Genome-wide Measurement of RNA Folding Energies

RNA structural transitions are important in the function and regulation of RNAs. Here, we reveal a layer of transcriptome organization in the form of RNA folding energies. By probing yeast RNA structures at different temperatures, we obtained relative melting temperatures (Tm) for RNA structures in...

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Veröffentlicht in:	Molecular cell 2012-10, Vol.48 (2), p.169-181
Hauptverfasser:	Wan, Yue, Qu, Kun, Ouyang, Zhengqing, Kertesz, Michael, Li, Jun, Tibshirani, Robert, Makino, Debora L., Nutter, Robert C., Segal, Eran, Chang, Howard Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Computational Biology Energy Metabolism Exosome Multienzyme Ribonuclease Complex - chemistry Exosome Multienzyme Ribonuclease Complex - genetics exosomes Gene Expression Profiling genes Genome heat melting messenger RNA Molecular Sequence Data Nucleic Acid Conformation nucleotide motifs Nucleotide Motifs - genetics open reading frames RNA - chemistry RNA - genetics RNA Folding Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Temperature thermometers transcriptome yeasts
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