White Matter Integrity in Highly Traumatized Adults With and Without Post-Traumatic Stress Disorder
Prior structural imaging studies of post-traumatic stress disorder (PTSD) have observed smaller volumes of the hippocampus and cingulate cortex, yet little is known about the integrity of white matter connections between these structures in PTSD samples. The few published studies using diffusion ten...
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| Veröffentlicht in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 2012-11, Vol.37 (12), p.2740-2746 |
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| creator | FANI, Negar KING, Tricia Z JOVANOVIC, Tanja GLOVER, Ebony M BRADLEY, Bekh CHOI, Kisueng ELY, Timothy GUTMAN, David A RESSLER, Kerry J |
| description | Prior structural imaging studies of post-traumatic stress disorder (PTSD) have observed smaller volumes of the hippocampus and cingulate cortex, yet little is known about the integrity of white matter connections between these structures in PTSD samples. The few published studies using diffusion tensor imaging (DTI) to measure white matter integrity in PTSD have described individuals with focal trauma rather than chronically stressed individuals, which limits generalization of findings to this population; in addition, these studies have lacked traumatized comparison groups without PTSD. The present DTI study examined microstructural integrity of white matter tracts in a sample of highly traumatized African-American women with (n=25) and without (n=26) PTSD using a tract-based spatial statistical approach, with threshold-free cluster enhancement. Our findings indicated that, relative to comparably traumatized controls, decreased integrity (measured by fractional anisotropy) of the posterior cingulum was observed in participants with PTSD (p |
| doi_str_mv | 10.1038/npp.2012.146 |
| format | Article |
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The few published studies using diffusion tensor imaging (DTI) to measure white matter integrity in PTSD have described individuals with focal trauma rather than chronically stressed individuals, which limits generalization of findings to this population; in addition, these studies have lacked traumatized comparison groups without PTSD. The present DTI study examined microstructural integrity of white matter tracts in a sample of highly traumatized African-American women with (n=25) and without (n=26) PTSD using a tract-based spatial statistical approach, with threshold-free cluster enhancement. Our findings indicated that, relative to comparably traumatized controls, decreased integrity (measured by fractional anisotropy) of the posterior cingulum was observed in participants with PTSD (p<0.05). These findings indicate that reduced microarchitectural integrity of the cingulum, a white matter fiber that connects the entorhinal and cingulate cortices, appears to be associated with PTSD symptomatology. The role of this pathway in problems that characterize PTSD, such as inadequate extinction of learned fear, as well as attention and explicit memory functions, are discussed.</description><identifier>ISSN: 0893-133X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1038/npp.2012.146</identifier><identifier>PMID: 22871912</identifier><identifier>CODEN: NEROEW</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Adult ; Adult and adolescent clinical studies ; Anisotropy ; Anxiety disorders. 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The few published studies using diffusion tensor imaging (DTI) to measure white matter integrity in PTSD have described individuals with focal trauma rather than chronically stressed individuals, which limits generalization of findings to this population; in addition, these studies have lacked traumatized comparison groups without PTSD. The present DTI study examined microstructural integrity of white matter tracts in a sample of highly traumatized African-American women with (n=25) and without (n=26) PTSD using a tract-based spatial statistical approach, with threshold-free cluster enhancement. Our findings indicated that, relative to comparably traumatized controls, decreased integrity (measured by fractional anisotropy) of the posterior cingulum was observed in participants with PTSD (p<0.05). These findings indicate that reduced microarchitectural integrity of the cingulum, a white matter fiber that connects the entorhinal and cingulate cortices, appears to be associated with PTSD symptomatology. The role of this pathway in problems that characterize PTSD, such as inadequate extinction of learned fear, as well as attention and explicit memory functions, are discussed.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>22871912</pmid><doi>10.1038/npp.2012.146</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Anisotropy Anxiety disorders. Neuroses Behavioral sciences Biological and medical sciences Black or African American Brain - pathology Brain research Cluster Analysis Depression - pathology Depression - psychology Diffusion Tensor Imaging Female Gyrus Cinguli - pathology Hippocampus - pathology Humans Image Processing, Computer-Assisted Indexing in process Male Medical sciences Middle Aged Models, Statistical Original Post traumatic stress disorder Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rape - psychology Risk Factors Stress Disorders, Post-Traumatic - pathology Stress Disorders, Post-Traumatic - psychology Surveys and Questionnaires Trauma Veterans Violence - psychology Wounds and Injuries - pathology Wounds and Injuries - psychology Young Adult |
| title | White Matter Integrity in Highly Traumatized Adults With and Without Post-Traumatic Stress Disorder |
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