Epigenetic obstacles encountered by transcription factors: reprogramming against all odds
Reprogramming of a somatic nucleus to an induced pluripotent state can be achieved in vitro through ectopic expression of Oct4 (Pou5f1), Sox2, Klf4 and c-Myc. While the ability of these factors to regulate transcription in a pluripotent context has been studied extensively, their ability to interact...
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| Veröffentlicht in: | Current opinion in genetics & development 2012-10, Vol.22 (5), p.409-415 |
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| container_title | Current opinion in genetics & development |
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| creator | Gifford, Casey A Meissner, Alexander |
| description | Reprogramming of a somatic nucleus to an induced pluripotent state can be achieved in vitro through ectopic expression of Oct4 (Pou5f1), Sox2, Klf4 and c-Myc. While the ability of these factors to regulate transcription in a pluripotent context has been studied extensively, their ability to interact with and remodel a somatic genome remains underexplored. Several recent studies have begun to provide mechanistic insights that will eventually lead to a more rational design and improved understanding of nuclear reprogramming. |
| doi_str_mv | 10.1016/j.gde.2012.08.002 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0959-437X |
| ispartof | Current opinion in genetics & development, 2012-10, Vol.22 (5), p.409-415 |
| issn | 0959-437X 1879-0380 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell Differentiation Cellular Reprogramming DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epigenesis, Genetic Gene Expression Regulation Humans Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Medical Education Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Transcription Factors - genetics Transcription Factors - metabolism |
| title | Epigenetic obstacles encountered by transcription factors: reprogramming against all odds |
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