Wnt5a Controls Notch1 Signaling through CaMKII-mediated Degradation of the SMRT Corepressor Protein

Serine-threonine Ca2+/calmodulin-dependent protein kinase II (CaMKII) is the key component in noncanonical Wnt5a signaling and has been shown to regulate its signaling. In this study, we found that CaMKII induced by Wnt5a remarkably reduced the protein stability of the silencing mediator of retinoic...

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Veröffentlicht in:	The Journal of biological chemistry 2012-10, Vol.287 (44), p.36814-36829
Hauptverfasser:	Ann, Eun-Jung, Kim, Hwa-Young, Seo, Mi-Sun, Mo, Jung-Soon, Kim, Mi-Yeon, Yoon, Ji-Hye, Ahn, Ji-Seon, Park, Hee-Sae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism CaMKII Corepressor Transcription Down-Regulation Genes, Reporter HEK293 Cells Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism Luciferases - biosynthesis Luciferases - genetics Mice Notch Nuclear Receptor Co-Repressor 2 - metabolism Phosphorylation Promoter Regions, Genetic Proteasome Protein Binding Protein Processing, Post-Translational Protein Structure, Tertiary Protein Synthesis and Degradation Proteolysis Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins - physiology Receptor, Notch1 - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Transcription Factor HES-1 Transcriptional Activation Ubiquitination Wnt Proteins - metabolism Wnt Proteins - physiology Wnt Signaling Wnt Signaling Pathway Wnt-5a Protein
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