Neurofibromatosis type 1: modeling CNS dysfunction

Neurofibromatosis type 1 (NF1) is the most common monogenic disorder in which individuals manifest CNS abnormalities. Affected individuals develop glial neoplasms (optic gliomas, malignant astrocytomas) and neuronal dysfunction (learning disabilities, attention deficits). Nf1 genetically engineered...

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Veröffentlicht in:	The Journal of neuroscience 2012-10, Vol.32 (41), p.14087-14093
Hauptverfasser:	Gutmann, David H, Parada, Luis F, Silva, Alcino J, Ratner, Nancy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Central Nervous System Diseases - genetics Central Nervous System Diseases - metabolism Central Nervous System Diseases - physiopathology Disease Models, Animal Humans Neurofibromatosis 1 - genetics Neurofibromatosis 1 - metabolism Neurofibromatosis 1 - physiopathology Neurofibromin 1 - genetics Neurofibromin 1 - physiology Signal Transduction - physiology Symposium and Mini-Symposium
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