SIV) infection is associated with enteropathy, which likely contributes to AIDS progression. To identify candidate etiologies for AIDS enteropathy, we used next-generation sequencing to define the enteric virome during SIV infection in nonhuman primates. Pathogenic, but not nonpathogenic, SIV infection was associated with significant expansion of the enteric virome. We identified at least 32 previously undescribed enteric viruses during pathogenic SIV infection and confirmed their presence by using viral culture and PCR testing. We detected unsuspected mucosal adenovirus infection associated with enteritis as well as parvovirus viremia in animals with advanced AIDS, indicating the pathogenic potential of SIV-associated expansion of the enteric virome. No association between pathogenic SIV infection and the family-level taxonomy of enteric bacteria was detected. Thus, enteric viral infections may contribute to AIDS enteropathy and disease progression. These findings underline the importance of metagenomic analysis of the virome for understanding AIDS pathogenesis.
[Display omitted]
► The enteric virome expands during pathogenic, but not nonpathogenic, SIV infection ► Pathogenic SIV-infected rhesus monkeys shed multiple enteric viruses ► Viruses are associated with intestinal pathology during SIV infection ► Metagenomic analysis of the enteric virome is important to study AIDS pathogenesis
Monkeys infected with pathogenic SIV manifest an expanded enteric virome that includes examples of previously uncharacterized viruses. Viruses within the cohort are associated with intestinal damage, suggesting a link to the intestinal pathologies that develop in HIV-infected patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23063120</pmid><doi>10.1016/j.cell.2012.09.024</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adenoviridae infections Animals Caliciviridae - classification Caliciviridae - genetics Caliciviridae - isolation & purification Cercopithecus aethiops disease course enteritis Feces - microbiology Feces - virology high-throughput nucleotide sequencing intestinal microorganisms Intestines - microbiology Intestines - virology metagenomics Molecular Sequence Data Parvoviridae - classification Parvoviridae - genetics Parvoviridae - isolation & purification pathogenesis Phylogeny Picornaviridae - classification Picornaviridae - genetics Picornaviridae - isolation & purification Polymerase Chain Reaction Primates Simian Acquired Immunodeficiency Syndrome - microbiology Simian Acquired Immunodeficiency Syndrome - virology Simian immunodeficiency virus Simian Immunodeficiency Virus - pathogenicity Simian Immunodeficiency Virus - physiology taxonomy viremia viruses |
title | Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome |
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