Determinants of Bone Microarchitecture and Mechanical Properties in Obese Men
Context: Recent studies have suggested that obesity in men is associated with increased fracture risk. Obesity in men is also associated with dysregulation of the GH/IGF-I and gonadal steroid axes, important regulators of bone homeostasis. Objective: The aim of the study was to investigate body comp...
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| creator | Bredella, Miriam A Lin, Eleanor Gerweck, Anu V Landa, Melissa G Thomas, Bijoy J Torriani, Martin Bouxsein, Mary L Miller, Karen K |
| description | Context:
Recent studies have suggested that obesity in men is associated with increased fracture risk. Obesity in men is also associated with dysregulation of the GH/IGF-I and gonadal steroid axes, important regulators of bone homeostasis.
Objective:
The aim of the study was to investigate body composition and endocrine determinants of bone microarchitecture and mechanical properties in obese men.
Design and Setting:
We conducted a cross-sectional study at a clinical research center.
Participants:
Thirty-five obese men (mean age, 33.8 ± 6.4 yr; mean body mass index, 36.5 ± 5.8 kg/m2) participated in the study.
Outcome Measures:
Distal radius microarchitecture and mechanical properties were measured by three-dimensional high-resolution peripheral quantitative computed tomography and microfinite element analysis; body composition by computed tomography; bone marrow fat by proton magnetic resonance spectroscopy; total and free estradiol and testosterone; IGF-I; peak glucagon-stimulated GH; 25-hydroxyvitamin D.
Results:
Men with high visceral adipose tissue (VAT) had impaired mechanical properties compared to men with low VAT (P < 0.05), despite comparable body mass index. VAT was inversely associated and thigh muscle was positively associated with mechanical properties (P < 0.05). Bone marrow fat was inversely associated with cortical parameters (P ≤ 0.02). Free estradiol was positively associated with total density (P = 0.05). Free testosterone was positively associated with trabecular thickness and inversely with trabecular number (P ≤ 0.05). Peak stimulated GH was positively associated with trabecular thickness, as was IGF-I with cortical area (P ≤ 0.04).
Conclusion:
VAT and bone marrow fat are negative predictors and muscle mass is a positive predictor of microarchitecture and mechanical properties in obese men. Testosterone, estradiol, and GH are positive determinants of trabecular microarchitecture, and IGF-I is a positive determinant of cortical microarchitecture. This supports the notion that VAT is detrimental to bone and that decreased GH and testosterone, characteristic of male obesity, may exert deleterious effects on microarchitecture, whereas higher estradiol may be protective. |
| doi_str_mv | 10.1210/jc.2012-2246 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3485587</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1611620659</sourcerecordid><originalsourceid>FETCH-LOGICAL-c491t-c8b1274572faf3891106255caa63e3d0717f1064b7d2e71b9d70f2070eb296823</originalsourceid><addsrcrecordid>eNqFkc2LFDEQxYMo7rh68yx9ETzYa6qSdLovgq6fsMN6UPAW0ulqJ0NPMpt0C_73ZphxVRA8BSq_vHp5j7HHwC8Agb_YugvkgDWibO6wFXRS1Ro6fZetOEeoO41fz9iDnLecg5RK3GdniJ0QSvIVW7-hmdLOBxvmXMWxeh0DVWvvUrTJbfxMbl4SVTYM1Zrcxgbv7FR9SnFPafaUKx-q655yeUThIbs32inTo9N5zr68e_v58kN9df3-4-Wrq9rJDubatT2glkrjaEfRdgC8QaWctY0gMXANeiwj2esBSUPfDZqPyDWnHrumRXHOXh5190u_o8FRmJOdzD75nU0_TLTe_H0T_MZ8i9-NkK1SrS4Cz04CKd4slGez89nRNNlAcckGGoAGeaO6_6MgQZVcpSzo8yNa0ss50XjrCLg5lGW2zhzKMoeyCv7kz1_cwr_aKcDTE2BzSX1MNjiff3PFXovtwaI4chSG6JIPtE-Us9nGJYXSw7_X_wRkvKzS</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1141544544</pqid></control><display><type>article</type><title>Determinants of Bone Microarchitecture and Mechanical Properties in Obese Men</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Bredella, Miriam A ; Lin, Eleanor ; Gerweck, Anu V ; Landa, Melissa G ; Thomas, Bijoy J ; Torriani, Martin ; Bouxsein, Mary L ; Miller, Karen K</creator><creatorcontrib>Bredella, Miriam A ; Lin, Eleanor ; Gerweck, Anu V ; Landa, Melissa G ; Thomas, Bijoy J ; Torriani, Martin ; Bouxsein, Mary L ; Miller, Karen K</creatorcontrib><description>Context:
Recent studies have suggested that obesity in men is associated with increased fracture risk. Obesity in men is also associated with dysregulation of the GH/IGF-I and gonadal steroid axes, important regulators of bone homeostasis.
