Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjögren's syndrome
Objectives To determine the prevalence of autonomic dysfunction (dysautonomia) among patients with primary Sjögren's syndrome (PSS) and the relationships between dysautonomia and other clinical features of PSS. Methods Multicentre, prospective, cross-sectional study of a UK cohort of 317 patien...
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| Veröffentlicht in: | Annals of the rheumatic diseases 2012-12, Vol.71 (12), p.1973-1979 |
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| container_end_page | 1979 |
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| container_title | Annals of the rheumatic diseases |
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| creator | Newton, Julia L Frith, James Powell, Danielle Hackett, Kate Wilton, Katharine Bowman, Simon Price, Elizabeth Pease, Colin Andrews, Jacqueline Emery, Paul Hunter, John Gupta, Monica Vadivelu, Saravanan Giles, Ian Isenberg, David Lanyon, Peter Jones, Adrian Regan, Marian Cooper, Annie Moots, Robert Sutcliffe, Nurhan Bombardieri, Michele Pitzalis, Costantino McLaren, John Young-Min, Steven Dasgupta, Bhaskar Griffiths, Bridget Lendrem, Dennis Mitchell, Sheryl Ng, Wan-Fai |
| description | Objectives To determine the prevalence of autonomic dysfunction (dysautonomia) among patients with primary Sjögren's syndrome (PSS) and the relationships between dysautonomia and other clinical features of PSS. Methods Multicentre, prospective, cross-sectional study of a UK cohort of 317 patients with clinically well-characterised PSS. Symptoms of autonomic dysfunction were assessed using a validated instrument, the Composite Autonomic Symptom Scale (COMPASS). The data were compared with an age- and sex-matched cohort of 317 community controls. The relationships between symptoms of dysautonomia and various clinical features of PSS were analysed using regression analysis. Results COMPASS scores were significantly higher in patients with PSS than in age- and sex-matched community controls (median (IQR) 35.5 (20.9–46.0) vs 14.8 (4.4–30.2), p |
| doi_str_mv | 10.1136/annrheumdis-2011-201009 |
| format | Article |
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Methods Multicentre, prospective, cross-sectional study of a UK cohort of 317 patients with clinically well-characterised PSS. Symptoms of autonomic dysfunction were assessed using a validated instrument, the Composite Autonomic Symptom Scale (COMPASS). The data were compared with an age- and sex-matched cohort of 317 community controls. The relationships between symptoms of dysautonomia and various clinical features of PSS were analysed using regression analysis. Results COMPASS scores were significantly higher in patients with PSS than in age- and sex-matched community controls (median (IQR) 35.5 (20.9–46.0) vs 14.8 (4.4–30.2), p<0.0001). Nearly 55% of patients (vs 20% of community controls, p<0.0001) had a COMPASS score >32.5, a cut-off value indicative of autonomic dysfunction. Furthermore, the COMPASS total score correlated independently with EULAR Sjögren's Syndrome Patient Reported Index (a composite measure of the overall burden of symptoms experienced by patients with PSS) (β=0.38, p<0.001) and disease activity measured using the EULAR Sjögren's Syndrome Disease Activity Index (β=0.13, p<0.009). Conclusions Autonomic symptoms are common among patients with PSS and may contribute to the overall burden of symptoms and link with systemic disease activity.