Ceramide Glycosylation by Glucosylceramide Synthase Selectively Maintains the Properties of Breast Cancer Stem Cells

Cancer stem cells are distinguished from normal adult stem cells by their stemness without tissue homeostasis control. Glycosphingolipids (GSLs), particularly globo-series GSLs, are important markers of undifferentiated embryonic stem cells, but little is known about whether or not ceramide glycosyl...

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Veröffentlicht in:	The Journal of biological chemistry 2012-10, Vol.287 (44), p.37195-37205
Hauptverfasser:	Gupta, Vineet, Bhinge, Kaustubh N., Hosain, Salman B., Xiong, Katherine, Gu, Xin, Shi, Runhua, Ho, Ming-Yi, Khoo, Kay-Hooi, Li, Su-Chen, Li, Yu-Teh, Ambudkar, Suresh V., Jazwinski, S.Michal, Liu, Yong-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - pharmacology beta Catenin - metabolism Breast Neoplasms - enzymology Breast Neoplasms - pathology Cancer Catenin CD24 Antigen - metabolism Cell Biology Cell Separation Cell Survival - drug effects Cell Transformation, Neoplastic Ceramides - metabolism Doxorubicin - pharmacology Drug Resistance, Neoplasm Female Glucosylceramide Synthase Glucosyltransferases - metabolism Glycerosphingolipid Glycosylation Humans Hyaluronan Receptors - metabolism Immunomagnetic Separation MCF-7 Cells Mice Mice, Nude Neoplasm Transplantation Neoplastic Stem Cells - enzymology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Protein Processing, Post-Translational Signal Transduction Spheroids, Cellular - drug effects Src Stem Cells
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