Objective:
The aim of the study was to investigate body composition and endocrine determinants of bone microarchitecture and mechanical properties in obese men.
Design and Setting:
We conducted a cross-sectional study at a clinical research center.
Participants:
Thirty-five obese men (mean age, 33.8 ± 6.4 yr; mean body mass index, 36.5 ± 5.8 kg/m2) participated in the study.
Outcome Measures:
Distal radius microarchitecture and mechanical properties were measured by three-dimensional high-resolution peripheral quantitative computed tomography and microfinite element analysis; body composition by computed tomography; bone marrow fat by proton magnetic resonance spectroscopy; total and free estradiol and testosterone; IGF-I; peak glucagon-stimulated GH; 25-hydroxyvitamin D.
Results:
Men with high visceral adipose tissue (VAT) had impaired mechanical properties compared to men with low VAT (P < 0.05), despite comparable body mass index. VAT was inversely associated and thigh muscle was positively associated with mechanical properties (P < 0.05). Bone marrow fat was inversely associated with cortical parameters (P ≤ 0.02). Free estradiol was positively associated with total density (P = 0.05). Free testosterone was positively associated with trabecular thickness and inversely with trabecular number (P ≤ 0.05). Peak stimulated GH was positively associated with trabecular thickness, as was IGF-I with cortical area (P ≤ 0.04).
Conclusion:
VAT and bone marrow fat are negative predictors and muscle mass is a positive predictor of microarchitecture and mechanical properties in obese men. Testosterone, estradiol, and GH are positive determinants of trabecular microarchitecture, and IGF-I is a positive determinant of cortical microarchitecture. This supports the notion that VAT is detrimental to bone and that decreased GH and testosterone, characteristic of male obesity, may exert deleterious effects on microarchitecture, whereas higher estradiol may be protective.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2012-2246</identifier><identifier>PMID: 22933540</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adipose Tissue - diagnostic imaging ; Adolescent ; Adult ; Biological and medical sciences ; Body Composition - physiology ; Body Mass Index ; Bone and Bones - diagnostic imaging ; Bone and Bones - physiopathology ; Bone Density - physiology ; Cross-Sectional Studies ; Endocrine Research ; Endocrinopathies ; Estradiol - blood ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Growth Hormone - blood ; Humans ; Insulin-Like Growth Factor I - metabolism ; Male ; Medical sciences ; Middle Aged ; Obesity - blood ; Obesity - diagnostic imaging ; Obesity - physiopathology ; Radiography ; Testosterone - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology ; Vitamin D - analogs & derivatives ; Vitamin D - blood</subject><ispartof>The journal of clinical endocrinology and metabolism, 2012-11, Vol.97 (11), p.4115-4122</ispartof><rights>Copyright © 2012 by The Endocrine Society</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 by The Endocrine Society 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-c8b1274572faf3891106255caa63e3d0717f1064b7d2e71b9d70f2070eb296823</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26598289$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22933540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bredella, Miriam A</creatorcontrib><creatorcontrib>Lin, Eleanor</creatorcontrib><creatorcontrib>Gerweck, Anu V</creatorcontrib><creatorcontrib>Landa, Melissa G</creatorcontrib><creatorcontrib>Thomas, Bijoy J</creatorcontrib><creatorcontrib>Torriani, Martin</creatorcontrib><creatorcontrib>Bouxsein, Mary L</creatorcontrib><creatorcontrib>Miller, Karen K</creatorcontrib><title>Determinants of Bone Microarchitecture and Mechanical Properties in Obese Men</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context:
Recent studies have suggested that obesity in men is associated with increased fracture risk. Obesity in men is also associated with dysregulation of the GH/IGF-I and gonadal steroid axes, important regulators of bone homeostasis.