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/annrheumdis-2011-201009</identifier><identifier>PMID: 22562982</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Aged ; Autonomic Nervous System Diseases - epidemiology ; Autonomic Nervous System Diseases - physiopathology ; Bias ; Biological and medical sciences ; Biomedical research ; Clinical and Epidemiological Research ; Cost of Illness ; Cross-Sectional Studies ; Datasets ; Disease ; Diseases of the osteoarticular system ; Ethics ; Fatigue ; Female ; Humans ; Laboratories ; Male ; Medical research ; Medical sciences ; Middle Aged ; Multivariate analysis ; Nervous system ; Prevalence ; Prospective Studies ; Questionnaires ; Regression Analysis ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Severity of Illness Index ; Sjogren's Syndrome - epidemiology ; Sjogren's Syndrome - physiopathology ; Studies ; United Kingdom - epidemiology ; Variables</subject><ispartof>Annals of the rheumatic diseases, 2012-12, Vol.71 (12), p.1973-1979</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2012 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b626t-e1a5afe50f6ef57391002fffd74b1a24d8abaf3a38fbd1a60c3b5201ee7450603</citedby><cites>FETCH-LOGICAL-b626t-e1a5afe50f6ef57391002fffd74b1a24d8abaf3a38fbd1a60c3b5201ee7450603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/71/12/1973.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/71/12/1973.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>114,115,230,314,776,780,881,3183,23550,27901,27902,77569,77600</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26580572$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22562982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Newton, Julia L</creatorcontrib><creatorcontrib>Frith, James</creatorcontrib><creatorcontrib>Powell, Danielle</creatorcontrib><creatorcontrib>Hackett, Kate</creatorcontrib><creatorcontrib>Wilton, Katharine</creatorcontrib><creatorcontrib>Bowman, Simon</creatorcontrib><creatorcontrib>Price, Elizabeth</creatorcontrib><creatorcontrib>Pease, Colin</creatorcontrib><creatorcontrib>Andrews, Jacqueline</creatorcontrib><creatorcontrib>Emery, Paul</creatorcontrib><creatorcontrib>Hunter, John</creatorcontrib><creatorcontrib>Gupta, Monica</creatorcontrib><creatorcontrib>Vadivelu, Saravanan</creatorcontrib><creatorcontrib>Giles, Ian</creatorcontrib><creatorcontrib>Isenberg, David</creatorcontrib><creatorcontrib>Lanyon, Peter</creatorcontrib><creatorcontrib>Jones, Adrian</creatorcontrib><creatorcontrib>Regan, Marian</creatorcontrib><creatorcontrib>Cooper, Annie</creatorcontrib><creatorcontrib>Moots, Robert</creatorcontrib><creatorcontrib>Sutcliffe, Nurhan</creatorcontrib><creatorcontrib>Bombardieri, Michele</creatorcontrib><creatorcontrib>Pitzalis, Costantino</creatorcontrib><creatorcontrib>McLaren, John</creatorcontrib><creatorcontrib>Young-Min, Steven</creatorcontrib><creatorcontrib>Dasgupta, Bhaskar</creatorcontrib><creatorcontrib>Griffiths, Bridget</creatorcontrib><creatorcontrib>Lendrem, Dennis</creatorcontrib><creatorcontrib>Mitchell, Sheryl</creatorcontrib><creatorcontrib>Ng, Wan-Fai</creatorcontrib><creatorcontrib>UK primary Sjögren's syndrome registry</creatorcontrib><title>Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjögren's syndrome</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>Objectives To determine the prevalence of autonomic dysfunction (dysautonomia) among patients with primary Sjögren's syndrome (PSS) and the relationships between dysautonomia and other clinical features of PSS. Methods Multicentre, prospective, cross-sectional study of a UK cohort of 317 patients with clinically well-characterised PSS. Symptoms of autonomic dysfunction were assessed using a validated instrument, the Composite Autonomic Symptom Scale (COMPASS). The data were compared with an age- and sex-matched cohort of 317 community