Inhibition of d-xylose isomerase by polyols: atomic details by joint X-ray/neutron crystallography

d‐Xylose isomerase (XI) converts the aldo‐sugars xylose and glucose to their keto analogs xylulose and fructose, but is strongly inhibited by the polyols xylitol and sorbitol, especially at acidic pH. In order to understand the atomic details of polyol binding to the XI active site, a 2.0 Å resoluti...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta crystallographica. Section D, Biological crystallography. Biological crystallography., 2012-09, Vol.68 (9), p.1201-1206
Hauptverfasser:	Kovalevsky, Andrey, Hanson, B. Leif, Mason, Sax A., Forsyth, V. Trevor, Fisher, Zoe, Mustyakimov, Marat, Blakeley, Matthew P., Keen, David A., Langan, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	AFFINITY Aldose-Ketose Isomerases - antagonists & inhibitors Aldose-Ketose Isomerases - chemistry Atomic structure ATOMS Binding CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY CRYSTALLOGRAPHY Crystallography, X-Ray d-xylose isomerase DENSITY Enzyme Inhibitors - chemistry Enzymes GLUCOSE HYDRATION Inhibitors INTERACTIONS joint X-ray/neutron crystallography metalloenzymes METALS Models, Molecular Neutron Diffraction NEUTRONS NUCLEAR MATTER OXYGEN Polymers - chemistry Polyols Protein Interaction Domains and Motifs protonation Research Papers RESOLUTION SACCHAROSE Sorbitol Streptococcus - enzymology WATER X-rays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!