The axon initial segment in nervous system disease and injury

The axon initial segment (AIS), with its dense clusters of voltage‐gated ion channels decorating the axonal membrane, regulates action potential initiation and modulation. The AIS also functions as a barrier to maintain axodendritic polarity, and its precise axonal location contributes to the fine‐t...

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Veröffentlicht in:	The European journal of neuroscience 2011-11, Vol.34 (10), p.1609-1619
Hauptverfasser:	Buffington, Shelly A., Rasband, Matthew N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Action Potentials - physiology Aging - physiology Animals Ankyrins - metabolism axon initial segment Axons Axons - physiology Axons - ultrastructure Cell Polarity disease Excitability Humans Injuries ion channel Ion channels Ion Channels - metabolism Mental Disorders - pathology Mental Disorders - physiopathology Mutation Nervous system Nervous System - pathology Nervous System - physiopathology Nervous system diseases Nervous System Diseases - pathology Nervous System Diseases - physiopathology Neurological diseases Neuronal Plasticity - physiology Neurons - physiology Neurons - ultrastructure Polarity
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