Primary oral melanoma: a histopathological and immunohistochemical study of 22 cases of Latin America
The aim of this study was to analyze the histopathological and immunohistochemical characteristics of 22 cases of primary oral melanomas (OM). Twenty two cases of primary oral melanoma were analyzed by description of their histopathological features and immunohistochemical study using the antibodies...
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| Veröffentlicht in: | Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2012-05, Vol.17 (3), p.e383-e388 |
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| creator | de-Andrade, Bruno-Augusto-Benevenuto Toral-Rizo, Víctor-Hugo León, Jorge-Esquiche Contreras, Elisa Carlos, Román Delgado-Azañero, Wilson Mosqueda-Taylor, Adalberto de-Almeida, Oslei-Paes |
| description | The aim of this study was to analyze the histopathological and immunohistochemical characteristics of 22 cases of primary oral melanomas (OM).
Twenty two cases of primary oral melanoma were analyzed by description of their histopathological features and immunohistochemical study using the antibodies S-100, HMB-45, Melan-A and Ki-67.
The mean age was 58 years and 14 cases were female. The main affected sites were the hard palate, followed by the upper gingiva. Microscopically, 15 cases presented level III of invasion, 2 cases were amelanotic and 13 showed a mixed epithelioid and plasmacytoid or spindle cells composition. Some cases showed necrosis, perivascular and perineural invasion. S-100 and HMB-45 were positive in all cases, but 3 cases were negative for Melan-A. The proliferative index with Ki-67 was high, with labeling index ranging from 15.51% to 63% of positive cells.
S-100 and HMB-45 are more frequently expressed than Melan-A in primary oral melanomas and these markers are helpful to confirm the diagnosis. |
| doi_str_mv | 10.4317/medoral.17588 |
| format | Article |
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Twenty two cases of primary oral melanoma were analyzed by description of their histopathological features and immunohistochemical study using the antibodies S-100, HMB-45, Melan-A and Ki-67.
The mean age was 58 years and 14 cases were female. The main affected sites were the hard palate, followed by the upper gingiva. Microscopically, 15 cases presented level III of invasion, 2 cases were amelanotic and 13 showed a mixed epithelioid and plasmacytoid or spindle cells composition. Some cases showed necrosis, perivascular and perineural invasion. S-100 and HMB-45 were positive in all cases, but 3 cases were negative for Melan-A. The proliferative index with Ki-67 was high, with labeling index ranging from 15.51% to 63% of positive cells.
S-100 and HMB-45 are more frequently expressed than Melan-A in primary oral melanomas and these markers are helpful to confirm the diagnosis.</description><identifier>ISSN: 1698-6946</identifier><identifier>ISSN: 1698-4447</identifier><identifier>EISSN: 1698-6946</identifier><identifier>DOI: 10.4317/medoral.17588</identifier><identifier>PMID: 22143732</identifier><language>eng</language><publisher>Spain: Medicina Oral S.L</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Dentistry ; Female ; Humans ; Immunohistochemistry ; Ki-67 Antigen - analysis ; Latin America ; Male ; MART-1 Antigen - analysis ; Melanoma - chemistry ; Melanoma - pathology ; Melanoma-Specific Antigens - analysis ; Middle Aged ; Mouth Neoplasms - chemistry ; Mouth Neoplasms - pathology ; Oral Medicine and Pathology ; S100 Proteins - analysis ; Young Adult</subject><ispartof>Medicina oral, patología oral y cirugía bucal, 2012-05, Vol.17 (3), p.e383-e388</ispartof><rights>Copyright: © 2012 Medicina Oral S.L. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-c3ca8389554f31b5408406d3fa8077e9dc3add4df650909f76c3d6242611dd613</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476096/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476096/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22143732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de-Andrade, Bruno-Augusto-Benevenuto</creatorcontrib><creatorcontrib>Toral-Rizo, Víctor-Hugo</creatorcontrib><creatorcontrib>León, Jorge-Esquiche</creatorcontrib><creatorcontrib>Contreras, Elisa</creatorcontrib><creatorcontrib>Carlos, Román</creatorcontrib><creatorcontrib>Delgado-Azañero, Wilson</creatorcontrib><creatorcontrib>Mosqueda-Taylor, Adalberto</creatorcontrib><creatorcontrib>de-Almeida, Oslei-Paes</creatorcontrib><title>Primary oral melanoma: a histopathological and immunohistochemical study of 22 cases of Latin America</title><title>Medicina oral, patología oral y cirugía bucal</title><addtitle>Med Oral Patol Oral Cir Bucal</addtitle><description>The aim of this study was to analyze the histopathological and immunohistochemical characteristics of 22 cases of primary oral melanomas (OM).
