Experimental venous thrombi: MRI characteristics with histopathological correlation
The purpose of this study was to evaluate the MRI characteristics of venous thrombus over set time thresholds with histopathological correlation in a porcine model. Inferior vena cava thrombi were induced in 12 pigs. MRI was performed in three pigs 2 h, 1 day, 3 days and 2 weeks after thrombus induc...
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| Veröffentlicht in: | British journal of radiology 2012-04, Vol.85 (1012), p.331-338 |
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| creator | ICHIKI, M SAKAI, Y MIKI, Y NANGO, M NAKAMURA, K MATSUI, H CHO, H KITAYAMA, T SAHARA, T OTANI, N INOUE, Y |
| description | The purpose of this study was to evaluate the MRI characteristics of venous thrombus over set time thresholds with histopathological correlation in a porcine model.
Inferior vena cava thrombi were induced in 12 pigs. MRI was performed in three pigs 2 h, 1 day, 3 days and 2 weeks after thrombus induction.
The MRI characteristics were analysed in correlation with histopathological findings. The thrombi after 2 hours, which consisted of red blood cells (RBCs), showed isointensity on T(1 )weighted images (T(1)WIs) and hyperintensity on both T(2 )weighted images (T(2)WIs) and diffusion-weighted images (DWIs). The mean apparent diffusion coefficient (ADC) value was 1.93 × 10(-3) mm(2) s(-1). The thrombi after Day 1, which consisted of RBCs and migrating neutrophils at the periphery, showed isointensity on T(1)WIs, slight hyperintensity on T(2)WIs and hypointensity on DWIs. The mean ADC value was 1.62 × 10(-3) mm(2) s(-1) [corrected]. The thrombi after Day 3, which consisted of RBCs and peripheral inflammatory cells including macrophages, showed isointensity with peripheral hyperintense regions on T(1)WIs and hypointensity on both T(2)WIs and DWIs. The mean ADC value was 1.67 × 10(-3) mm(2) s(-1). After 2 weeks, the thrombi, which revealed RBC lysis surrounded by granulation tissues, showed isointensity on T(1)WIs and hyperintensity on T(2)WIs and DWIs. The mean ADC value was 2.48 × 10(-3) mm(2) s(-1).
The temporal MRI characteristics seemed to be related to chemical and physical changes in RBC and organisation of granulation tissues. Free radicals generated by macrophages might also be related to some extent. |
| doi_str_mv | 10.1259/bjr/37592039 |
| format | Article |
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Inferior vena cava thrombi were induced in 12 pigs. MRI was performed in three pigs 2 h, 1 day, 3 days and 2 weeks after thrombus induction.
The MRI characteristics were analysed in correlation with histopathological findings. The thrombi after 2 hours, which consisted of red blood cells (RBCs), showed isointensity on T(1 )weighted images (T(1)WIs) and hyperintensity on both T(2 )weighted images (T(2)WIs) and diffusion-weighted images (DWIs). The mean apparent diffusion coefficient (ADC) value was 1.93 × 10(-3) mm(2) s(-1). The thrombi after Day 1, which consisted of RBCs and migrating neutrophils at the periphery, showed isointensity on T(1)WIs, slight hyperintensity on T(2)WIs and hypointensity on DWIs. The mean ADC value was 1.62 × 10(-3) mm(2) s(-1) [corrected]. The thrombi after Day 3, which consisted of RBCs and peripheral inflammatory cells including macrophages, showed isointensity with peripheral hyperintense regions on T(1)WIs and hypointensity on both T(2)WIs and DWIs. The mean ADC value was 1.67 × 10(-3) mm(2) s(-1). After 2 weeks, the thrombi, which revealed RBC lysis surrounded by granulation tissues, showed isointensity on T(1)WIs and hyperintensity on T(2)WIs and DWIs. The mean ADC value was 2.48 × 10(-3) mm(2) s(-1).
