The Endoplasmic Reticulum Stress Transducer BBF2H7 Suppresses Apoptosis by Activating the ATF5-MCL1 Pathway in Growth Plate Cartilage

BBF2H7 (box B-binding factor 2 human homolog on chromosome 7) is a basic leucine zipper transmembrane transcription factor that belongs to the cyclic AMP-responsive element-binding protein (CREB)/activating transcription factor (ATF) family. This novel endoplasmic reticulum (ER) stress transducer is...

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Veröffentlicht in:	The Journal of biological chemistry 2012-10, Vol.287 (43), p.36190-36200
Hauptverfasser:	Izumi, Soutarou, Saito, Atsushi, Kanemoto, Soshi, Kawasaki, Noritaka, Asada, Rie, Iwamoto, Hideo, Oki, Mami, Miyagi, Hidetaka, Ochi, Mitsuo, Imaizumi, Kazunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factors - genetics Activating Transcription Factors - metabolism Animals Apoptosis Apoptosis - physiology ATF5 Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism BBF2H7 Cartilage Cartilage - cytology Cartilage - metabolism Cell Biology Cell Proliferation Chondrocytes Chondrocytes - cytology Chondrocytes - metabolism Endoplasmic Reticulum Stress - physiology ER stress Growth Plate - cytology Growth Plate - metabolism Humans MCL1 Mice Mice, Knockout Myeloid Cell Leukemia Sequence 1 Protein Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Signal Transduction - physiology Transcription Vesicular Transport Proteins - genetics Vesicular Transport Proteins - metabolism
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