A novel function for platelet-derived growth factor D: induction of osteoclastic differentiation for intraosseous tumor growth

Although increasing evidence suggests a critical role for platelet-derived growth factor (PDGF) receptor β (β-PDGFR) signaling in prostate cancer (PCa) progression, the precise roles of β-PDGFR and PDGF isoform-specific cell signaling have not been delineated. Recently, we identified the PDGF-D isof...

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Veröffentlicht in:	Oncogene 2012-10, Vol.31 (42), p.4527-4535
Hauptverfasser:	Huang, W, Fridman, Y, Bonfil, R D, Ustach, C V, Conley-LaComb, M K, Wiesner, C, Saliganan, A, Cher, M L, Kim, H-R C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/322/803 631/80/86 692/698/690/797 692/699/67/589/466 Acid Phosphatase - genetics Acid Phosphatase - metabolism Animals Apoptosis Blotting, Western Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Bones Care and treatment Cell Biology Cell differentiation Cell Differentiation - drug effects Cell Line Cell Line, Tumor Development and progression Gene expression Genetic aspects Human Genetics Humans Immunohistochemistry Internal Medicine Isoenzymes - genetics Isoenzymes - metabolism Lymphokines - genetics Lymphokines - metabolism Lymphokines - pharmacology Male Medicine Medicine & Public Health Metastasis Mice Mice, SCID Mutation NIH 3T3 Cells Oncology Original original-article Osteoclasts (Biology) Osteoclasts - drug effects Osteoclasts - metabolism Physiological aspects Platelet-derived growth factor Platelet-Derived Growth Factor - genetics Platelet-Derived Growth Factor - metabolism Platelet-Derived Growth Factor - pharmacology Prostate cancer Proteins Proto-Oncogene Proteins c-sis - metabolism Proto-Oncogene Proteins c-sis - pharmacology RANK Ligand - genetics RANK Ligand - pharmacology Receptor, Platelet-Derived Growth Factor beta - genetics Receptor, Platelet-Derived Growth Factor beta - metabolism Recombinant Proteins - pharmacology Reverse Transcriptase Polymerase Chain Reaction Tartrate-Resistant Acid Phosphatase Tibia - drug effects Tibia - metabolism Tibia - pathology
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