HIV Nonnucleoside Reverse Transcriptase Inhibitors and Trimethoprim-Sulfamethoxazole Inhibit Plasmodium Liver Stages

Background. Although nonnucleoside reverse transcriptase inhibitors (NNRTIs) are usually part of first-line treatment regimens for human immunodeficiency virus (HIV), their activity on Plasmodium liver stages remains unexplored. Additionally, trimethoprim-sulfamethoxazole (TMP-SMX), used for opportu...

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Veröffentlicht in:	The Journal of infectious diseases 2012-12, Vol.206 (11), p.1706-1714
Hauptverfasser:	Hobbs, Charlotte V., Voza, Tatiana, De La Vega, Patricia, Vanvliet, Jillian, Conteh, Solomon, Penzak, Scott R., Fay, Michael P., Anders, Nicole, Ilmet, Tiina, Li, Yonghua, Borkowsky, William, Krzych, Urszula, Duffy, Patrick E., Sinnis, Photini
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - administration & dosage Antimalarials - pharmacology Biological and medical sciences Blood Dosage Female Fundamental and applied biological sciences. Psychology HIV HIV/AIDS Human immunodeficiency virus Humans Infections Infectious diseases Liver Liver - parasitology Major and Brief Reports Malaria Malaria - drug therapy Malaria - parasitology Medical sciences Mice Microbiology Miscellaneous Parasitemia - drug therapy Parasites Plasmodium - drug effects Plasmodium berghei Plasmodium falciparum Plasmodium yoelii Reverse transcriptase inhibitors Reverse Transcriptase Inhibitors - administration & dosage Reverse Transcriptase Inhibitors - pharmacology Rodents Species Specificity Sporozoites Trimethoprim, Sulfamethoxazole Drug Combination - administration & dosage Trimethoprim, Sulfamethoxazole Drug Combination - pharmacology Virology
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