Genetic Variants at 6p21.1 and 7p15.3 Are Associated with Risk of Multiple Cancers in Han Chinese

Cancer susceptibility loci identified in reported genome-wide association studies (GWAS) are often tumor-specific; however, evidence of pleiotropy of some genes/loci has also been observed and biologically plausible. We hypothesized that there are important regions in the genome harboring genetic va...

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Veröffentlicht in:	American journal of human genetics 2012-11, Vol.91 (5), p.928-934
Hauptverfasser:	Jin, Guangfu, Ma, Hongxia, Wu, Chen, Dai, Juncheng, Zhang, Ruyang, Shi, Yongyong, Lu, Jiachun, Miao, Xiaoping, Wang, Meilin, Zhou, Yifeng, Chen, Jiaping, Li, Huizhang, Pan, Shandong, Chu, Minjie, Lu, Feng, Yu, Dianke, Jiang, Yue, Dong, Jing, Hu, Lingmin, Chen, Yijiang, Xu, Lin, Shu, Yongqian, Pan, Shiyang, Tan, Wen, Zhou, Baosen, Lu, Daru, Wu, Tangchun, Zhang, Zhengdong, Chen, Feng, Wang, Xinru, Hu, Zhibin, Lin, Dongxin, Shen, Hongbing
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Asian Continental Ancestry Group - genetics Biological and medical sciences Cancer Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - genetics China - epidemiology Chromosomes, Human, Pair 6 Chromosomes, Human, Pair 7 Esophageal Neoplasms - epidemiology Esophageal Neoplasms - genetics Female Fundamental and applied biological sciences. Psychology Genes Genetic Predisposition to Disease Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Genomes Humans Lung Neoplasms - epidemiology Lung Neoplasms - genetics Male Medical genetics Medical sciences Middle Aged Molecular and cellular biology Neoplasms, Multiple Primary - epidemiology Neoplasms, Multiple Primary - genetics Risk Risk assessment Stomach Neoplasms - epidemiology Stomach Neoplasms - genetics Tumors
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