Intracellular and Extracellular ATP Coordinately Regulate the Inverse Correlation between Osteoclast Survival and Bone Resorption

Osteoclasts, highly differentiated bone-resorbing cells of hematopoietic origin, have two conflicting tendencies: a lower capacity to survive and a higher capacity to execute energy-consuming activities such as bone resorption. Here, we report that when compared with their precursors, mature mitocho...

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Veröffentlicht in:	The Journal of biological chemistry 2012-11, Vol.287 (45), p.37808-37823
Hauptverfasser:	Miyazaki, Tsuyoshi, Iwasawa, Mitsuyasu, Nakashima, Tomoki, Mori, Shuuichi, Shigemoto, Kazuhiro, Nakamura, Hiroaki, Katagiri, Hideki, Takayanagi, Hiroshi, Tanaka, Sakae
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Aging Animals Apoptosis - genetics ATP bcl-X Protein - genetics bcl-X Protein - metabolism Blotting, Western Body Size - genetics Bone Resorption - metabolism Cell Biology Cell Survival Cells, Cultured DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Down-Regulation - drug effects Extracellular Space - metabolism Female High Mobility Group Proteins - genetics High Mobility Group Proteins - metabolism Intracellular Space - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial DNA Osteoclast Osteoclasts - metabolism RANK Ligand - pharmacology Receptors, Purinergic P2X7 - genetics Receptors, Purinergic P2X7 - metabolism RNA Interference Tfam
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