Epithelium and Bowman's layer thickness and light scatter in keratoconic cornea evaluated using ultrahigh resolution optical coherence tomography
A custom-developed ultrahigh resolution optical coherence tomography with an axial resolution of 1.1 μm in corneal tissue was used to characterize thickness and light scatter of the epithelium and Bowman's layer in keratoconic (KC) cornea noninvasively. A 4-mm wide vertical corneal section arou...
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| Veröffentlicht in: | Journal of biomedical optics 2012-11, Vol.17 (11), p.116010-116010 |
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| container_issue | 11 |
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| container_title | Journal of biomedical optics |
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| creator | Yadav, Rahul Kottaiyan, Ranjini Ahmad, Kamran Yoon, Geunyoung |
| description | A custom-developed ultrahigh resolution optical coherence tomography with an axial resolution of 1.1 μm in corneal tissue was used to characterize thickness and light scatter of the epithelium and Bowman's layer in keratoconic (KC) cornea noninvasively. A 4-mm wide vertical corneal section around the apex in nine KC and eight normal eyes was imaged in vivo. The epithelium and Bowman's layer were visualized and their thickness profiles were quantified. Scatter was quantified based on the sensitivity normalized mean signal intensity distribution. Average mean thickness of the epithelium and Bowman's layer in KC eyes was significantly smaller (p |
| doi_str_mv | 10.1117/1.JBO.17.11.116010 |
| format | Article |
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A 4-mm wide vertical corneal section around the apex in nine KC and eight normal eyes was imaged in vivo. The epithelium and Bowman's layer were visualized and their thickness profiles were quantified. Scatter was quantified based on the sensitivity normalized mean signal intensity distribution. Average mean thickness of the epithelium and Bowman's layer in KC eyes was significantly smaller (p<0.05) than the normal eyes. The epithelium thickness variation across a central 3-mm cornea was significantly larger in KC eyes than in normal eyes. The scatter in KC eyes was significantly increased only for Bowman's layer. The changes observed in this study could improve our understanding of the underlying disease mechanism of KC and can provide new indications for early disease diagnosis.</description><identifier>ISSN: 1083-3668</identifier><identifier>EISSN: 1560-2281</identifier><identifier>DOI: 10.1117/1.JBO.17.11.116010</identifier><identifier>PMID: 23117805</identifier><language>eng</language><publisher>United States: Society of Photo-Optical Instrumentation Engineers</publisher><subject>Adult ; Bowman Membrane - pathology ; Case-Control Studies ; Diagnostic Techniques, Ophthalmological - statistics & numerical data ; Epithelium, Corneal - pathology ; Humans ; Image Processing, Computer-Assisted - statistics & numerical data ; Keratoconus - pathology ; Light ; Middle Aged ; Optical Phenomena ; Research Papers: Imaging ; Scattering, Radiation ; Tomography, Optical Coherence - methods ; Tomography, Optical Coherence - statistics & numerical data ; Young Adult</subject><ispartof>Journal of biomedical optics, 2012-11, Vol.17 (11), p.116010-116010</ispartof><rights>2012 Society of Photo-Optical Instrumentation Engineers (SPIE) 2012 Society of Photo-Optical Instrumentation Engineers</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-a998ea8ba77f39238fdd6b2a44c14a794c08a89567b59f32fbf8807f95660e583</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484266/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484266/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23117805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yadav, Rahul</creatorcontrib><creatorcontrib>Kottaiyan, Ranjini</creatorcontrib><creatorcontrib>Ahmad, Kamran</creatorcontrib><creatorcontrib>Yoon, Geunyoung</creatorcontrib><title>Epithelium and Bowman's layer thickness and light scatter in keratoconic cornea evaluated using ultrahigh resolution optical coherence tomography</title><title>Journal of biomedical optics</title><addtitle>J Biomed Opt</addtitle><description>A custom-developed ultrahigh resolution optical coherence tomography with an axial resolution of 1.1 μm in corneal tissue was used to characterize thickness and light scatter of the epithelium and Bowman's layer in keratoconic (KC) cornea noninvasively. A 4-mm wide vertical corneal section around the apex in nine KC and eight normal eyes was imaged in vivo. The epithelium and Bowman's layer were visualized and their thickness profiles were quantified. Scatter was quantified based on the sensitivity normalized mean signal intensity distribution. Average mean thickness of the epithelium and Bowman's layer in KC eyes was significantly smaller (p<0.05) than the normal eyes. The epithelium thickness variation across a central 3-mm cornea was significantly larger in KC eyes than in normal eyes. The scatter in KC eyes was significantly increased only for Bowman's layer. The changes observed in this study could improve our understanding of the underlying disease mechanism of KC and can provide new indications for early disease diagnosis.