Prevalence and pharmacological modulation of humoral immunity to AAV vectors in gene transfer to synovial tissue

Antibodies against adeno-associated viral (AAV) vectors are highly prevalent in humans. Both preclinical and clinical studies showed that antibodies against AAV block transduction even at low titers, particularly when the vector is introduced into the bloodstream. Here we measured the neutralizing a...

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Veröffentlicht in:	Gene therapy 2013-04, Vol.20 (4), p.417-424
Hauptverfasser:	Mingozzi, F, Chen, Y, Edmonson, S C, Zhou, S, Thurlings, R M, Tak, P P, High, K A, Vervoordeldonk, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/51/201 631/1647/2300/1514 631/250/2152/2153 692/699/1670/498 Adeno-associated virus Antibodies, Monoclonal, Murine-Derived - therapeutic use Antibodies, Neutralizing - immunology Arthritis, Rheumatoid - therapy B-Lymphocytes - immunology Biomedical and Life Sciences Biomedicine Care and treatment Cell Biology Dependovirus - genetics Dependovirus - immunology Dependoviruses DNA virus infections Drug therapy Gene Expression Gene Therapy Genetic aspects Genetic Therapy Genetic transformation Genetic Vectors - blood Genetic Vectors - genetics Genetic Vectors - immunology Health aspects Human Genetics Humans Immune system Immunity, Humoral Immunotherapy Monoclonal antibodies Nanotechnology Original original-article Pharmacogenetics Physiological aspects Prevalence studies (Epidemiology) Rheumatoid arthritis Rituximab Synovial Fluid - immunology Transduction, Genetic Viruses
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