Objective:
The aim of the study was to investigate body composition and endocrine determinants of bone microarchitecture and mechanical properties in obese men.
Design and Setting:
We conducted a cross-sectional study at a clinical research center.
Participants:
Thirty-five obese men (mean age, 33.8 ± 6.4 yr; mean body mass index, 36.5 ± 5.8 kg/m2) participated in the study.
Outcome Measures:
Distal radius microarchitecture and mechanical properties were measured by three-dimensional high-resolution peripheral quantitative computed tomography and microfinite element analysis; body composition by computed tomography; bone marrow fat by proton magnetic resonance spectroscopy; total and free estradiol and testosterone; IGF-I; peak glucagon-stimulated GH; 25-hydroxyvitamin D.
Results:
Men with high visceral adipose tissue (VAT) had impaired mechanical properties compared to men with low VAT (P < 0.05), despite comparable body mass index. VAT was inversely associated and thigh muscle was positively associated with mechanical properties (P < 0.05). Bone marrow fat was inversely associated with cortical parameters (P ≤ 0.02). Free estradiol was positively associated with total density (P = 0.05). Free testosterone was positively associated with trabecular thickness and inversely with trabecular number (P ≤ 0.05). Peak stimulated GH was positively associated with trabecular thickness, as was IGF-I with cortical area (P ≤ 0.04).
Conclusion:
VAT and bone marrow fat are negative predictors and muscle mass is a positive predictor of microarchitecture and mechanical properties in obese men. Testosterone, estradiol, and GH are positive determinants of trabecular microarchitecture, and IGF-I is a positive determinant of cortical microarchitecture. This supports the notion that VAT is detrimental to bone and that decreased GH and testosterone, characteristic of male obesity, may exert deleterious effects on microarchitecture, whereas higher estradiol may be protective.</description><subject>Adipose Tissue - diagnostic imaging</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body Composition - physiology</subject><subject>Body Mass Index</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone and Bones - physiopathology</subject><subject>Bone Density - physiology</subject><subject>Cross-Sectional Studies</subject><subject>Endocrine Research</subject><subject>Endocrinopathies</subject><subject>Estradiol - blood</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth Hormone - blood</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Obesity - blood</subject><subject>Obesity - diagnostic imaging</subject><subject>Obesity - physiopathology</subject><subject>Radiography</subject><subject>Testosterone - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2LFDEQxYMo7rh68yx9ETzYa6qSdLovgq6fsMN6UPAW0ulqJ0NPMpt0C_73ZphxVRA8BSq_vHp5j7HHwC8Agb_YugvkgDWibO6wFXRS1Ro6fZetOEeoO41fz9iDnLecg5RK3GdniJ0QSvIVW7-hmdLOBxvmXMWxeh0DVWvvUrTJbfxMbl4SVTYM1Zrcxgbv7FR9SnFPafaUKx-q655yeUThIbs32inTo9N5zr68e_v58kN9df3-4-Wrq9rJDubatT2glkrjaEfRdgC8QaWctY0gMXANeiwj2esBSUPfDZqPyDWnHrumRXHOXh5190u_o8FRmJOdzD75nU0_TLTe_H0T_MZ8i9-NkK1SrS4Cz04CKd4slGez89nRNNlAcckGGoAGeaO6_6MgQZVcpSzo8yNa0ss50XjrCLg5lGW2zhzKMoeyCv7kz1_cwr_aKcDTE2BzSX1MNjiff3PFXovtwaI4chSG6JIPtE-Us9nGJYXSw7_X_wRkvKzS</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Bredella, Miriam A</creator><creator>Lin, Eleanor</creator><creator>Gerweck, Anu V</creator><creator>Landa, Melissa G</creator><creator>Thomas, Bijoy J</creator><creator>Torriani, Martin</creator><creator>Bouxsein, Mary L</creator><creator>Miller, Karen K</creator><general>Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope><scope>7TS</scope><scope>5PM</scope></search><sort><creationdate>20121101</creationdate><title>Determinants of Bone Microarchitecture and Mechanical Properties in Obese Men</title><author>Bredella, Miriam A ; Lin, Eleanor ; Gerweck, Anu V ; Landa, Melissa G ; Thomas, Bijoy J ; Torriani, Martin ; Bouxsein, Mary L ; Miller, Karen K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-c8b1274572faf3891106255caa63e3d0717f1064b7d2e71b9d70f2070eb296823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adipose Tissue - diagnostic imaging</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body Composition - physiology</topic><topic>Body Mass Index</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone and Bones - physiopathology</topic><topic>Bone Density - physiology</topic><topic>Cross-Sectional Studies</topic><topic>Endocrine Research</topic><topic>Endocrinopathies</topic><topic>Estradiol - blood</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Growth Hormone - blood</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Obesity - blood</topic><topic>Obesity - diagnostic imaging</topic><topic>Obesity - physiopathology</topic><topic>Radiography</topic><topic>Testosterone - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bredella, Miriam A</creatorcontrib><creatorcontrib>Lin, Eleanor</creatorcontrib><creatorcontrib>Gerweck, Anu V</creatorcontrib><creatorcontrib>Landa, Melissa G</creatorcontrib><creatorcontrib>Thomas, Bijoy J</creatorcontrib><creatorcontrib>Torriani, Martin</creatorcontrib><creatorcontrib>Bouxsein, Mary L</creatorcontrib><creatorcontrib>Miller, Karen K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bredella, Miriam A</au><au>Lin, Eleanor</au><au>Gerweck, Anu V</au><au>Landa, Melissa G</au><au>Thomas, Bijoy J</au><au>Torriani, Martin</au><au>Bouxsein, Mary L</au><au>Miller, Karen K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determinants of Bone Microarchitecture and Mechanical Properties in Obese Men</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>97</volume><issue>11</issue><spage>4115</spage><epage>4122</epage><pages>4115-4122</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Context:
Recent studies have suggested that obesity in men is associated with increased fracture risk. Obesity in men is also associated with dysregulation of the GH/IGF-I and gonadal steroid axes, important regulators of bone homeostasis.
Objective:
The aim of the study was to investigate body composition and endocrine determinants of bone microarchitecture and mechanical properties in obese men.
Design and Setting:
We conducted a cross-sectional study at a clinical research center.
Participants:
Thirty-five obese men (mean age, 33.8 ± 6.4 yr; mean body mass index, 36.5 ± 5.8 kg/m2) participated in the study.
Outcome Measures:
Distal radius microarchitecture and mechanical properties were measured by three-dimensional high-resolution peripheral quantitative computed tomography and microfinite element analysis; body composition by computed tomography; bone marrow fat by proton magnetic resonance spectroscopy; total and free estradiol and testosterone; IGF-I; peak glucagon-stimulated GH; 25-hydroxyvitamin D.
Results:
Men with high visceral adipose tissue (VAT) had impaired mechanical properties compared to men with low VAT (P < 0.05), despite comparable body mass index. VAT was inversely associated and thigh muscle was positively associated with mechanical properties (P < 0.05). Bone marrow fat was inversely associated with cortical parameters (P ≤ 0.02). Free estradiol was positively associated with total density (P = 0.05). Free testosterone was positively associated with trabecular thickness and inversely with trabecular number (P ≤ 0.05). Peak stimulated GH was positively associated with trabecular thickness, as was IGF-I with cortical area (P ≤ 0.04).
Conclusion:
VAT and bone marrow fat are negative predictors and muscle mass is a positive predictor of microarchitecture and mechanical properties in obese men. Testosterone, estradiol, and GH are positive determinants of trabecular microarchitecture, and IGF-I is a positive determinant of cortical microarchitecture. This supports the notion that VAT is detrimental to bone and that decreased GH and testosterone, characteristic of male obesity, may exert deleterious effects on microarchitecture, whereas higher estradiol may be protective.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>22933540</pmid><doi>10.1210/jc.2012-2246</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2012-11, Vol.97 (11), p.4115-4122 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3485587 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adipose Tissue - diagnostic imaging Adolescent Adult Biological and medical sciences Body Composition - physiology Body Mass Index Bone and Bones - diagnostic imaging Bone and Bones - physiopathology Bone Density - physiology Cross-Sectional Studies Endocrine Research Endocrinopathies Estradiol - blood Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Growth Hormone - blood Humans Insulin-Like Growth Factor I - metabolism Male Medical sciences Middle Aged Obesity - blood Obesity - diagnostic imaging Obesity - physiopathology Radiography Testosterone - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology Vitamin D - analogs & derivatives Vitamin D - blood |
| title | Determinants of Bone Microarchitecture and Mechanical Properties in Obese Men |
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