controls. The relationships between symptoms of dysautonomia and various clinical features of PSS were analysed using regression analysis. Results COMPASS scores were significantly higher in patients with PSS than in age- and sex-matched community controls (median (IQR) 35.5 (20.9–46.0) vs 14.8 (4.4–30.2), p<0.0001). Nearly 55% of patients (vs 20% of community controls, p<0.0001) had a COMPASS score >32.5, a cut-off value indicative of autonomic dysfunction. Furthermore, the COMPASS total score correlated independently with EULAR Sjögren's Syndrome Patient Reported Index (a composite measure of the overall burden of symptoms experienced by patients with PSS) (β=0.38, p<0.001) and disease activity measured using the EULAR Sjögren's Syndrome Disease Activity Index (β=0.13, p<0.009). Conclusions Autonomic symptoms are common among patients with PSS and may contribute to the overall burden of symptoms and link with systemic disease activity.</description><subject>Aged</subject><subject>Autonomic Nervous System Diseases - epidemiology</subject><subject>Autonomic Nervous System Diseases - physiopathology</subject><subject>Bias</subject><subject>Biological and medical sciences</subject><subject>Biomedical research</subject><subject>Clinical and Epidemiological Research</subject><subject>Cost of Illness</subject><subject>Cross-Sectional Studies</subject><subject>Datasets</subject><subject>Disease</subject><subject>Diseases of the osteoarticular system</subject><subject>Ethics</subject><subject>Fatigue</subject><subject>Female</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Nervous system</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Questionnaires</subject><subject>Regression Analysis</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Severity of Illness Index</subject><subject>Sjogren's Syndrome - epidemiology</subject><subject>Sjogren's Syndrome - physiopathology</subject><subject>Studies</subject><subject>United Kingdom - epidemiology</subject><subject>Variables</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkcuO0zAUhiMEYsrAK0AkhGAT8CW-dIM0qmAGqeIiLgs21kliT11iu9hJoTueihfgxXBJpxpYsbF1dL7_6D_nL4oHGD3FmPJn4H1c6dF1NlUEYbx_EJrfKGa45jJXHN0sZgghWtVzLk6KOymtc4kklreLE0IYJ3NJZsWPs3EIPjjblmnnNkNwqYSoyzY4F3wJvvtTQkqhtTDorvxmh1UZtjpC319pymaMnZ7wbElDypJ2sFs77Erry020DuKufL_-9fMyav84ZaXvYnD6bnHLQJ_0vcN_Wnx8-eLD4qJavjl_tThbVg0nfKg0BgZGM2S4NkzQeV6XGGM6UTcYSN1JaMBQoNI0HQaOWtqwfBStRc3yNehp8Xyauxkbp7tW-yFvoA7OVACr_u54u1KXYatoLaXgdR7w5DAghq-jToNyNrW678HrMCaFicgoo4Rl9OE_6DqM0ef1FBZCSDHPbKbERLUxpBS1OZrBSO1TVtdSVvuU1ZRyVt6_vstRdxVrBh4dAEgt9CaCb_OMI8eZREzsuWribBr092Mf4hfFBRVMvf60UOfvPr-lF3ypeObJxDdu_d9ufwN_3dfZ</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Newton, Julia L</creator><creator>Frith, James</creator><creator>Powell, Danielle</creator><creator>Hackett, Kate</creator><creator>Wilton, Katharine</creator><creator>Bowman, Simon</creator><creator>Price, Elizabeth</creator><creator>Pease, Colin</creator><creator>Andrews, Jacqueline</creator><creator>Emery, Paul</creator><creator>Hunter, John</creator><creator>Gupta, Monica</creator><creator>Vadivelu, Saravanan</creator><creator>Giles, Ian</creator><creator>Isenberg, David</creator><creator>Lanyon, Peter</creator><creator>Jones, Adrian</creator><creator>Regan, Marian</creator><creator>Cooper, Annie</creator><creator>Moots, Robert</creator><creator>Sutcliffe, Nurhan</creator><creator>Bombardieri, Michele</creator><creator>Pitzalis, Costantino</creator><creator>McLaren, John</creator><creator>Young-Min, Steven</creator><creator>Dasgupta, Bhaskar</creator><creator>Griffiths, Bridget</creator><creator>Lendrem, Dennis</creator><creator>Mitchell, Sheryl</creator><creator>Ng, Wan-Fai</creator><general>BMJ Publishing Group Ltd and European League Against Rheumatism</general><general>BMJ Publishing Group</general><general>Elsevier Limited</general><general>BMJ Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20121201</creationdate><title>Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjögren's syndrome</title><author>Newton, Julia L ; Frith, James ; Powell, Danielle ; Hackett, Kate ; Wilton, Katharine ; Bowman, Simon ; Price, Elizabeth ; Pease, Colin ; Andrews, Jacqueline ; Emery, Paul ; Hunter, John ; Gupta, Monica ; Vadivelu, Saravanan ; Giles, Ian ; Isenberg, David ; Lanyon, Peter ; Jones, Adrian ; Regan, Marian ; Cooper, Annie ; Moots, Robert ; Sutcliffe, Nurhan ; Bombardieri, Michele ; Pitzalis, Costantino ; McLaren, John ; Young-Min, Steven ; Dasgupta, Bhaskar ; Griffiths, Bridget ; Lendrem, Dennis ; Mitchell, Sheryl ; Ng, Wan-Fai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b626t-e1a5afe50f6ef57391002fffd74b1a24d8abaf3a38fbd1a60c3b5201ee7450603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Autonomic Nervous System Diseases - epidemiology</topic><topic>Autonomic Nervous System Diseases - physiopathology</topic><topic>Bias</topic><topic>Biological and medical sciences</topic><topic>Biomedical research</topic><topic>Clinical and Epidemiological Research</topic><topic>Cost of Illness</topic><topic>Cross-Sectional Studies</topic><topic>Datasets</topic><topic>Disease</topic><topic>Diseases of the osteoarticular system</topic><topic>Ethics</topic><topic>Fatigue</topic><topic>Female</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Nervous system</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Questionnaires</topic><topic>Regression Analysis</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Severity of Illness Index</topic><topic>Sjogren's Syndrome - epidemiology</topic><topic>Sjogren's Syndrome - physiopathology</topic><topic>Studies</topic><topic>United Kingdom - epidemiology</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Newton, Julia L</creatorcontrib><creatorcontrib>Frith, James</creatorcontrib><creatorcontrib>Powell, Danielle</creatorcontrib><creatorcontrib>Hackett, Kate</creatorcontrib><creatorcontrib>Wilton, Katharine</creatorcontrib><creatorcontrib>Bowman, Simon</creatorcontrib><creatorcontrib>Price, Elizabeth</creatorcontrib><creatorcontrib>Pease, Colin</creatorcontrib><creatorcontrib>Andrews, Jacqueline</creatorcontrib><creatorcontrib>Emery, Paul</creatorcontrib><creatorcontrib>Hunter, John</creatorcontrib><creatorcontrib>Gupta, Monica</creatorcontrib><creatorcontrib>Vadivelu, Saravanan</creatorcontrib><creatorcontrib>Giles, Ian</creatorcontrib><creatorcontrib>Isenberg, David</creatorcontrib><creatorcontrib>Lanyon, Peter</creatorcontrib><creatorcontrib>Jones, Adrian</creatorcontrib><creatorcontrib>Regan, Marian</creatorcontrib><creatorcontrib>Cooper, Annie</creatorcontrib><creatorcontrib>Moots, Robert</creatorcontrib><creatorcontrib>Sutcliffe, Nurhan</creatorcontrib><creatorcontrib>Bombardieri, Michele</creatorcontrib><creatorcontrib>Pitzalis, Costantino</creatorcontrib><creatorcontrib>McLaren, John</creatorcontrib><creatorcontrib>Young-Min, Steven</creatorcontrib><creatorcontrib>Dasgupta, Bhaskar</creatorcontrib><creatorcontrib>Griffiths, Bridget</creatorcontrib><creatorcontrib>Lendrem, Dennis</creatorcontrib><creatorcontrib>Mitchell, Sheryl</creatorcontrib><creatorcontrib>Ng, Wan-Fai</creatorcontrib><creatorcontrib>UK primary Sjögren's syndrome registry</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Newton, Julia