</description><subject>Adult</subject><subject>Bowman Membrane - pathology</subject><subject>Case-Control Studies</subject><subject>Diagnostic Techniques, Ophthalmological - statistics & numerical data</subject><subject>Epithelium, Corneal - pathology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - statistics & numerical data</subject><subject>Keratoconus - pathology</subject><subject>Light</subject><subject>Middle Aged</subject><subject>Optical Phenomena</subject><subject>Research Papers: Imaging</subject><subject>Scattering, Radiation</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Tomography, Optical Coherence - statistics & numerical data</subject><subject>Young Adult</subject><issn>1083-3668</issn><issn>1560-2281</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUctu1TAQjRAVffEDLJB3sMnFjhPH2SDRquWhSt20a2viTG5MHTvYTtH9DP4YX26pQBppZnweHukUxRtGN4yx9gPbfLu43bA2b7kEZfRFccIaQcuqkuxlnqnkJRdCHhenMX6nlErRiVfFccWzXtLmpPh1tZg0oTXrTMAN5ML_nMG9i8TCDgNJk9EPDmP8A1qznRKJGlLKmHHkAQMkr70zmmgfHALBR7ArJBzIGo3bktWmAFMWkoDR2zUZ74hfktFgs2bCgE4jSX722wDLtDsvjkawEV8_9bPi_vrq7vJLeXP7-evlp5tS80amErpOIsge2nbkXcXlOAyir6CuNauh7WpNJciuEW3fdCOvxn6UkrZjfhEUG8nPio8H32XtZxw0unyoVUswM4Sd8mDU_4gzk9r6R8VrWVdCZIP3TwbB_1gxJjWbqNFacOjXqBjLrIrzdk-tDlQdfIwBx-dvGFX7LBVTOUu1H5g6ZJlFb_898FnyNzz-G_Fen10</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Yadav, Rahul</creator><creator>Kottaiyan, Ranjini</creator><creator>Ahmad, Kamran</creator><creator>Yoon, Geunyoung</creator><general>Society of Photo-Optical Instrumentation Engineers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201211</creationdate><title>Epithelium and Bowman's layer thickness and light scatter in keratoconic cornea evaluated using ultrahigh resolution optical coherence tomography</title><author>Yadav, Rahul ; Kottaiyan, Ranjini ; Ahmad, Kamran ; Yoon, Geunyoung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-a998ea8ba77f39238fdd6b2a44c14a794c08a89567b59f32fbf8807f95660e583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Bowman Membrane - pathology</topic><topic>Case-Control Studies</topic><topic>Diagnostic Techniques, Ophthalmological - statistics & numerical data</topic><topic>Epithelium, Corneal - pathology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - statistics & numerical data</topic><topic>Keratoconus - pathology</topic><topic>Light</topic><topic>Middle Aged</topic><topic>Optical Phenomena</topic><topic>Research Papers: Imaging</topic><topic>Scattering, Radiation</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Tomography, Optical Coherence - statistics & numerical data</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yadav, Rahul</creatorcontrib><creatorcontrib>Kottaiyan, Ranjini</creatorcontrib><creatorcontrib>Ahmad, Kamran</creatorcontrib><creatorcontrib>Yoon, Geunyoung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of biomedical optics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yadav, Rahul</au><au>Kottaiyan, Ranjini</au><au>Ahmad, Kamran</au><au>Yoon, Geunyoung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epithelium and Bowman's layer thickness and light scatter in keratoconic cornea evaluated using ultrahigh resolution optical coherence tomography</atitle><jtitle>Journal of biomedical optics</jtitle><addtitle>J Biomed Opt</addtitle><date>2012-11</date><risdate>2012</risdate><volume>17</volume><issue>11</issue><spage>116010</spage><epage>116010</epage><pages>116010-116010</pages><issn>1083-3668</issn><eissn>1560-2281</eissn><abstract>A custom-developed ultrahigh resolution optical coherence tomography with an axial resolution of 1.1 μm in corneal tissue was used to characterize thickness and light scatter of the epithelium and Bowman's layer in keratoconic (KC) cornea noninvasively. A 4-mm wide vertical corneal section around the apex in nine KC and eight normal eyes was imaged in vivo. The epithelium and Bowman's layer were visualized and their thickness profiles were quantified. Scatter was quantified based on the sensitivity normalized mean signal intensity distribution. Average mean thickness of the epithelium and Bowman's layer in KC eyes was significantly smaller (p<0.05) than the normal eyes. The epithelium thickness variation across a central 3-mm cornea was significantly larger in KC eyes than in normal eyes. The scatter in KC eyes was significantly increased only for Bowman's layer. The changes observed in this study could improve our understanding of the underlying disease mechanism of KC and can provide new indications for early disease diagnosis.</abstract><cop>United States</cop><pub>Society of Photo-Optical Instrumentation Engineers</pub><pmid>23117805</pmid><doi>10.1117/1.JBO.17.11.116010</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Bowman Membrane - pathology Case-Control Studies Diagnostic Techniques, Ophthalmological - statistics & numerical data Epithelium, Corneal - pathology Humans Image Processing, Computer-Assisted - statistics & numerical data Keratoconus - pathology Light Middle Aged Optical Phenomena Research Papers: Imaging Scattering, Radiation Tomography, Optical Coherence - methods Tomography, Optical Coherence - statistics & numerical data Young Adult |
| title | Epithelium and Bowman's layer thickness and light scatter in keratoconic cornea evaluated using ultrahigh resolution optical coherence tomography |
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