The temporal MRI characteristics seemed to be related to chemical and physical changes in RBC and organisation of granulation tissues. Free radicals generated by macrophages might also be related to some extent.</description><identifier>ISSN: 0007-1285</identifier><identifier>EISSN: 1748-880X</identifier><identifier>DOI: 10.1259/bjr/37592039</identifier><identifier>PMID: 22457401</identifier><identifier>CODEN: BJRAAP</identifier><language>eng</language><publisher>London: British Institute of Radiology</publisher><subject>Animals ; Biological and medical sciences ; Diffusion Magnetic Resonance Imaging ; Erythrocytes - pathology ; Female ; Granulation Tissue - pathology ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Medical sciences ; Swine ; Time Factors ; Vena Cava, Inferior - pathology ; Venous Thrombosis - pathology</subject><ispartof>British journal of radiology, 2012-04, Vol.85 (1012), p.331-338</ispartof><rights>2015 INIST-CNRS</rights><rights>2012 The British Institute of Radiology 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-a4141e58887085f7e340d40c74cd5bb0622d137ccbe040c45fadbdc36a09546a3</citedby><cites>FETCH-LOGICAL-c413t-a4141e58887085f7e340d40c74cd5bb0622d137ccbe040c45fadbdc36a09546a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26037145$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22457401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ICHIKI, M</creatorcontrib><creatorcontrib>SAKAI, Y</creatorcontrib><creatorcontrib>MIKI, Y</creatorcontrib><creatorcontrib>NANGO, M</creatorcontrib><creatorcontrib>NAKAMURA, K</creatorcontrib><creatorcontrib>MATSUI, H</creatorcontrib><creatorcontrib>CHO, H</creatorcontrib><creatorcontrib>KITAYAMA, T</creatorcontrib><creatorcontrib>SAHARA, T</creatorcontrib><creatorcontrib>OTANI, N</creatorcontrib><creatorcontrib>INOUE, Y</creatorcontrib><title>Experimental venous thrombi: MRI characteristics with histopathological correlation</title><title>British journal of radiology</title><addtitle>Br J Radiol</addtitle><description>The purpose of this study was to evaluate the MRI characteristics of venous thrombus over set time thresholds with histopathological correlation in a porcine model.
Inferior vena cava thrombi were induced in 12 pigs. MRI was performed in three pigs 2 h, 1 day, 3 days and 2 weeks after thrombus induction.
The MRI characteristics were analysed in correlation with histopathological findings. The thrombi after 2 hours, which consisted of red blood cells (RBCs), showed isointensity on T(1 )weighted images (T(1)WIs) and hyperintensity on both T(2 )weighted images (T(2)WIs) and diffusion-weighted images (DWIs). The mean apparent diffusion coefficient (ADC) value was 1.93 × 10(-3) mm(2) s(-1). The thrombi after Day 1, which consisted of RBCs and migrating neutrophils at the periphery, showed isointensity on T(1)WIs, slight hyperintensity on T(2)WIs and hypointensity on DWIs. The mean ADC value was 1.62 × 10(-3) mm(2) s(-1) [corrected]. The thrombi after Day 3, which consisted of RBCs and peripheral inflammatory cells including macrophages, showed isointensity with peripheral hyperintense regions on T(1)WIs and hypointensity on both T(2)WIs and DWIs. The mean ADC value was 1.67 × 10(-3) mm(2) s(-1). After 2 weeks, the thrombi, which revealed RBC lysis surrounded by granulation tissues, showed isointensity on T(1)WIs and hyperintensity on T(2)WIs and DWIs. The mean ADC value was 2.48 × 10(-3) mm(2) s(-1).
The temporal MRI characteristics seemed to be related to chemical and physical changes in RBC and organisation of granulation tissues. Free radicals generated by macrophages might also be related to some extent.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Erythrocytes - pathology</subject><subject>Female</subject><subject>Granulation Tissue - pathology</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Swine</subject><subject>Time Factors</subject><subject>Vena Cava, Inferior - pathology</subject><subject>Venous Thrombosis - pathology</subject><issn>0007-1285</issn><issn>1748-880X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtPxCAUhYnR6PjYuTbdGDdWLwUKdWFizKiTaEx8JO4IpdRiOmUExse_F-P4WpELH-feew5C2xgOcMGqw_rJHxLOqgJItYRGmFORCwEPy2gEADzHhWBraD2Ep8-SVbCK1oqCMk4Bj9Dt-G1mvJ2aIao-ezGDm4csdt5Na3uUXd1MMt0pr3RMUIhWh-zVxi7rUuFmKnaud49Wp6_aeW96Fa0bNtFKq_pgthbnBro_G9-dXuSX1-eT05PLXFNMYq4optgwIQQHwVpuCIWGguZUN6yuoSyKBhOudW0gXVPWqqZuNCkVVIyWimyg4y_d2byemkanHbzq5Syto_y7dMrK_y-D7eSje5GEirJkZRLYWwh49zw3IcqpDdr0vRpM8kFWJaEVYEYTuf9Fau9C8Kb96YJBfsYgUwzyO4aE7_yd7Af-9j0BuwtAheRe69WgbfjlSiAcU0Y-AFZCkuM</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>ICHIKI, M</creator><creator>SAKAI, Y</creator><creator>MIKI, Y</creator><creator>NANGO, M</creator><creator>NAKAMURA, K</creator><creator>MATSUI, H</creator><creator>CHO, H</creator><creator>KITAYAMA, T</creator><creator>SAHARA, T</creator><creator>OTANI, N</creator><creator>INOUE, Y</creator><general>British