L</au><au>Frith, James</au><au>Powell, Danielle</au><au>Hackett, Kate</au><au>Wilton, Katharine</au><au>Bowman, Simon</au><au>Price, Elizabeth</au><au>Pease, Colin</au><au>Andrews, Jacqueline</au><au>Emery, Paul</au><au>Hunter, John</au><au>Gupta, Monica</au><au>Vadivelu, Saravanan</au><au>Giles, Ian</au><au>Isenberg, David</au><au>Lanyon, Peter</au><au>Jones, Adrian</au><au>Regan, Marian</au><au>Cooper, Annie</au><au>Moots, Robert</au><au>Sutcliffe, Nurhan</au><au>Bombardieri, Michele</au><au>Pitzalis, Costantino</au><au>McLaren, John</au><au>Young-Min, Steven</au><au>Dasgupta, Bhaskar</au><au>Griffiths, Bridget</au><au>Lendrem, Dennis</au><au>Mitchell, Sheryl</au><au>Ng, Wan-Fai</au><aucorp>UK primary Sjögren's syndrome registry</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjögren's syndrome</atitle><jtitle>Annals of the rheumatic diseases</jtitle><addtitle>Ann Rheum Dis</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>71</volume><issue>12</issue><spage>1973</spage><epage>1979</epage><pages>1973-1979</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>Objectives To determine the prevalence of autonomic dysfunction (dysautonomia) among patients with primary Sjögren's syndrome (PSS) and the relationships between dysautonomia and other clinical features of PSS. Methods Multicentre, prospective, cross-sectional study of a UK cohort of 317 patients with clinically well-characterised PSS. Symptoms of autonomic dysfunction were assessed using a validated instrument, the Composite Autonomic Symptom Scale (COMPASS). The data were compared with an age- and sex-matched cohort of 317 community controls. The relationships between symptoms of dysautonomia and various clinical features of PSS were analysed using regression analysis. Results COMPASS scores were significantly higher in patients with PSS than in age- and sex-matched community controls (median (IQR) 35.5 (20.9–46.0) vs 14.8 (4.4–30.2), p<0.0001). Nearly 55% of patients (vs 20% of community controls, p<0.0001) had a COMPASS score >32.5, a cut-off value indicative of autonomic dysfunction. Furthermore, the COMPASS total score correlated independently with EULAR Sjögren's Syndrome Patient Reported Index (a composite measure of the overall burden of symptoms experienced by patients with PSS) (β=0.38, p<0.001) and disease activity measured using the EULAR Sjögren's Syndrome Disease Activity Index (β=0.13, p<0.009). Conclusions Autonomic symptoms are common among patients with PSS and may contribute to the overall burden of symptoms and link with systemic disease activity.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and European League Against Rheumatism</pub><pmid>22562982</pmid><doi>10.1136/annrheumdis-2011-201009</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-4967 |
| ispartof | Annals of the rheumatic diseases, 2012-12, Vol.71 (12), p.1973-1979 |
| issn | 0003-4967 1468-2060 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3488764 |
| source | MEDLINE; BMJ Journals - NESLi2 |
| subjects | Aged Autonomic Nervous System Diseases - epidemiology Autonomic Nervous System Diseases - physiopathology Bias Biological and medical sciences Biomedical research Clinical and Epidemiological Research Cost of Illness Cross-Sectional Studies Datasets Disease Diseases of the osteoarticular system Ethics Fatigue Female Humans Laboratories Male Medical research Medical sciences Middle Aged Multivariate analysis Nervous system Prevalence Prospective Studies Questionnaires Regression Analysis Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Severity of Illness Index Sjogren's Syndrome - epidemiology Sjogren's Syndrome - physiopathology Studies United Kingdom - epidemiology Variables |
| title | Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjögren's syndrome |
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