2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and Its Hydroxylated Metabolites Are Enantiomerically Enriched in Female Mice
Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral and undergo enantiomeric enrichment in mammalian species, which may modulate PCB developmental neurotoxicity. This study mea...
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| Veröffentlicht in: | Environmental science & technology 2012-10, Vol.46 (20), p.11393-11401 |
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| creator | Kania-Korwel, Izabela Barnhart, Christopher D Stamou, Marianna Truong, Kim M El-Komy, Mohammed H. M. E Lein, Pamela J Veng-Pedersen, Peter Lehmler, Hans-Joachim |
| description | Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral and undergo enantiomeric enrichment in mammalian species, which may modulate PCB developmental neurotoxicity. This study measures levels and enantiomeric enrichment of PCB 95 and its hydroxylated metabolites (OH-PCBs) in adult female C57Bl/6 mice following subchronic exposure to racemic PCB 95. Tissue levels of PCB 95 and OH-PCBs increased with increasing dose. Dose-dependent enantiomeric enrichment of PCB 95 was observed in brain and other tissues. OH-PCBs also displayed enantiomeric enrichment in blood and liver, but were not detected in adipose and brain. In light of data suggesting enantioselective effects of chiral PCBs on molecular targets linked to PCB developmental neurotoxicity, our observations highlight the importance of accounting for PCB and OH-PCB enantiomeric enrichment in the assessment of PCB developmental neurotoxicity. |
| doi_str_mv | 10.1021/es302810t |
| format | Article |
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M. E ; Lein, Pamela J ; Veng-Pedersen, Peter ; Lehmler, Hans-Joachim</creator><creatorcontrib>Kania-Korwel, Izabela ; Barnhart, Christopher D ; Stamou, Marianna ; Truong, Kim M ; El-Komy, Mohammed H. M. E ; Lein, Pamela J ; Veng-Pedersen, Peter ; Lehmler, Hans-Joachim</creatorcontrib><description>Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral and undergo enantiomeric enrichment in mammalian species, which may modulate PCB developmental neurotoxicity. This study measures levels and enantiomeric enrichment of PCB 95 and its hydroxylated metabolites (OH-PCBs) in adult female C57Bl/6 mice following subchronic exposure to racemic PCB 95. Tissue levels of PCB 95 and OH-PCBs increased with increasing dose. Dose-dependent enantiomeric enrichment of PCB 95 was observed in brain and other tissues. OH-PCBs also displayed enantiomeric enrichment in blood and liver, but were not detected in adipose and brain. In light of data suggesting enantioselective effects of chiral PCBs on molecular targets linked to PCB developmental neurotoxicity, our observations highlight the importance of accounting for PCB and OH-PCB enantiomeric enrichment in the assessment of PCB developmental neurotoxicity.</description><identifier>ISSN: 0013-936X</identifier><identifier>EISSN: 1520-5851</identifier><identifier>DOI: 10.1021/es302810t</identifier><identifier>PMID: 22974126</identifier><identifier>CODEN: ESTHAG</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Chemical compounds ; Environmental Pollutants - metabolism ; Environmental Pollutants - toxicity ; Environmental science ; Female ; Hydroxylation ; Medical sciences ; Metabolites ; Mice ; Mice, Inbred C57BL ; Neurotoxicity ; PCB ; Polychlorinated biphenyls ; Polychlorinated Biphenyls - metabolism ; Polychlorinated Biphenyls - toxicity ; Rodents ; Stereoisomerism ; Toxicology ; Various organic compounds</subject><ispartof>Environmental science & technology, 2012-10, Vol.46 (20), p.11393-11401</ispartof><rights>Copyright © 2012 American Chemical Society</rights><rights>2014 INIST-CNRS</rights><rights>Copyright American Chemical Society Oct 16, 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a463t-bf7944864d418a82f8049ad8338e52f0d8f00b8d499516fdc61198c0a66bb03b3</citedby><cites>FETCH-LOGICAL-a463t-bf7944864d418a82f8049ad8338e52f0d8f00b8d499516fdc61198c0a66bb03b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/es302810t$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/es302810t$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,780,784,885,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26493377$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22974126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kania-Korwel, Izabela</creatorcontrib><creatorcontrib>Barnhart, Christopher D</creatorcontrib><creatorcontrib>Stamou, Marianna</creatorcontrib><creatorcontrib>Truong, Kim M</creatorcontrib><creatorcontrib>El-Komy, Mohammed H. M. E</creatorcontrib><creatorcontrib>Lein, Pamela J</creatorcontrib><creatorcontrib>Veng-Pedersen, Peter</creatorcontrib><creatorcontrib>Lehmler, Hans-Joachim</creatorcontrib><title>2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and Its Hydroxylated Metabolites Are Enantiomerically Enriched in Female Mice</title><title>Environmental science & technology</title><addtitle>Environ. Sci. Technol</addtitle><description>Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral and undergo enantiomeric enrichment in mammalian species, which may modulate PCB developmental neurotoxicity. This study measures levels and enantiomeric enrichment of PCB 95 and its hydroxylated metabolites (OH-PCBs) in adult female C57Bl/6 mice following subchronic exposure to racemic PCB 95. Tissue levels of PCB 95 and OH-PCBs increased with increasing dose. Dose-dependent enantiomeric enrichment of PCB 95 was observed in brain and other tissues. OH-PCBs also displayed enantiomeric enrichment in blood and liver, but were not detected in adipose and brain. In light of data suggesting enantioselective effects of chiral PCBs on molecular targets linked to PCB developmental neurotoxicity, our observations highlight the importance of accounting for PCB and OH-PCB enantiomeric enrichment in the assessment of PCB developmental neurotoxicity.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chemical compounds</subject><subject>Environmental Pollutants - metabolism</subject><subject>Environmental Pollutants - toxicity</subject><subject>Environmental science</subject><subject>Female</subject><subject>Hydroxylation</subject><subject>Medical sciences</subject><subject>Metabolites</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neurotoxicity</subject><subject>PCB</subject><subject>Polychlorinated biphenyls</subject><subject>Polychlorinated Biphenyls - metabolism</subject><subject>Polychlorinated Biphenyls - toxicity</subject><subject>Rodents</subject><subject>Stereoisomerism</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><issn>0013-936X</issn><issn>1520-5851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkdFqFDEUhoModq1e-AISEKGFHc1JMpnkRmiX1hZa7IWCdyEzybgps5NtkhXHK5_JR_JJTOm6rXh1Dicf__lPfoReAnkLhMI7lxihEkh-hGZQU1LVsobHaEYIsEox8WUPPUvpmhBCGZFP0R6lquFAxQz9oHP6--evOZvXt0VUV27MplsOIYbWr5dunAZ8cLU4xqo-xGa0-DwnfDbZGL5Pg8nO4kuXTRsGn13CR9Hhk9GM2YeVi74zwzCVQemWhfQjPnUrMzh86Tv3HD3pzZDci23dR59PTz4tzqqLjx_OF0cXleGC5artG8W5FNxykEbSXhKujJWMSVfTnljZE9JKy5WqQfS2EwBKdsQI0baEtWwfvb_TXW_albNdOTCaQa-jX5k46WC8_vdl9Ev9NXzTjDc1SFUEXm8FYrjZuJT1ddjEsXjWAEA5gKx5oQ7vqC6GlKLrdxuA6NuY9C6mwr56aGlH_s2lAG-2gEnlE_toxs6ne05wxVjT3HOmSw9c_bfwD1zBpwA</recordid><startdate>20121016</startdate><enddate>20121016</enddate><creator>Kania-Korwel, Izabela</creator><creator>Barnhart, Christopher D</creator><creator>Stamou, Marianna</creator><creator>Truong, Kim M</creator><creator>El-Komy, Mohammed H. 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Toxic occupational diseases</topic><topic>Chemical compounds</topic><topic>Environmental Pollutants - metabolism</topic><topic>Environmental Pollutants - toxicity</topic><topic>Environmental science</topic><topic>Female</topic><topic>Hydroxylation</topic><topic>Medical sciences</topic><topic>Metabolites</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Neurotoxicity</topic><topic>PCB</topic><topic>Polychlorinated biphenyls</topic><topic>Polychlorinated Biphenyls - metabolism</topic><topic>Polychlorinated Biphenyls - toxicity</topic><topic>Rodents</topic><topic>Stereoisomerism</topic><topic>Toxicology</topic><topic>Various organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kania-Korwel, Izabela</creatorcontrib><creatorcontrib>Barnhart, Christopher D</creatorcontrib><creatorcontrib>Stamou, Marianna</creatorcontrib><creatorcontrib>Truong, Kim M</creatorcontrib><creatorcontrib>El-Komy, Mohammed H. M. 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M. E</au><au>Lein, Pamela J</au><au>Veng-Pedersen, Peter</au><au>Lehmler, Hans-Joachim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and Its Hydroxylated Metabolites Are Enantiomerically Enriched in Female Mice</atitle><jtitle>Environmental science & technology</jtitle><addtitle>Environ. Sci. Technol</addtitle><date>2012-10-16</date><risdate>2012</risdate><volume>46</volume><issue>20</issue><spage>11393</spage><epage>11401</epage><pages>11393-11401</pages><issn>0013-936X</issn><eissn>1520-5851</eissn><coden>ESTHAG</coden><abstract>Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral and undergo enantiomeric enrichment in mammalian species, which may modulate PCB developmental neurotoxicity. 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| ispartof | Environmental science & technology, 2012-10, Vol.46 (20), p.11393-11401 |
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| subjects | Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Chemical compounds Environmental Pollutants - metabolism Environmental Pollutants - toxicity Environmental science Female Hydroxylation Medical sciences Metabolites Mice Mice, Inbred C57BL Neurotoxicity PCB Polychlorinated biphenyls Polychlorinated Biphenyls - metabolism Polychlorinated Biphenyls - toxicity Rodents Stereoisomerism Toxicology Various organic compounds |
| title | 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and Its Hydroxylated Metabolites Are Enantiomerically Enriched in Female Mice |
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