Alterations in Lipid Signaling Underlie Lipodystrophy Secondary to AGPAT2 Mutations

Congenital generalized lipodystrophy (CGL), secondary to AGPAT2 mutation is characterized by the absence of adipocytes and development of severe insulin resistance. In the current study, we investigated the adipogenic defect associated with AGPAT2 mutations. Adipogenesis was studied in muscle-derive...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2012-11, Vol.61 (11), p.2922-2931
Hauptverfasser:	SUBAUSTE, Angela R, DAS, Arun K, XIANGQUAN LI, ELLIOT, Brandon, EVANS, Charles, EL AZZOUNY, Mahmoud, TREUTELAAR, Mary, ORAL, Elif, LEFF, Todd, BURANT, Charles F
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Acids Acyltransferases - antagonists & inhibitors Acyltransferases - genetics Acyltransferases - metabolism Adipocytes Adipocytes - metabolism Adipocytes - pathology Adipogenesis Adipose tissue Adipose tissues Analysis Animals Antibiotics Biological and medical sciences Biopsy Body fat Cell death Cells, Cultured Dermatology Development and progression Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Flow cytometry Fourier transforms Genetic aspects Humans Kinases Lipid Metabolism Lipodystrophy Lipodystrophy, Congenital Generalized - genetics Lipodystrophy, Congenital Generalized - metabolism Lipodystrophy, Congenital Generalized - pathology Mass spectrometry Medical sciences Mice Multipotent Stem Cells - metabolism Multipotent Stem Cells - pathology Mutant Proteins - antagonists & inhibitors Mutant Proteins - genetics Mutant Proteins - metabolism Mutation Pathophysiology Phosphatidylinositol 3-Kinase - genetics Phosphatidylinositol 3-Kinase - metabolism Physiological aspects PPAR gamma - agonists PPAR gamma - antagonists & inhibitors PPAR gamma - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Quadriceps Muscle - metabolism Quadriceps Muscle - pathology Recombinant Fusion Proteins - antagonists & inhibitors Recombinant Fusion Proteins - metabolism RNA Interference RNA, Small Interfering Scientific imaging Signal Transduction Skin involvement in other diseases. Miscellaneous. General aspects
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