Reelin Controls Neuronal Positioning by Promoting Cell-Matrix Adhesion via Inside-Out Activation of Integrin α5β1

Birthdate-dependent neuronal layering is fundamental to neocortical functions. The extracellular protein Reelin is essential for the establishment of the eventual neuronal alignments. Although this Reelin-dependent neuronal layering is mainly established by the final neuronal migration step called “...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2012-10, Vol.76 (2), p.353-369
Hauptverfasser:	Sekine, Katsutoshi, Kawauchi, Takeshi, Kubo, Ken-ichiro, Honda, Takao, Herz, Joachim, Hattori, Mitsuharu, Kinashi, Tatsuo, Nakajima, Kazunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Analysis of Variance Animals Cell Adhesion - drug effects Cell Adhesion - genetics Cell Adhesion - physiology Cell Adhesion Molecules, Neuronal - drug effects Cell Adhesion Molecules, Neuronal - genetics Cell Adhesion Molecules, Neuronal - metabolism Cell Line, Transformed Cell Movement - drug effects Cell Movement - genetics Cell Movement - physiology Electroporation Embryo, Mammalian Extracellular Matrix Proteins - drug effects Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Female Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Gene Expression Regulation - physiology Green Fluorescent Proteins - genetics Humans Integrin alpha5beta1 - genetics Integrin alpha5beta1 - metabolism Mice Mice, Inbred ICR Mice, Neurologic Mutants Mice, Transgenic Mutation - genetics Nerve Tissue Proteins - drug effects Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons - drug effects Neurons - physiology Nuclear Proteins Pregnancy Proto-Oncogene Proteins c-crk - metabolism rap1 GTP-Binding Proteins - metabolism Serine Endopeptidases - drug effects Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Signal Transduction - genetics Signal Transduction - physiology Somatosensory Cortex - cytology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!