New functional degradable and bio-compatible nanoparticles based on poly(malic acid) derivatives for site-specific anti-cancer drug delivery

Design of an efficient site-specific drug delivery system based on degradable functional polymers still remains challenging. In this work, we synthesized and characterized three degradable functional polyesters belonging to the poly(malic acid) family: the poly(benzyl malate) (PMLABe), the poly(ethy...

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Veröffentlicht in:	International journal of pharmaceutics 2012-02, Vol.423 (1), p.84-92
Hauptverfasser:	Huang, Zhi Wei, Laurent, Véronique, Chetouani, Ghizlane, Ljubimova, Julia Y., Holler, Eggehard, Benvegnu, Thierry, Loyer, Pascal, Cammas-Marion, Sandrine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Biotin Biotin - chemistry Cancer Carbocyanines Carbocyanines - administration & dosage Carbocyanines - metabolism Cell Line, Transformed Cell Line, Tumor Cell Survival Cell Survival - drug effects Cytotoxicity Degradable functional nanoparticles Degradable polyesters Doxorubicin Doxorubicin - administration & dosage Doxorubicin - pharmacology Drug delivery Drug Delivery Systems Drug Delivery Systems - methods Drug development ethylene glycol Fibroblasts Fibroblasts - cytology Fibroblasts - drug effects fluorescence Fluorescent Dyes Fluorescent Dyes - administration & dosage Fluorescent Dyes - metabolism Fluorescent indicators Human health and pathology Humans Hépatology and Gastroenterology In vitro cellular uptake In vitro cytotoxicity Life Sciences Malates Malates - chemistry malic acid Mice MMT Molecular Structure Nanoparticles Nanoparticles - chemistry Nanoparticles - toxicity Oil Particle Size Poly(malic acid) derivatives polyesters Polyethylene Glycols Polyethylene Glycols - chemistry Polymers Polymers - chemical synthesis Polymers - chemistry Static Electricity Surface Properties Toxicity Tumor cell lines
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