Institute of Radiology</general><general>The British Institute of Radiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120401</creationdate><title>Experimental venous thrombi: MRI characteristics with histopathological correlation</title><author>ICHIKI, M ; SAKAI, Y ; MIKI, Y ; NANGO, M ; NAKAMURA, K ; MATSUI, H ; CHO, H ; KITAYAMA, T ; SAHARA, T ; OTANI, N ; INOUE, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-a4141e58887085f7e340d40c74cd5bb0622d137ccbe040c45fadbdc36a09546a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Erythrocytes - pathology</topic><topic>Female</topic><topic>Granulation Tissue - pathology</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Swine</topic><topic>Time Factors</topic><topic>Vena Cava, Inferior - pathology</topic><topic>Venous Thrombosis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ICHIKI, M</creatorcontrib><creatorcontrib>SAKAI, Y</creatorcontrib><creatorcontrib>MIKI, Y</creatorcontrib><creatorcontrib>NANGO, M</creatorcontrib><creatorcontrib>NAKAMURA, K</creatorcontrib><creatorcontrib>MATSUI, H</creatorcontrib><creatorcontrib>CHO, H</creatorcontrib><creatorcontrib>KITAYAMA, T</creatorcontrib><creatorcontrib>SAHARA, T</creatorcontrib><creatorcontrib>OTANI, N</creatorcontrib><creatorcontrib>INOUE, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ICHIKI, M</au><au>SAKAI, Y</au><au>MIKI, Y</au><au>NANGO, M</au><au>NAKAMURA, K</au><au>MATSUI, H</au><au>CHO, H</au><au>KITAYAMA, T</au><au>SAHARA, T</au><au>OTANI, N</au><au>INOUE, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental venous thrombi: MRI characteristics with histopathological correlation</atitle><jtitle>British journal of radiology</jtitle><addtitle>Br J Radiol</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>85</volume><issue>1012</issue><spage>331</spage><epage>338</epage><pages>331-338</pages><issn>0007-1285</issn><eissn>1748-880X</eissn><coden>BJRAAP</coden><abstract>The purpose of this study was to evaluate the MRI characteristics of venous thrombus over set time thresholds with histopathological correlation in a porcine model.
Inferior vena cava thrombi were induced in 12 pigs. MRI was performed in three pigs 2 h, 1 day, 3 days and 2 weeks after thrombus induction.
The MRI characteristics were analysed in correlation with histopathological findings. The thrombi after 2 hours, which consisted of red blood cells (RBCs), showed isointensity on T(1 )weighted images (T(1)WIs) and hyperintensity on both T(2 )weighted images (T(2)WIs) and diffusion-weighted images (DWIs). The mean apparent diffusion coefficient (ADC) value was 1.93 × 10(-3) mm(2) s(-1). The thrombi after Day 1, which consisted of RBCs and migrating neutrophils at the periphery, showed isointensity on T(1)WIs, slight hyperintensity on T(2)WIs and hypointensity on DWIs. The mean ADC value was 1.62 × 10(-3) mm(2) s(-1) [corrected]. The thrombi after Day 3, which consisted of RBCs and peripheral inflammatory cells including macrophages, showed isointensity with peripheral hyperintense regions on T(1)WIs and hypointensity on both T(2)WIs and DWIs. The mean ADC value was 1.67 × 10(-3) mm(2) s(-1). After 2 weeks, the thrombi, which revealed RBC lysis surrounded by granulation tissues, showed isointensity on T(1)WIs and hyperintensity on T(2)WIs and DWIs. The mean ADC value was 2.48 × 10(-3) mm(2) s(-1).
The temporal MRI characteristics seemed to be related to chemical and physical changes in RBC and organisation of granulation tissues. Free radicals generated by macrophages might also be related to some extent.</abstract><cop>London</cop><pub>British Institute of Radiology</pub><pmid>22457401</pmid><doi>10.1259/bjr/37592039</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of radiology, 2012-04, Vol.85 (1012), p.331-338 |
| issn | 0007-1285 1748-880X |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Biological and medical sciences Diffusion Magnetic Resonance Imaging Erythrocytes - pathology Female Granulation Tissue - pathology Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Medical sciences Swine Time Factors Vena Cava, Inferior - pathology Venous Thrombosis - pathology |
| title | Experimental venous thrombi: MRI characteristics with histopathological correlation |
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