Malectin Forms a Complex with Ribophorin I for Enhanced Association with Misfolded Glycoproteins

Malectin is an endoplasmic reticulum-resident lectin, which recognizes di-glucosylated Glc2Man9GlcNAc2 (G2M9) N-glycans on newly synthesized glycoproteins. We previously demonstrated that malectin preferentially associates with misfolded glycoproteins and inhibits their secretion (Chen, Y., Hu, D.,...

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Veröffentlicht in:	The Journal of biological chemistry 2012-11, Vol.287 (45), p.38080-38089
Hauptverfasser:	Qin, Sheng-Ying, Hu, Dan, Matsumoto, Kana, Takeda, Koh, Matsumoto, Naoki, Yamaguchi, Yoshiki, Yamamoto, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha 1-Antitrypsin - chemistry alpha 1-Antitrypsin - genetics alpha 1-Antitrypsin - metabolism Amino Acid Sequence Blotting, Western Chaperone Chaperonin Endoplasmic Reticulum - metabolism Glycobiology Glycobiology and Extracellular Matrices Glycoprotein Glycoprotein Biosynthesis Glycoprotein Quality Control Glycoproteins - chemistry Glycoproteins - genetics Glycoproteins - metabolism HEK293 Cells Humans Immunoprecipitation Lectin Lectins - genetics Lectins - metabolism Malectin Membrane Proteins - genetics Membrane Proteins - metabolism Molecular Sequence Data Mutation Polysaccharides - metabolism Protein Binding Protein Folding Ribophorin I RNA Interference Spectrometry, Fluorescence Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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