CYP1A1 and CYP1B1 gene expression and DNA adduct formation in normal human mammary epithelial cells exposed to benzo[a]pyrene in the absence or presence of chlorophyllin

Abstract Benzo[a]pyrene (BP) is a potent pro-carcinogen and ubiquitous environmental pollutant. Here, we examined the induction and modulation of CYP1A1 and CYP1B1 and 10-(deoxyguanosin-N2 -yl)-7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPdG) adduct formation in DNA from 20 primary normal h...

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Veröffentlicht in:	Cancer letters 2010-06, Vol.292 (2), p.254-260
Hauptverfasser:	John, Kaarthik, Divi, Rao L, Keshava, Channa, Orozco, Christine C, Schockley, Marie E, Richardson, Diana L, Poirier, Miriam C, Nath, Joginder, Weston, Ainsley
Format:	Artikel
Sprache:	eng
Schlagworte:	Aryl Hydrocarbon Hydroxylases - genetics Benzo(a)pyrene - pharmacology BPDE-DNA chemiluminescence immunoassay Cancer Carcinogens Cell cycle Chemoprevention Chlorophyllides - pharmacology Chlorophyllin Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1B1 Deoxyribonucleic acid DNA DNA Adducts Enzymes Gene expression Hematology, Oncology and Palliative Medicine Humans Mammary Glands, Human - cytology Mammary Glands, Human - drug effects Mammary Glands, Human - enzymology Medical research Occupational safety Polycyclic aromatic hydrocarbons Real-time-PCR Reverse Transcriptase Polymerase Chain Reaction Rodents
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