Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat

Key points Peripheral chemoreflex sensitivity is enhanced in hypertension yet the role of these receptors in the development and maintenance of high blood pressure remains unknown. Carotid chemoreceptors were denervated in both young and adult spontaneously hypertensive rats (SHRs) by sectioning the...

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Veröffentlicht in:	The Journal of physiology 2012-09, Vol.590 (17), p.4269-4277
Hauptverfasser:	Abdala, Ana P., McBryde, Fiona D., Marina, Nephtali, Hendy, Emma B., Engelman, Zoar J., Fudim, Marat, Sobotka, Paul A., Gourine, Alexander V., Paton, Julian F. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Animals Arterial Pressure - physiology Baroreceptors Baroreflex - physiology Blood pressure Cardiovascular Cardiovascular system Carotid body Carotid Body - physiopathology Carotid sinus Chemoreception Chemoreception (internal) Chemoreceptor Cells - physiology Chemoreceptors (internal) Denervation Disease Models, Animal Glomus cells Heart Rate - physiology Humans Hypersensitivity Hypertension Hypertension - etiology Hypertension - physiopathology Hypertension - therapy Hypoxia Nerves Prehypertension - etiology Prehypertension - physiopathology Prehypertension - therapy Rats Rats, Inbred SHR Rats, Wistar Reflexes Rodents sodium cyanide Sympathetic nervous system Treatment Outcome
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