Twenty two cases of primary oral melanoma were analyzed by description of their histopathological features and immunohistochemical study using the antibodies S-100, HMB-45, Melan-A and Ki-67.
The mean age was 58 years and 14 cases were female. The main affected sites were the hard palate, followed by the upper gingiva. Microscopically, 15 cases presented level III of invasion, 2 cases were amelanotic and 13 showed a mixed epithelioid and plasmacytoid or spindle cells composition. Some cases showed necrosis, perivascular and perineural invasion. S-100 and HMB-45 were positive in all cases, but 3 cases were negative for Melan-A. The proliferative index with Ki-67 was high, with labeling index ranging from 15.51% to 63% of positive cells.
S-100 and HMB-45 are more frequently expressed than Melan-A in primary oral melanomas and these markers are helpful to confirm the diagnosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Dentistry</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ki-67 Antigen - analysis</subject><subject>Latin America</subject><subject>Male</subject><subject>MART-1 Antigen - analysis</subject><subject>Melanoma - chemistry</subject><subject>Melanoma - pathology</subject><subject>Melanoma-Specific Antigens - analysis</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - chemistry</subject><subject>Mouth Neoplasms - pathology</subject><subject>Oral Medicine and Pathology</subject><subject>S100 Proteins - analysis</subject><subject>Young Adult</subject><issn>1698-6946</issn><issn>1698-4447</issn><issn>1698-6946</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1PAyEUJEZja_Xo1XD0shUWFlgPJqbxK2miBz0TCmyLWZa67Jr472Xb2tTLey_MZB5vBoBLjKaUYH7jrQmtqqeYF0IcgTFmpchYSdnxwTwCZzF-IkQ45uwUjPIcU8JJPgb2rXVetT9wEIHe1qoJXt1CBVcudmGtulWow9LphKrGQOd934QNplfWb95j15skUME8h1pFG4d5rjrXwHtv28Q5ByeVqqO92PUJ-Hh8eJ89Z_PXp5fZ_TzTRPAuVa0EEWVR0IrgRUGRoIgZUimBOLel0UQZQ03FClSisuJME8NymjOMjWGYTMDdVnfdL5Ix2jZdOkuutzfKoJz8jzRuJZfhWxLKGSpZErjeCbThq7exk95Fbetkiw19lBhhnJymeKBmW6puQ4ytrfZrMJJDNHIXjdxEk_hXh3_bs_-yIL9S8I0x</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>de-Andrade, Bruno-Augusto-Benevenuto</creator><creator>Toral-Rizo, Víctor-Hugo</creator><creator>León, Jorge-Esquiche</creator><creator>Contreras, Elisa</creator><creator>Carlos, Román</creator><creator>Delgado-Azañero, Wilson</creator><creator>Mosqueda-Taylor, Adalberto</creator><creator>de-Almeida, Oslei-Paes</creator><general>Medicina Oral S.L</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120501</creationdate><title>Primary oral melanoma: a histopathological and immunohistochemical study of 22 cases of Latin America</title><author>de-Andrade, Bruno-Augusto-Benevenuto ; Toral-Rizo, Víctor-Hugo ; León, Jorge-Esquiche ; Contreras, Elisa ; Carlos, Román ; Delgado-Azañero, Wilson ; Mosqueda-Taylor, Adalberto ; de-Almeida, Oslei-Paes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-c3ca8389554f31b5408406d3fa8077e9dc3add4df650909f76c3d6242611dd613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Dentistry</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ki-67 Antigen - analysis</topic><topic>Latin America</topic><topic>Male</topic><topic>MART-1 Antigen - analysis</topic><topic>Melanoma - chemistry</topic><topic>Melanoma - pathology</topic><topic>Melanoma-Specific Antigens - analysis</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - chemistry</topic><topic>Mouth Neoplasms - pathology</topic><topic>Oral Medicine and Pathology</topic><topic>S100 Proteins - analysis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de-Andrade, Bruno-Augusto-Benevenuto</creatorcontrib><creatorcontrib>Toral-Rizo, Víctor-Hugo</creatorcontrib><creatorcontrib>León, Jorge-Esquiche</creatorcontrib><creatorcontrib>Contreras, Elisa</creatorcontrib><creatorcontrib>Carlos, Román</creatorcontrib><creatorcontrib>Delgado-Azañero, Wilson</creatorcontrib><creatorcontrib>Mosqueda-Taylor, Adalberto</creatorcontrib><creatorcontrib>de-Almeida, Oslei-Paes</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicina oral, patología oral y cirugía bucal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de-Andrade, Bruno-Augusto-Benevenuto</au><au>Toral-Rizo, Víctor-Hugo</au><au>León, Jorge-Esquiche</au><au>Contreras, Elisa</au><au>Carlos, Román</au><au>Delgado-Azañero, Wilson</au><au>Mosqueda-Taylor, Adalberto</au><au>de-Almeida, Oslei-Paes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary oral melanoma: a histopathological and immunohistochemical study of 22 cases of Latin America</atitle><jtitle>Medicina oral, patología oral y cirugía bucal</jtitle><addtitle>Med Oral Patol Oral Cir Bucal</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>17</volume><issue>3</issue><spage>e383</spage><epage>e388</epage><pages>e383-e388</pages><issn>1698-6946</issn><issn>1698-4447</issn><eissn>1698-6946</eissn><abstract>The aim of this study was to analyze the histopathological and immunohistochemical characteristics of 22 cases of primary oral melanomas (OM).
Twenty two cases of primary oral melanoma were analyzed by description of their histopathological features and immunohistochemical study using the antibodies S-100, HMB-45, Melan-A and Ki-67.
The mean age was 58 years and 14 cases were female. The main affected sites were the hard palate, followed by the upper gingiva. Microscopically, 15 cases presented level III of invasion, 2 cases were amelanotic and 13 showed a mixed epithelioid and plasmacytoid or spindle cells composition. Some cases showed necrosis, perivascular and perineural invasion. S-100 and HMB-45 were positive in all cases, but 3 cases were negative for Melan-A. The proliferative index with Ki-67 was high, with labeling index ranging from 15.51% to 63% of positive cells.
S-100 and HMB-45 are more frequently expressed than Melan-A in primary oral melanomas and these markers are helpful to confirm the diagnosis.</abstract><cop>Spain</cop><pub>Medicina Oral S.L</pub><pmid>22143732</pmid><doi>10.4317/medoral.17588</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Dentistry Female Humans Immunohistochemistry Ki-67 Antigen - analysis Latin America Male MART-1 Antigen - analysis Melanoma - chemistry Melanoma - pathology Melanoma-Specific Antigens - analysis Middle Aged Mouth Neoplasms - chemistry Mouth Neoplasms - pathology Oral Medicine and Pathology S100 Proteins - analysis Young Adult |
| title | Primary oral melanoma: a histopathological and immunohistochemical study of 22 cases of Latin America |
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