Combined inhibition of p38 and Akt signaling pathways abrogates cyclosporine A-mediated pathogenesis of aggressive skin SCCs

[Display omitted] ► p38 and Akt are the crucial molecular targets in the pathogenesis of SCCs in OTRs. ► Combined inhibition of these targets diminished tumor growth by 90%. ► Inhibition of these targets act through downregulating mTOR signaling pathway. Non-melanoma skin cancers (NMSCs) are the mos...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 2012-08, Vol.425 (2), p.177-181
Hauptverfasser:	Arumugam, Aadithya, Walsh, Stephanie B., Xu, Jianmin, Afaq, Farrukh, Elmets, Craig A., Athar, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Akt Animals APOPTOSIS Carcinoma, Squamous Cell - chemically induced Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - enzymology CYCLOSPORINE Cyclosporine - adverse effects Cyclosporine A Female GROWTH FACTORS Humans Immunosuppressive Agents - adverse effects INHIBITION LABELLING MAP Kinase Signaling System - drug effects MELANOMAS METASTASES Mice Mice, Nude MITOCHONDRIA Molecular Targeted Therapy mTOR Organ Transplantation - adverse effects OTR p38 p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors PATHOGENESIS PERMEABILITY PHENOTYPE PHOSPHOTRANSFERASES Proto-Oncogene Proteins c-akt - antagonists & inhibitors SCC SKIN Skin Neoplasms - chemically induced Skin Neoplasms - drug therapy Skin Neoplasms - enzymology TRANSPLANTS ULTRAVIOLET RADIATION
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!