Effects of sorafenib on C-terminally truncated androgen receptor variants in human prostate cancer cells

Recent evidence suggests that the development of castration resistant prostate cancer (CRPCa) is commonly associated with an aberrant, ligand-independent activation of the androgen receptor (AR). A putative mechanism allowing prostate cancer (PCa) cells to grow under low levels of androgens, is the...

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Veröffentlicht in:	International journal of molecular sciences 2012-09, Vol.13 (9), p.11530-11542
Hauptverfasser:	Zengerling, Friedemann, Streicher, Wolfgang, Schrader, Andres J, Schrader, Mark, Nitzsche, Bianca, Cronauer, Marcus V, Höpfner, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Androgens - metabolism Antigens Antineoplastic Agents - pharmacology Binding Sites - genetics Cancer therapies Cell Line, Tumor Cell Proliferation - drug effects Electronic mail systems Gene amplification Gene Expression Regulation, Neoplastic Humans Ligands Male Mutation Niacinamide - analogs & derivatives Niacinamide - pharmacology Phenylurea Compounds - pharmacology Phosphorylation Prostate cancer Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - genetics Proteasome Endopeptidase Complex - metabolism Protein Binding Protein Isoforms - genetics Protein Isoforms - metabolism Protein Kinase Inhibitors - pharmacology Proteins Receptors, Androgen - genetics Receptors, Androgen - metabolism Signal Transduction - drug effects
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