Lactic Acid Is Elevated in Idiopathic Pulmonary Fibrosis and Induces Myofibroblast Differentiation via pH-Dependent Activation of Transforming Growth Factor-β

Idiopathic pulmonary fibrosis (IPF) is a complex disease for which the pathogenesis is poorly understood. In this study, we identified lactic acid as a metabolite that is elevated in the lung tissue of patients with IPF. This study examines the effect of lactic acid on myofibroblast differentiation...

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Veröffentlicht in:	American Journal of Respiratory and Critical Care Medicine, 186(8):740-751 186(8):740-751, 2012-10, Vol.186 (8), p.740-751
Hauptverfasser:	KOTTMANN, Robert Matthew, KULKARNI, Ajit A, NATHAN, Steven D, GRANT, Geraldine, PHIPPS, Richard P, SIME, Patricia J, SMOLNYCKI, Katie A, LYDA, Elizabeth, DAHANAYAKE, Thinesh, SALIBI, Rami, HONNONS, Sylvie, JONES, Carolyn, ISERN, Nancy G, HU, Jian Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Case-Control Studies Cell Differentiation Environmental Molecular Sciences Laboratory Gene Expression Regulation, Enzymologic Humans Hydrogen-Ion Concentration Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Idiopathic Pulmonary Fibrosis - metabolism Idiopathic Pulmonary Fibrosis - physiopathology In Vitro Techniques Intensive care medicine Isoenzymes - metabolism L-Lactate Dehydrogenase - metabolism Lactic Acid - metabolism Magnetic Resonance Spectroscopy Medical sciences Myofibroblasts - metabolism Pneumology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Transforming Growth Factor beta - metabolism Up-Regulation
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